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The authors show that the Hippo pathway transcriptional coactivators Yap1 (show YAP1 Proteins) and Wwtr1 are specifically localized to the presumptive epidermis and notochord, and play a critical and unexpected role in posterior body extension by regulating Fibronectin (show FN1 Proteins) assembly underneath the presumptive epidermis and surrounding the notochord.
Altogether, the data suggest that Wwtr1 establishes the compact wall architecture necessary for trabeculation, and that Nrg/Erbb2 (show ERBB2 Proteins) signaling negatively regulates its nuclear localization and therefore its activity.
Yap (show YAP1 Proteins)/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Taz (show TAZ Proteins) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.
Taz (show TAZ Proteins)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles
When transcriptional coactivators Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
TAZ (show TAZ Proteins) has a critical role in osteoblast differentiation in vivo
MRTF is essential for TAZ (show TAZ Proteins) expression; TAZ (show TAZ Proteins) and MRTF inhibit each other's cytosolic mobility and stimulus-induced nuclear accumulation; they antagonize each other's stimulatory effect on the alpha-smooth muscle actin (show ACTG2 Proteins) promoter, which harbours nearby cis (show CISH Proteins)-elements for both, but synergize on isolated TEAD-elements.
YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) mechanotransduction integrates with cell-cell communication pathways for fine-grained orchestration of stem cell decisions.
The TAZ WW domain exhibits a binding preference for the second of the two PPxY motifs of LATS1 in vitro. We modelled the structure of the domain in complex with LATS1 PPxY2 peptide and, through molecular dynamics simulations, show that WW domain-PPxY2 complex is stable with some flexibility in the peptide region.
In the present review, we focus on the functions of YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) in cancer, discuss their potential as new therapeutic target for tumor treatment, and provide valuable suggestions for further study in this field.
functional evaluation of a HTM cell monolayer using a permeability assay demonstrated that the inhibition of YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) attenuated the DEX-induced impairment of permeability. These findings suggest that YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) play pivotal roles in the DEX-induced cytoskeletal changes of HTM cells, and reveal novel potential mechanisms for the development and progression of glaucoma
WWTR1 promotes cell proliferation and inhibits apoptosis of GC cells by regulating cell cycle/apoptosisassociated factors, and effectors in the TGFbeta (show TGFB1 Proteins) pathway.
EphA2 (show EPHA2 Proteins)-mediates glutaminolysis through YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activation in HER2 (show ERBB2 Proteins)-positive breast cancer and may serve as potential therapeutic targets in patients.
Depletion of either YES-associated protein (YAP (show YAP1 Proteins)) or transcriptional coactivator with PDZ-motif (TAZ (show TAZ Proteins)) sensitised cancer cell lines to MLN8237, resulting in apoptosis and reduction in aurora-A (show AURKA Proteins).
High TAZ (show TAZ Proteins) expression is associated with breast cancer.
Nuclear localization of YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) was reduced in DMOG-treated primary tubular epithelial cells.
SnoN (show SKIL Proteins) interacts with multiple components of the Hippo pathway to inhibit the binding of Lats2 to TAZ (show TAZ Proteins) and the subsequent phosphorylation of TAZ (show TAZ Proteins), leading to TAZ (show TAZ Proteins) stabilization.
MOB1 (show HOPX Proteins)-dependent YAP1 (show YAP1 Proteins)/TAZ (show TAZ Proteins)-TEAD complex functions as a transcriptional repressor of SOX9 (show SOX9 Proteins) and thereby negatively regulates chondrogenesis.
TAZ (show TAZ Proteins) regulates cell fate depends on not only the cell type but also its subcellular localization.
The results suggested that TAZ (show TAZ Proteins) may suppress apoptosis and premature senescence in spermatogenic cells by inhibiting the p53 (show TP53 Proteins)-p21 signaling pathway, thus playing important roles in the maintenance and control of reproductive function.
The role of Yap (show YAP1 Proteins) and Wwtr1 in the Hippo signaling pathway and the regulation of spermatogenesis in mice are reported.
Taz (show TAZ Proteins) and Yap (show YAP1 Proteins) have overlapping functions in promoting myoblast proliferation but Taz (show TAZ Proteins) then switches to enhance myogenic differentiation.
A crucial role for YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) in the maintenance of the postnatal adrenal cortex.
TAZ (show TAZ Proteins) is a critical factor for SRC kinase (show CSK Proteins)-mediated intestinal tumor formation and regeneration.
YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) plays multifaceted roles for endothelial cell behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation
Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.
This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.
WW domain containing transcription regulator 1
, WW domain-containing transcription regulator protein 1
, WW domain-containing transcription regulator protein 1-like
, transcriptional co-activator with PDZ-binding motif
, transcriptional coactivator with PDZ-binding motif
, transcriptional coactivator with PDZ binding motif
, transcriptional co-activator with PDZ-binding motif (TA)Z
, transcriptional co-activator with PDZ-binding motif (TAZ)