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Yap (show YAP1 Proteins)/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Taz (show TAZ Proteins) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.
Taz (show TAZ Proteins)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles
When transcriptional coactivators Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
TAZ (show TAZ Proteins) has a critical role in osteoblast differentiation in vivo
Rottlerin exerted its tumor suppressive function via inactivation of TAZ (show TAZ Proteins) in non-small cell lung carcinoma cells.
These results indicate that TAZ (show TAZ Proteins) is an independent prognostic factor and plays an important role in Non-Small Cell lung cancer (NSCLC)progression and may serve as a novel therapeutic target of NSCLC.
TAZ (show TAZ Proteins) is overexpressed in glioma and translocated more into nucleus in high grade glioma. TAZ (show TAZ Proteins) is involved in gliomagenesis by promoting glioma growth and may benefit to epithelial mesenchymal transformation.
TAZ (show TAZ Proteins) may be implicated in the proliferation and migration of hDPSCs.
YAP (show YAP1 Proteins)/ TAZ (show TAZ Proteins) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (show CCNE1 Proteins) and CREB (show CREB1 Proteins)
FZD7 may promote glioma cell proliferation via upregulation of TAZ (show TAZ Proteins).
this study indicates that TAZ (show TAZ Proteins) proteins are linked to prognosis and therefore could be therapeutic targets in conventional osteosarcomas
These results demonstrate a critical role of the activation of YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) by disturbed flow in promoting atheroprone phenotypes and atherosclerotic lesion development.
These findings uncover a suppressive role of SYNPO2 in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP/TAZ, and suggest that SYNPO2 might provide a potential prognosis marker and novel therapeutic strategy.
Study showed that TAZ (show TAZ Proteins) and YAP (show YAP1 Proteins) are commonly activated oncoproteins in sarcomas.
A crucial role for YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) in the maintenance of the postnatal adrenal cortex.
TAZ (show TAZ Proteins) is a critical factor for SRC kinase (show CSK Proteins)-mediated intestinal tumor formation and regeneration.
YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) plays multifaceted roles for endothelial cell behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation
Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.
This study identifies YAP/TAZ as central mediators of VEGF signaling
TAZ is required for TGFbeta induction of smooth muscle genes and is also required for the differentiated VSMC phenotype; synergy between TAZ and SRF, and TAZ and Myocardin (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells.
Results demonstrate a pivotal role for TAZ (show TAZ Proteins) in regulating the differentiation of Treg cells and TH17 cells.
ABL (show ABL1 Proteins) potentiated the assembly and activation of the RUNX2 (show RUNX2 Proteins)-TAZ (show TAZ Proteins) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (show PPARG Proteins)-mediated adipogenesis.
the transcription regulators YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) localise to the nucleus in the basal layer of skin and are elevated upon wound healing.
These results suggest that vinculin (show VCL Proteins) promotes the nuclear localization of transcription factor TAZ (show TAZ Proteins) to inhibit the adipocyte differentiation on rigid extracellular matrix.
This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.
WW domain containing transcription regulator 1
, WW domain-containing transcription regulator protein 1
, WW domain-containing transcription regulator protein 1-like
, transcriptional co-activator with PDZ-binding motif
, transcriptional coactivator with PDZ-binding motif
, transcriptional coactivator with PDZ binding motif
, transcriptional co-activator with PDZ-binding motif (TA)Z
, transcriptional co-activator with PDZ-binding motif (TAZ)