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BNIP-2 is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO domain with membrane phosphatidylserine.
BNIP-2 directly interacted with the motor and tail domains of KIF5B via its BCH domain.
Data imply that SIRT1 may mediate MPP(+)-induced cytotoxicity, possibly through the regulation of BNIP2.
Inhibition of BNIP-2 expression did not affect the susceptibility to NK cell-mediated killing.
Transfection of the bnip2 cDNA in neuroblastoma cell line results in massive cell death counteracted by Bcl-2 overexpression; bnip2 is the mediator of the anti-apoptotic activity of estrogens in a variety of cells
BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.
BNIP-2 has a role in regulating cell dynamics with a novel Rho GTPase-activating protein, BPGAP1
BNIP-2 in vivo induces cell dynamics by recruiting Cdc42
Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities.
These findings suggest that mBNIP-21 functions without need of the Bcl-2 homology 3 domain but its Cdc42GAP homology domain is critical for its activity in inducing cell elongation, membrane protrusions and apoptotic cell death.
Nip21 gene expression reduces coxsackievirus B3 replication by promoting apoptosis (Nip21)
Cdo also interacts with Bnip-2, a protein that binds the small guanosine triphosphatase (GTPase) Cdc42 and a negative regulator of Cdc42, Cdc42 GTPase-activating protein (GAP).
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector.
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
, BCL2/adenovirus E1B 19kD interacting protein 2
, BCL2/adenovirus E1B 19 kDa-interacting protein 2 beta
, BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP2
, BCL2/adenovirus E1B interacting protein 1, NIP2
, Bcl-2 and E1B 19 kDa interacting protein