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anti-Mouse (Murine) BOC Antibodies:
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Human Polyclonal BOC Primary Antibody for ELISA, WB - ABIN314264
Okada, Charron, Morin, Shin, Wong, Fabre, Tessier-Lavigne, McConnell: Boc is a receptor for sonic hedgehog in the guidance of commissural axons. in Nature 2006
BOC is expressed at high levels in adult articular chondrocytes, with a tissue-restricted pattern compared to 11 other adult tissues.
Findings provide evidence for a dual requirement for Boc and Gas1 during early development of the palate, mediating cell cycle regulation during growth and subsequent fusion of the palatal shelves.
BOC interacts with ABL and activates JNK thereby promoting neuronal differentiation and neurite outgrowth.
Overweight in mice and enhanced adipogenesis in vitro are associated with lack of the hedgehog coreceptor boc
Elevated Boc levels induce proliferation of granule cell precursors in early medulloblastoma.
The results of this study proposed that expression of Boc in cells from the ventrotemporal crescent of the retina is required to sustain Zic2 expression, likely by regulating the levels of Shh signaling from the nearby cRGCs. Zic2.
Cdo;Boc double mutants on a largely Cdo-resistant genetic background have lobar holoprosencephaly.
Genetic loss-of-function of GAS1, Cdon and BOC in SHH is associated with defective cell proliferation.
Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner
Expression of the boc gene during murine embryogenesis
Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity.
data suggest that Boc is essential as a receptor for Shh in commissural axon guidance
Boc expression increases in subcutaneous white adipose tissue and decreases in intra-abdominal epididymal white adipocytes in obese mice.
we report the identification of missense BOC variants in HPE patients. Consistent with these alleles functioning as HPE modifiers, individual variant BOC proteins had either loss- or gain-of-function properties in cell-based SHH signaling assays.
Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype
Boc receptor is required for segregation of ipsilateral axons at the optic chiasm and, conversely, Boc expression in contralateral retinal ganglion cells prevents their axons from crossing the optic chiasm.
CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage
BOC, along with CDO, defines a new subfamily of the immunoglobulin superfamily that is conserved from Drosophila to man. BOC and CDO form a putative receptor complex that stimulates differentiation of myoblasts.
The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation.
, brother of CDO
, Boc homolog (mouse)
, brother of CDO-like
, biregional Cdon binding protein
, brother of CDON
, cell adhesion associated, oncogene regulated 2
, biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein