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Human Polyclonal HDAC7 Primary Antibody for ELISA - ABIN543296
Meinke, Liberator: Histone deacetylase: a target for antiproliferative and antiprotozoal agents. in Current medicinal chemistry 2001
Show all 3 Pubmed References
Human Polyclonal HDAC7 Primary Antibody for IP, IHC - ABIN223302
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
Human Polyclonal HDAC7 Primary Antibody for ICC, IF - ABIN4316779
Murata, Yoshimoto, Hatae, Akagi, Mizoguchi, Hata, Kuga, Nakamizo, Amano, Sayama, Iihara: Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression. in Journal of neuro-oncology 2015
Human Monoclonal HDAC7 Primary Antibody for RNAi, ELISA - ABIN565634
Malik, Jiang, Garee, Verdin, Lee, OMalley, Zhang, Belaguli, Oesterreich: Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. in Molecular and cellular biology 2009
High HDAC7 expression is associated with recurrence and metastasis in colorectal cancer.
Study suggests that Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation via deacetylating Stat3. Also, high HDAC7 mRNA level was found to be correlated with poor prognosis of human lung cancer patients.
High HDAC7 expression is associated with distant metastasis in gastric cancer.
silencing induces apoptosis and autophagy in salivary mucoepidermoid carcinoma cells
Nur77 suppresses CD4(+) T cell proliferation and uncover a suppressive role for Irf4 in TH2 polarization; halving Irf4 gene-dosage leads to increases in GATA3(+) and IL-4(+) cells.
Study found increased HDAC7 expression in human pancreatic islets from type 2 diabetic compared with non-diabetic donors. HDAC7 expression correlated negatively with insulin secretion in human islets.
silencing HDAC7 can reset the tumor suppressor activity of STAT3, independently of the EGFR/PTEN/TP53 background of the glioblastoma.
This study demonstrated a simple and straightforward method of quantifying proneural/mesenchymal markers in glioblastoma. Of note, HDAC7 expression might be a novel therapeutic target in glioblastoma treatment.
identify a new target of ROCK signaling via myosin phosphatase subunit (MYPT1) and histone deacetylase (HDAC7) at the nuclear level
Study identifies the miR-34a-HDAC1/HDAC7-HSP70 K246 axis as a novel molecular signature predictive of therapy resistance.
The transcriptional function of HCS was shown by in vitro pull down and in vivo co-immunoprecipitation assays to depend on its interaction with the histone deacetylases HDAC1, HDAC2 and HDAC7
endothelial progenitor cells involved in the angiogenesis might be controlled by VEGF-PKD1-HDAC7 axis, which regulates the EPCs angiogenesis by PKD1, but not the ERK and PI3K pathway
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.
Expression of JHDM2A was significantly increased but HDAC2, HDAC7, and SUV39H2 were significantly down-regulated in Systemic Sclerosis B cells relative to controls
Authors identified acetyltransferase p300 and deacetylase HDAC7 as enzymes modulating human T cell leukemia virus type 1 Tax protein acetylation.
Our findings uncover a novel role for HDAC7 in maintaining the identity of a particular cell type by silencing lineage-inappropriate genes.
VEGF and PKC promote degradation-independent protein ubiquitination of FLNB to control intracellular trafficking of HDAC7.
demonstrated for the first time that AKAP12 tumor/angiogenesis suppressor gene is an epigenetic target of HDAC7
HDAC7 reduction in COPD causes a defect of HIF-1alpha induction response to hypoxia with impaired VEGF gene expression. This poor cellular adaptation might play a role in the pathogenesis of COPD.
The expression of HDAC7 protein plays an important role in the apoptosis and vascular tubulogenesis of hepatocellular carcinoma by the upregulation of p21 and HIF-1alpha and the downregulation of cyclin E and MMP10.
HDAC7 is a bona fide transcriptional repressor essential for B cell development.
In the dorsal hippocampus, HDAC7 expression is decreased following contextual fear conditioning.
This study demonstrated that hdac7 decrease in skeletal muscle in muscle atrophy.
HDAC7 in osteoclasts is an important molecular regulator of MITF activity and bone homeostasis.
Hdac7 degradation enhances beta-catenin transcriptional activity in growth plate chondrocytes.
In hepatic stellate cells, CYLD removed HDAC7 from the hepatocyte growth factor promoter and induced HGF expression.
HDAC7 overexpression suppresses, whereas HDAC7 deletion enhances, osteoclastogenesis
Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance
Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear beta-catenin translocation.
Data suggest that HDAC7 nuclear export governs a self-sustaining autoexcitatory loop.
Data indicate that CTLs had high expression of the histone deacetylase HDAC7 but continually phosphorylated and exported this transcriptional repressor from the nucleus.
HDAC7 is a neuroprotective protein acting by a mechanism that is independent of its deacetylase activity but involving the inhibition of c-jun expression.
Sp1 plays an important role in the regulation of Hdac7 gene expression in SMC differentiation from ES cells
Results provide novel insight into the mechanisms that regulate myocyte differentiation and migration by controlling the subcellular distribution of HDAC7 in differentiating myoblasts.
Hdac7 maintains vascular integrity by repressing MMP-10.
These results strongly suggest that CRM1 mediated-nuclear export of HDAC7 is independent of HDAC7 phosphorylation and its association with 14-3-3s.
Myosin phosphatase dephosphorylates HDAC7 and promotes its nuclear localization, leading to the repression of the HDAC7 target, Nur77, and the inhibition of apoptosis in CD4+CD8+ thymocytes.
The expression of distinct HDAC7 mutants or the abrogation of HDAC7 expression can either enhance or inhibit the signal-dependent differentiation of a CD4(+)/CD8(+) cell line.
HDAC7 undergoes alternative splicing during ES cell differentiation. HDAC7 splicing is important for SMC differentiation and vessel formation in embryonic development
AtHDA7 is crucial for female gametophyte development and embryogenesis in Arabidopsis.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, histone deacetylase 7A
, histone deacetylase 7