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Human HOPX Protein expressed in Escherichia coli (E. coli) - ABIN1686718
Flom, Behal, Rosen, Cole, Johnson: Definition of the minimal fragments of Sti1 required for dimerization, interaction with Hsp70 and Hsp90 and in vivo functions. in The Biochemical journal 2007
Show all 5 Pubmed References
HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis
The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90 (show HSP90 Proteins)) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop (show STIP1 Proteins)) is a useful prototype to study the fundamental molecular details about the Hop (show STIP1 Proteins)-Hsp90 (show HSP90 Proteins) interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol (show DUOXA1 Proteins).
HOPX is functionally regulated by SCL (show KRT7 Proteins) in hematoendothelial differentiation of mesoderm progenitor cells.
HOPX is a distinctive homeobox (show Lbx1 Proteins) gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML (show RUNX1 Proteins) patients.
HOPX has a role in the pathogenesis of skin cancers and skin diseases.
these data indicate that the disruption of the PrP(C (show PRNP Proteins))-HOP (show STIP1 Proteins) complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC (show CALR Proteins)).
HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer.
Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis.
The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene.
Data show that binding of heat shock proteins Hsp70 (show HSP70 Proteins) and Hsp90 (show HSP90 Proteins) requires prior binding of Hop (show STIP1 Proteins) protein to Hsp90 (show HSP90 Proteins).
Analysis of the hematopoietic stem/progenitor cell pool in Hopx-/- mice demonstrated significantly reduced cell frequencies and impaired engraftment in competitive repopulation assays, thus providing functional validation of this positional candidate gene
Type I alveolar cells expressing Hopx manifest plasticity to regenerate type II alveolar cells in the lung.
Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 (show IL2 Proteins) Expression.
Hopx integrates Bmp and Wnt (show WNT2 Proteins) signaling by physically interacting with activated Smads and repressing Wnt (show WNT2 Proteins) genes.
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure.
Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas (show FAS Proteins)-induced apoptosis.
Hopx is required for the function of regulatory T cells induced by DCs and the promotion of DC-mediated T cell unresponsiveness in vivo.
Hdac2 (show HDAC2 Proteins), Hopx, and Gata4 (show GATA4 Proteins) coordinately regulate cardiac myocyte proliferation during embryonic development.
data show that Hop (show STIP1 Proteins) can inhibit serum response factor-dependent transcriptional activation by recruiting histone deacetylase (HDAC (show HDAC1 Proteins)) activity and can form a complex that includes HDAC2 (show HDAC2 Proteins)
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene.
, lung cancer-associated Y protein
, not expressed in choriocarcinoma clone 1
, not expressed in choriocarcinoma protein 1
, odd homeobox 1 protein
, odd homeobox protein 1
, homeobox only domain
, homeobox-only protein
, homeodomain only protein
, odd homeobox 1
, global ischemia induced protein GIIG15B
, global ischemia-induced gene 15B protein
, global ischemia-induced protein 15B
, HOP homeobox