Browse our anti-s100b (S100B) Antibodies

Human S100 Calcium Binding Protein B (S100B) interaction partners

1. In patients treated with ipilimumab and nivolumab, baseline S100B and increasing S100B levels of >145% as well as baseline LDH were associated with impaired overall survival (OS) whereas increasing LDH of >25% was not (P = .64). S100B could serve as a strong baseline marker for OS in melanoma patients receiving anti-PD-1 therapy

2. Results suggest that the prognostic biomarker S-100beta protein has a low clinical value to identify patients at risk of persistent post-concussion symptoms

3. This study demonstrated that the T allele at the rs9722 locus of the S100B gene was a significant risk factor for severe Hand, Foot, and Mouth Disease.

4. Study shows that longitudinally, there were no significant associations between changes in brain imaging parameters and S100beta after false discovery rate correction. These data provide some weak evidence that S100beta may be an informative biomarker of brain white matter aging.

5. serum levels elevated in diabetic ketoacidosis

6. This study investigated a fragment of the disordered p53 C-terminal domain (CTDf) that interacts with one of its partner molecules, S100B, as a representative Intrinsically disordered regions (IDRs).

7. S100B was an independent prognostic factor

8. Study reports of an association between S100B mRNA and mercury exposure in humans. Study reports a significant correlation between mercury content in hair and S100B mRNA levels in blood.

9. CSF-S100B might be a potential candidate biomarker for neuromyelitis optica spectrum disorder in discriminating, evaluating severity, and predicting disability.

10. S100B may be involved in the FGFR1-mediated inflammatory response during OA, which may be considered as a potential therapeutic target.

11. Elevated serum level of S100B in patients with multiple traumas combined delirium prior to ICU discharge is closely associated with poor clinical prognosis

12. strong association between serum S100B and peripheral neuropathy in neuropsychiatric systemic lupus erythematous

13. rs9722, a functional SNP in the 3'-UTR of the S100B gene, was strongly associated with age of onset of Parkinson's disease.

14. The S100B gene rs9722 polymorphism may contribute to the susceptibility of IS.

15. It is unclear if the higher S100B concentration in football players playing at least 50 plays was caused by exercise or impacts. Therefore, if serum S100B is to be used as a biomarker of impacts, and possible brain injury in sport, exercise time and intensity should be taken into account as confounding variables.

16. High S100B expression is associated with chemoresistance in ovarian cancer.

17. The serum levels of S100B in Groups A and B rose after the injury and reached a peak on the 4th day of injury. Serum levels of NSE and S100B protein can reflect the degree of spinal cord injury.

18. Serum levels of S100B (and neuron-specific enolase) at admission were related to initial Glasgow Coma Scale (GSC) scores, and these levels one week after traumatic brain injury were related to six month GSC scores.

19. Studied use of serum S100B as a biomarker to predict injury in patients with mild head injury. Found patients with cranial injury detected by CT, had higher S100B protein levels than those without cranial injury.

20. The expression of serum S100beta in patients with postoperative cognitive dysfunction was significantly increased

Mouse (Murine) S100 Calcium Binding Protein B (S100B) interaction partners

1. levels of S100B differentially affect skeletal muscle repair upon acute injury and in the context of muscular dystrophy, and S100B might be regarded as a potential molecular target in Duchenne muscular dystrophy .

2. Our findings demonstrate that S100B promotes microglia M1 polarization to aggravate cerebral ischemia, and provide a better understanding on the therapeutic effects of S100B and/or its antagonist/neutralization antibody in stroke.

3. S100B may be a promising target for pharmacological interventions aimed at repressing diabetes.

4. Data (including data from studies in knockout mice) suggest that S100b acting as a humoral factor impairs glycolysis in muscle (myoblasts, myotubes, and skeletal muscles) independent of insulin action; this effect appears to be due to inhibition of Gapdh activity from enhanced poly(ADP-ribosyl)ation of Gapdh. (S100B = S100 protein, beta polypeptide, neural; Gapdh = glyceraldehyde-3-phosphate dehydrogenase)

5. S100B inhibits C3H/10T1/2 murine embryonic mesenchyma.l cells into osteoblasts. S100B stimulates C3H/10T1/2 cell differentiation into adipocytes.

6. The results of this study showed that S100B affects behavioral despair in female mice through functional interaction with the 5-HT7 receptor.

7. Data show that S100B has direct effects on macrophages, enhancing particularly CCL22 and IL-1beta expression and modulates the inflammatory response in uveoretinitis and this is likely to be, at least in part, via a direct effect on macrophages.

8. Data show that high glucose increased protein-protein interaction between Steap4 and S100B in mesangial (MES13) cells.

9. high glucoseinduced profibrotic genes (TGFbeta, type IV collagen and fibronectin) and cell hypertrophyrelated p21WAF1 are dependent on S100B.

10. S100A1 and S100B are dispensable for endochondral ossification during skeletal development.

11. Data suggest up-regulation of S100b/RAGE (advanced glycosylation end-product receptor) signaling plays role in inflammatory interaction between adipocytes/macrophages; adipocyte secretion of S100b is up-regulated by Tnf (tumor necrosis factor-alpha).

12. Gioma production of S100B enhancestumor growth through CCL2 upregulation and tumor-associated macrophages chemoattraction.

13. HMGB1, S100B, and RAGE signaling modulate the hippocampal inflammatory response and might play key roles in surgery-induced cognitive decline.

14. S100B is a proinflammatory cytokine bridging RAGE and CD166/ALCAM downstream effector mechanisms, both being compensatory upregulated after genetic deletion of its counterpart.

15. S100B expression may serve to modulate cardiac metabolism and adverse consequences of AGE in diabetic post-MI remodeling and function

16. S100B is expressed in mouse photoreceptor cone outer segments but not in rods.

17. The RAGE pathway may play an important role in STAT3 induction in glioma-associated macrophages and microglia, a process that may be mediated through S100B.

18. S100B and APP levels are simultaneously increased within Down syndrome neural progenitors, their secretions are synergistically enhanced in a paracrine fashion, and their overexpressions disrupt mitochondrial membrane potentials and redox states.

19. Unlike in the hippocampus-dependent tasks, S100B-KO mice were indistinguishable from wild-type mice in both cerebellum-dependent motor coordination and delay eyeblink conditioning.

20. Data support S100B inhibition as a novel strategy for reducing cortical plaque load, gliosis and neuronal dysfunction in Alzheimer disease (AD) and suggest that both extracellular as well as intracellular S100B contribute to AD histopathology.

Cow (Bovine) S100 Calcium Binding Protein B (S100B) interaction partners

1. As CSF-S100B levels in calves with neurologic diseases widely differed, the utility of CSF-S100B as a diagnostic marker for neurologic diseases in cattle remains inconclusive.

2. S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE-dependent regulation of several inflammation-related events including activation and migration of microglia

3. X-ray crystallography was used here to characterize an interaction between Ca(2)(+)-S100B and TRTK-12, a target that binds to the p53-binding site on S100B.

4. Intracellular S100B might modulate myoblast differentiation by interfering with MyoD expression in an NF-kappaB-dependent manner.

5. S100b activates guanylate cyclase in a calcium-dependent manner [review]

6. Structural studies in combination with biochemical data are used to develop a model for calcium-induced activation of human nuclear serine/threonine kinase (NDR) kinase by S100B.

7. S100B shows a sufficient thermostability to resist pasteurization but not spry-drying in milk formulas for preterm and term infants.

8. Structures of pentamidine (Pnt) bound to Ca(2+)-loaded and Zn(2+),Ca(2+)-loaded S100B were determined by X-ray crystallography at 2.15 A (R(free)=0.266) and 1.85 A (R(free)=0.243) resolution, respectively.

Rabbit S100 Calcium Binding Protein B (S100B) interaction partners

1. S100B protein can regulate the inflammatory response of SF and may affect the repair of cartilage damage in osteoarthritis, and the mechanism may be related to the activation of FGF-2/FGFR1 signaling pathway.

2. The time course of S100B serum values following spinal cord decompression correlates with outcome; the initial degree of paresis is not a prognostic factor to predict outcome.

Zebrafish S100 Calcium Binding Protein B (S100B) interaction partners

1. This study demonstrated that One singular glomerulus (mdG2) exhibits S100 and parvalbumin-positive fibers, apparently originating from all crypt cells plus some microvillous olfactory sensory neuronss.