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Full name:: SIX Homeobox 4 Proteins (SIX4)

On www.antibodies-online.com are 4 SIX Homeobox 4 (SIX4) Proteins from 3 different suppliers available. Additionally we are shipping SIX4 Antibodies (29) and and many more products for this protein. A total of 36 SIX4 products are currently listed.

Synonyms:: AI047561, AREC3, TrexBF

list all proteins	Gene Name	GeneID	UniProt
	SIX4	20474	Q61321
	SIX4	51804	Q9UIU6
Rat SIX4	SIX4	299138
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Mouse (Murine) SIX Homeobox 4 (SIX4) interaction partners

significant co-localization of binding sites for MyoD (show MYOD1 Proteins) and Six proteins on over a thousand mouse genomic DNA regions, were found.
The results indicated that low Six4 and Six5 gene dosage improved dystrophic phenotypes of Dmd(mdx (show DMD Proteins)) /Y mice by enhancing muscle regeneration, and suggested that SIX4 and SIX5 are potentially useful de novo targets in therapeutic applications against muscle disorders, including DMD (show DMD Proteins).
results reveal a role for Six4 during adult muscle regeneration and suggest a widespread mechanism of cooperation between Six4 and MyoD (show MYOD1 Proteins).
the transcription factors Six1 (show SIX1 Proteins) and Six4 are required for male gonadal differentiation.
Direct molecular regulation of the myogenic determination gene Myf5 (show MYF5 Proteins) by Pax3 (show PAX3 Proteins), with modulation by Six1 (show SIX1 Proteins)/4 factors, is exemplified by the -111 kb-Myf5 (show MYF5 Proteins) enhancer
Data show that absence of Six1 (show SIX1 Proteins) and Six4 leads to the development of dorsal myofibers lacking expression of fast-type muscle genes, and mainly expressing a slow-type muscle program.
These results suggest that Six1 (show SIX1 Proteins) and Six4 genes are expressed in the taste bud cells, in newly formed or surviving type-II cells.
Six4 and Six5 repressed, while Six1 (show SIX1 Proteins) activated myogenin (show MYOG Proteins) expression, suggesting that the differential regulation of myogenin (show MYOG Proteins) expression is responsible for the differential effects of Six genes
Six1 (show SIX1 Proteins) and Six4 expression is required to specifically activate fast-type muscle genes
Data show that Six4 is transcriptional regulatory element X (TrexBF) in skeletal myocytes and transactivates the muscle creatine kinase (show CKM Proteins) enhancer.

Human SIX Homeobox 4 (SIX4) interaction partners

SIX4 and SIX6 (show SIX6 Proteins) were linked to the lymph node metastasis in NSCLC.

SIX4 Protein Profile

Protein Summary

This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells.

Alternative names and synonyms associated with SIX4

sine oculis-related homeobox 4 (Six4)
SIX homeobox 4 (SIX4)
SIX homeobox 4 (Six4)

AI047561 protein
AREC3 protein
TrexBF protein

Protein level used designations for SIX Homeobox 4 Proteins (SIX4)

homeobox protein SIX4 , sine oculis homeobox homolog 4 , sine oculis-related homeobox 4 homolog , skeletal muscle-specific ARE-binding protein AREC3

GENE ID	SPECIES
20474	Mus musculus
51804	Homo sapiens
490720	Canis lupus familiaris
299138	Rattus norvegicus

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