Browse our anti-SOX8 (SOX8) Antibodies

Human SRY (Sex Determining Region Y)-Box 8 (SOX8) interaction partners

1. Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8.

2. SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells.

3. SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin (show CTNNB1 Antibodies) levels in hepatocellular carcinoma

4. The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis.

5. Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut (show GUSB Antibodies).

6. SOX2 (show SOX2 Antibodies) and SOX17 (show SOX17 Antibodies) expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 8 (SOX8) interaction partners

1. Both Sox8 and Sox10 (show SOX10 Antibodies) are jointly required for myelin maintenance and myelin gene expression.

2. In this study characterized novel neuronal expression of the SoxE (show SOX10 Antibodies) factor, Sox8, specifically within striatal projection neurons of the embryonic and postnatal mouse striatum.

3. Concluding, this study shows that, in addition to its crucial role in testis development, Sox9 (show SOX9 Antibodies), together with Sox8 and coordinately with Dmrt1 (show DMRT1 Antibodies), also controls adult testis maintenance.

4. Binding of mrhl RNA to the Sox8 promoter is accompanied by the assembly of other regulatory factors involving Myc (show MYC Antibodies)-Max-Mad transcription factors, corepressor Sin3a (show SIN3A Antibodies), and coactivator Pcaf (show KAT2B Antibodies)

5. These results suggest that Sox8 is essential in Sertoli cells for germ cell differentiation, partly by controlling the microenvironment of the seminiferous epithelium.

6. combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 (show SOX9 Antibodies) target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors

7. Sox9 (show SOX9 Antibodies) and Sox8 maintain integrity of the basal lamina to prevent testis cord disintegration and both factors actively suppress the ovarian program during early testis development.

8. Seven regions near the Sox8 gene as potential enhancers, were identified.

9. SOX8 has a role in testis differentiation in mice and synergizes with SF1 (show SF1 Antibodies) to activate the Amh (show AMH Antibodies) promoter in vitro

10. Sox8 acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins