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anti-Human SPAG9 Antibodies:
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these data suggest that the TFEB (show TFEB Antibodies)/TMEM55B (show TMEM55B Antibodies)/JIP4 pathway coordinates lysosome movement in response to a variety of stress conditions.
AKAP4 (show AKAP4 Antibodies) and SPAG9 genes may find use as diagnostic biomarkers for CRC (show CALR Antibodies).
Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer
SPAG9 mRNA and protein overexpression in lung cancer tissue, and the presence of SPAG9 IgG antibody in peripheral blood of lung cancer patients indicates that it has potential as a biomarker for lung cancer diagnosis.
SPAG9-elevated expression contributes to malignant behavior and poor prognosis of breast cancer and may support a potential indicator in treatment selection.
Study suggest that suppression of miR (show MLXIP Antibodies)-141 may cause an aberrant overexpression of SPAG9 promoting growth and metastasis of hepatocellular carcinoma cells.
expression of SPAG9 in ECC cells with TGF-beta1 (show TGFB1 Antibodies) treatment and spheroids formation was increased
PLK1 binding to JIP4 was found in G2 phase and mitosis, and PLK1 binding was self-primed by PLK1 phosphorylation of JIP4.
Based on in vitro assays, we found miR (show MLXIP Antibodies)-200a-3p significantly inhibit cancer cell proliferation by inducing apoptosis.
FOXK1 protein levels and activity are regulated by associating with JLP and PLK1
JLP-deficiency impaired T-cell proliferation.
data establish JSAP1 (show MAPK8IP3 Antibodies) and JLP as positive regulators of kinesin-1-dependent axonal transport, which prevents neuronal degeneration.
JSAP1 (show MAPK8IP3 Antibodies) and JLP play critical roles in kinesin-1-dependent axonal transport
JSAP1 (show MAPK8IP3 Antibodies) and JLP, which might be paralogous to each other, are critical and functionally redundant in cytokinesis and control ARF6 (show ARF6 Antibodies) localization to the midbody by forming a tripartite complex of JSAP1 (show MAPK8IP3 Antibodies)/JLP, active ARF6 (show ARF6 Antibodies), and kinesin-1.
JLP in skin basal keratinocytes plays an important role in UVB-induced apoptosis by modulating p38 MAPK (show MAPK14 Antibodies) signaling pathways.
Data indicate a role of a scaffolding protein JLP in the regulation of surface CD40 (show CD40 Antibodies) expression and fine-tuning of dendritic cell (DC) function.
A functional role for JLP in the gep (show GRN Antibodies) oncogene (show RAB1A Antibodies)-regulated neoplastic signaling pathway.
describe a protein, JLP, which acts as a scaffolding protein to bring mitogen-activated protein kinases and their target transcription factors together for the execution of specific signaling pathways
The JIP4 scaffold protein (show HOMER1 Antibodies) therefore appears to be a new component of the p38 MAP kinase (show MAPK14 Antibodies) signaling pathway
analysis of a novel protein-protein interaction between KLC1 and JLP that involves leucine zipper-like domains
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.
C-Jun-amino-terminal kinase-interacting protein 4
, JNK interacting protein
, JNK/SAPK-associated protein
, Max-binding protein
, c-Jun NH2-terminal kinase-associated leucine zipper protein
, cancer/testis antigen 89
, human lung cancer oncogene 6 protein
, lung cancer oncogene 4
, mitogen-activated protein kinase 8-interacting protein 4
, proliferation-inducing gene 6
, protein highly expressed in testis
, sperm surface protein
, sunday driver 1
, JNK-associated leucine-zipper protein
, JNK-interacting leucine zipper
, JNK-interacting protein 4
, JNK/SAPK-associated protein 2
, sperm-associated antigen 9
, sperm associated antigen 9
, C-Jun-amino-terminal kinase-interacting protein 4-like
, c-Jun-amino-terminal kinase-interacting protein 4-like