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these data suggest that the TFEB/TMEM55B/JIP4 pathway coordinates lysosome movement in response to a variety of stress conditions.
AKAP4 and SPAG9 genes may find use as diagnostic biomarkers for CRC.
Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer
SPAG9 mRNA and protein overexpression in lung cancer tissue, and the presence of SPAG9 IgG antibody in peripheral blood of lung cancer patients indicates that it has potential as a biomarker for lung cancer diagnosis.
SPAG9-elevated expression contributes to malignant behavior and poor prognosis of breast cancer and may support a potential indicator in treatment selection.
Study suggest that suppression of miR-141 may cause an aberrant overexpression of SPAG9 promoting growth and metastasis of hepatocellular carcinoma cells.
expression of SPAG9 in ECC cells with TGF-beta1 treatment and spheroids formation was increased
PLK1 binding to JIP4 was found in G2 phase and mitosis, and PLK1 binding was self-primed by PLK1 phosphorylation of JIP4.
Based on in vitro assays, we found miR-200a-3p significantly inhibit cancer cell proliferation by inducing apoptosis.
FOXK1 protein levels and activity are regulated by associating with JLP and PLK1
SPAG9 overexpression in gastric cancer correlates with poor prognosis and contributes to gastric cancer cell proliferation
SPAG9 was upregulated in nonmelanoma skin cancer when compared with normal skin.
SPAG9 expression is significantly increased in prostate cancer and it may be involved in the process of prostate cancer cell motility, migration and angiogenesis.
knockdown of Sec8 enhances the binding of JIP4 to MAPK kinase 4, thereby decreasing the phosphorylation of MAPK kinase 4, JNK, and p38.
SPAG9 upregulates PODXL expression in human astrocytoma cells at the PODXL gene promoter/transcriptional level through a JNKdependent mechanism.
SPAG9 is overexpressed in human HCC and serves as a prognostic marker. SPAG9 contributes to cancer cell growth through regulation of cyclin proteins.
SPAG9 is overexpressed in human prostate cancers and contributes to prostate cancer cell growth, possibly through cyclin protein regulation.
down regulation of SPAG9 reduces growth and invasive potential of triple-negative breast cancer cells, suggesting that SPAG9 may be a potential target for therapeutic use.
data in clinical specimens indicated that SPAG9 is potential biomarker and therapeutic target for bladder TCC.
High SPAG9 expression is associated with endometrial cancer.
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants.
C-Jun-amino-terminal kinase-interacting protein 4
, JNK interacting protein
, JNK/SAPK-associated protein
, Max-binding protein
, c-Jun NH2-terminal kinase-associated leucine zipper protein
, cancer/testis antigen 89
, human lung cancer oncogene 6 protein
, lung cancer oncogene 4
, mitogen-activated protein kinase 8-interacting protein 4
, proliferation-inducing gene 6
, protein highly expressed in testis
, sperm surface protein
, sunday driver 1
, JNK-associated leucine-zipper protein
, JNK-interacting leucine zipper
, JNK-interacting protein 4
, JNK/SAPK-associated protein 2
, sperm-associated antigen 9
, sperm associated antigen 9
, C-Jun-amino-terminal kinase-interacting protein 4-like
, c-Jun-amino-terminal kinase-interacting protein 4-like