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Human YBX1 Protein expressed in Wheat germ - ABIN1325506
Dhawan, Liu, Pytlak, Kulshrestha, Blaxall, Taubman: Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells. in Molecular and cellular biology 2012
structural basis of the interactions between YB-1 and mRNAs carrying the aforementioned motifs
YB-1 silencing sensitized SH-SY5Y cells to cisplatin and promoted the apoptosis induced by cisplatin due to down-regulation of multidrug resistance (MDR) 1 protein via NF-kappaB (show NFKB1 Proteins) signaling pathway.
YB-1 promoted lung adenocarcinoma growth and progression in vitro and in vivo through directly binding to the MACC1 promoter and enhancing MACC1/c-Met pathway.
Data indicate that YB-1 translocates to the nucleus coordinately with p53 (show TP53 Proteins) expression and is involved in gemcitabine resistance in bladder cancer suggesting that nuclear expression of YB-1 is important for resistance to chemotherapy including gemcitabine in TP53 (show TP53 Proteins)-mutated bladder cancer.
Results show that YBX1 expression is regulated by TP53TG1 which binds to YBX1 promoter and prevents its nuclear localization.
Kindlin-2 (show FERMT2 Proteins) is up-regulated in glioma cells and acts as an oncogene (show RAB1A Proteins). It is an independent risk factor for poor prognosis. The Kindlin-2 (show FERMT2 Proteins)/YB-1/beta-catenin (show CTNNB1 Proteins) complex promotes EGFR (show EGFR Proteins) transcription and contributes to glioma progression. Kindlin-2 (show FERMT2 Proteins) is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 (show FERMT2 Proteins) may be a novel strategy for glioma treatment.
Results showed that YB-1 promoted hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell proliferation, migration and colony formation. Also, YB-1 was found to increased drug resistance in HCC (show FAM126A Proteins). These findings suggested that YB-1 was a key factor in HCC (show FAM126A Proteins) tumorigenesis and maintained the HCC (show FAM126A Proteins) initiating cell population.
Furthermore, use of both indirubin 3'-oxime and actinomycin D in combination increased the anticancer effect on HepG2 cells. Indirubin 3'-oxime is a novel and efficient inhibitor of anticancer agent-induced YB-1 nuclear translocation.
It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C (show CORO1C Proteins). The association between YB-1 and coronin-1C (show CORO1C Proteins) offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated.
Inhibition of YBX1 suppressed lung cancer growth partly via the CDC25a pathway and high expression of YBX1/CDC25a predicts poor prognosis in human lung adenocarcinoma.
The amounts of YB-1 and YB-1 mRNA in rabbit organs and several cell lines.
results prove direct inhibitory action of YB-1 on its mRNA translation, while the positive effect of PABP (show PABPC1 Proteins) is realized through displacing YB-1 from the regulatory element
his is the first report showing the increased expression of YB-1 during muscle regeneration after ischemic injury.
YB-1 orchestrates onset and resolution of renal inflammation via IL-10 (show IL10 Proteins) gene regulation.
Monocytic YB-1 has prominent and distinct roles for cellular feed-forward crosstalk and resolution of inflammatory processes by its ability to regulate cell differentiation and cytokine/chemokine (show CCL1 Proteins) synthesis.
YB-1 is induced by Shh (show SHH Proteins) in CGNPs
this study shows that innate immunity activation by muramyl peptides is mediated via an interaction between YB1 and NOD2
In conclusion, TGF-beta (show TGFB1 Proteins) signaling pathway may influence liver fibrosis by incorporating with YB-1, indicating that YB-1 could be a potential target for therapies against liver fibrosis.
Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs (show NR2E3 Proteins), suggesting their roles in further regulation of the pluripotent state of ESCs (show NR2E3 Proteins).
In the initial stage of myocyte differentiation, transcription of the YB-1 gene was regulated by E2F1 (show E2F1 Proteins) and Sp1 (show SP1 Proteins), and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).
YB-1 is a novel intracellular target of activated protein C (show PROC Proteins) in renal ischemia-reperfusion injury
miR (show MLXIP Proteins)-382 inhibits osteosarcoma metastasis and relapse by targeting YB-1 protein.
transcription factor; acts as a regulator of protein tyrosine phosphatase PTP1B expression
B box-binding protein
, CCAAT-binding transcription factor I subunit A
, DNA-binding protein B
, Y-box transcription factor
, Y-box-binding protein 1
, enhancer factor I subunit A
, major histocompatibility complex, class II, Y box-binding protein I
, nuclease sensitive element binding protein 1
, nuclease-sensitive element-binding protein 1
, CCAAT-binding transcription factor 1 subunit A
, DNA binding protein B
, Y box transcription factor
, enhancer factor 1 alpha
, enhancer factor 1 subunit A
, FRG Y
, frg y1
, frog Y-box proteins
, Y-box binding protein 1