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Human YBX1 Protein expressed in Wheat germ - ABIN1325506
Dhawan, Liu, Pytlak, Kulshrestha, Blaxall, Taubman: Y-box binding protein 1 and RNase UK114 mediate monocyte chemoattractant protein 1 mRNA stability in vascular smooth muscle cells. in Molecular and cellular biology 2012
Kindlin-2 (show FERMT2 Proteins) is up-regulated in glioma cells and acts as an oncogene (show RAB1A Proteins). It is an independent risk factor for poor prognosis. The Kindlin-2 (show FERMT2 Proteins)/YB-1/beta-catenin (show CTNNB1 Proteins) complex promotes EGFR (show EGFR Proteins) transcription and contributes to glioma progression. Kindlin-2 (show FERMT2 Proteins) is a potential diagnostic and prognostic marker in glioma, and inhibition of Kindlin-2 (show FERMT2 Proteins) may be a novel strategy for glioma treatment.
Results showed that YB-1 promoted hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell proliferation, migration and colony formation. Also, YB-1 was found to increased drug resistance in HCC (show FAM126A Proteins). These findings suggested that YB-1 was a key factor in HCC (show FAM126A Proteins) tumorigenesis and maintained the HCC (show FAM126A Proteins) initiating cell population.
Furthermore, use of both indirubin 3'-oxime and actinomycin D in combination increased the anticancer effect on HepG2 cells. Indirubin 3'-oxime is a novel and efficient inhibitor of anticancer agent-induced YB-1 nuclear translocation.
It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C (show CORO1C Proteins). The association between YB-1 and coronin-1C (show CORO1C Proteins) offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated.
Inhibition of YBX1 suppressed lung cancer growth partly via the CDC25a pathway and high expression of YBX1/CDC25a predicts poor prognosis in human lung adenocarcinoma.
The long noncoding RNA CAR intergenic 10 bound and stabilized transcription factor Y-box-binding protein 1 (YB-1), leading to up-regulation of the epidermal growth factor receptor (EGFR (show EGFR Proteins)) and proliferation of lung cancer cells.
Results firstly reported that YB-1 whose mRNA expression is regulated by HPV18 E6 promotes epithelial-mesenchymal transition and progression of cervical cancer via enhancing the expressions of Snail (show SNAI1 Proteins).
YB-1 localization was significantly altered in the nuclei of tumor blasts derived from bone marrow or peripheral blood.
Two interacting partners of urokinase-type plasminogen activator (uPA) receptor (show PLAUR Proteins), the cysteine-rich angiogenic inducer 61 (Cyr61 (show CYR61 Proteins)) and the Y-box-binding protein 1 (YB-1) were identified and their differential expression demonstrated in the triple-negative breast cancer (TNBC) cells as well as in tumors.
No other significant associations between clinical prognostic factors and YB-1/p18 (show CDKN2C Proteins) serum levels were detected.
The amounts of YB-1 and YB-1 mRNA in rabbit organs and several cell lines.
results prove direct inhibitory action of YB-1 on its mRNA translation, while the positive effect of PABP (show PABPC1 Proteins) is realized through displacing YB-1 from the regulatory element
YB-1 is induced by Shh (show SHH Proteins) in CGNPs
this study shows that innate immunity activation by muramyl peptides is mediated via an interaction between YB1 and NOD2
In conclusion, TGF-beta (show TGFB1 Proteins) signaling pathway may influence liver fibrosis by incorporating with YB-1, indicating that YB-1 could be a potential target for therapies against liver fibrosis.
Reduction in the expression of YBX1 and ILF3 controls the expression of pluripotency-related genes in ESCs (show NR2E3 Proteins), suggesting their roles in further regulation of the pluripotent state of ESCs (show NR2E3 Proteins).
In the initial stage of myocyte differentiation, transcription of the YB-1 gene was regulated by E2F1 (show E2F1 Proteins) and Sp1 (show SP1 Proteins), and was then gradually replaced under the control of both MyoD (show MYOD1 Proteins) and myogenin (show MYOG Proteins).
YB-1 is a novel intracellular target of activated protein C (show PROC Proteins) in renal ischemia-reperfusion injury
miR (show MLXIP Proteins)-382 inhibits osteosarcoma metastasis and relapse by targeting YB-1 protein.
YB-1 was revealed in a population of Cajal bodies in 2-cell mouse embryos but not in other cells studied.
The effects of MIA/CD-RAP (show MIA Proteins) on transcriptional regulation in chondrocytes, through the regulation of p54(nrb (show NONO Proteins)) via YBX1 contributes to the understanding of chondrogenesis.
The formation of intracytoplasmic Gag-RNA complexes is facilitated by YB-1, which promotes MMTV virus assembly.
transcription factor; acts as a regulator of protein tyrosine phosphatase PTP1B expression
B box-binding protein
, CCAAT-binding transcription factor I subunit A
, DNA-binding protein B
, Y-box transcription factor
, Y-box-binding protein 1
, enhancer factor I subunit A
, major histocompatibility complex, class II, Y box-binding protein I
, nuclease sensitive element binding protein 1
, nuclease-sensitive element-binding protein 1
, CCAAT-binding transcription factor 1 subunit A
, DNA binding protein B
, Y box transcription factor
, enhancer factor 1 alpha
, enhancer factor 1 subunit A
, FRG Y
, frg y1
, frog Y-box proteins
, Y-box binding protein 1