YBX1 Protein (AA 2-322) (His tag)

Catalog No. ABIN5713952

Product Details

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Protein Type: Recombinant

Protein Characteristics: AA 2-322

Origin: Mouse

Source: Yeast

Purification tag / Conjugate: This YBX1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: SSEAETQQPP AAPAAALSAA DTKPGSTGSG AGSGGPGGLT SAAPAGGDKK VIATKVLGTV KWFNVRNGYG FINRNDTKED VFVHQTAIKK NNPRKYLRSV GDGETVEFDV VEGEKGAEAA NVTGPGGVPV QGSKYAADRN HYRRYPRRRG PPRNYQQNYQ NSESGEKNEG SESAPEGQAQ QRRPYRRRRF PPYYMRRPYA RRPQYSNPPV QGEVMEGADN QGAGEQGRPV RQNMYRGYRP RFRRGPPRQR QPREDGNEED KENQGDETQG QQPPQRRYRR NFNYRRRRPE NPKPQDGKET KAADPPAENS SAPEAEQGGA E

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Alternative Name: YBOX1 (YBX1 Products)

Synonyms: BP-8 Protein, CSDA2 Protein, CSDB Protein, DBPB Protein, MDR-NF1 Protein, NSEP-1 Protein, NSEP1 Protein, YB-1 Protein, YB1 Protein, Byb1 Protein, Cbfa Protein, Dbpb Protein, Ef1a Protein, Msy1 Protein, Nsep1 Protein, Yb1 Protein, bp-8 Protein, csda2 Protein, csdb Protein, dbpb Protein, frgy1 Protein, mdr-nf1 Protein, nsep-1 Protein, nsep1 Protein, yb1 Protein, 1700102N10Rik Protein, C79409 Protein, EF1A Protein, MSY1 Protein, dbpB Protein, mYB-1a Protein, nuclease sensitive element binding protein 1 Protein, Y-box binding protein 1 Protein, Y box binding protein 1 Protein, Y-box binding protein 1 S homeolog Protein, nuclease-sensitive element-binding protein 1 Protein, Y box protein 1 Protein, nsep1 Protein, YBX1 Protein, Ybx1 Protein, ybx1.S Protein, LOC479011 Protein

Background: Mediates pre-mRNA alternative splicing regulation. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds preferentially to 5'-[CU]CUGCG-3' motif in vitro .The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.

Molecular Weight: 37.6 kDa

UniProt: P62960

Pathways: Regulation of Muscle Cell Differentiation