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Human Polyclonal DRD3 Primary Antibody for FACS, IF (p) - ABIN733808
Xu, Wang, Chen, Chen, Li, Shao, Li, Lu, Zhou: Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. in Acta pharmacologica Sinica 2014
DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.
DRD2 (show DRD2 Antibodies) A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 (show OPRM1 Antibodies) A118G and GRIK1 (show GRIK1 Antibodies) rs2832407C>A are not associated with alcoholism alone or in interaction.
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D3R through beta-arrestins. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
this study shows that D3R is palmitoylated more extensively than D2R even though the carboxyl terminus tails of D2R and D3R are highly homologous, and thus provides a new clue regarding the consensus sequence for palmitoylation.
We found statistically significant DNA hypomethylation of the promoter regions of DRD3 (P = 0.032), DRD4 (show DRD4 Antibodies) (P = 0.05), MB-COMT (show COMT Antibodies) (P = 0.009), and AKT1 (show AKT1 Antibodies) (P = 0.0008) associated with increased expression of the corresponding genes in patients with methamphetamine psychosis (P = 0.022, P = 0.034, P = 0.035, P = 0.038, respectively)
Data indicate the effects of sodium ions on the binding affinities of a number of structurally diverse ligands at dopamine D2 and dopamine D3 receptor subtypes, which are important therapeutic targets for the treatment of psychotic disorders.
Study performed docking essays using risperidone and the D3 receptor crystallographic data and results suggested two possible distinct orientations for risperidone at the binding pocket; data highlight important hot spots in the DRD3 binding site bringing relevant information for the development of novel/derivative agents with atypical profile.
Applying an external electric field, at different frequencies, in the logarithmic scale along the z-direction on the dopamine-dopamine receptor D3 complex, at some frequencies has a significant effect on salt bridge interaction and the structural observables, although it does not have any systematic or predictable effect on the dynamical and physical property of the protein.
The results of this study suggest that genotype in DRD3 Ser9Gly was the main factor determining different doses of DAs (show ube3a Antibodies) and PD patients carrying Gly/Gly genotype require higher doses of pramipexole for effective treatment.
Clathrin-mediated internalization of dopamine receptor D3 was responsible for lysosomal degradation.
The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, are expressed throughout limbic circuits, including prefrontal cortex (PFC (show CFP Antibodies)).
this study shows that DRD3 signaling evokes suppressor of cytokine signaling 5 (show SOCS5 Antibodies) expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 (show HAND1 Antibodies) phenotype
this study shows that D3R regulates the effect of methamphetamine on LPS (show TLR4 Antibodies)-induced mast cells activation
This study show the Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP (show ADCYAP1 Antibodies) and receptors and alters their cortical distribution.
Resulting dopamine receptors (D1-to-D3) ratio indicates a strong upregulation of D1R (show DRD1 Antibodies)-mediated pathways in old animals, which is particularly pronounced in the lumbar spinal cord.
Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF (show BDNF Antibodies) in place preference acquisition
Results suggest that the dopamine D3 receptor is centrally involved in the etiology of adult anxiety- and depression-related behaviors that arise from repeated stressful experiences during childhood.
D3R modulates GABAA receptors function in striatum: chronic blockade of D3R increases alpha6 subunit expression and induces insensitivity to the anxiolytic effect of diazepam
The dopamine receptor D1 (show DRD1 Antibodies) but not the D3 is also critical for morphine-induced BDNF (show BDNF Antibodies) expression.
Study identified a unique role for Npas2 (show NPAS2 Antibodies) in the regulation of cocaine reward and dopamine Drd3 receptor expression
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
D(3) dopamine receptor
, dopamine receptor D3
, dopamine receptor 3
, dopamine D3 receptor
, dopaminergic receptor D3
, essential tremor 1
, D3 receptor