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Human Polyclonal DRD3 Primary Antibody for FACS, IF (p) - ABIN733808
Xu, Wang, Chen, Chen, Li, Shao, Li, Lu, Zhou: Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. in Acta pharmacologica Sinica 2014
analysis of molecular dynamics simulations with a cumulative length of ~77 mus of D2R and D3R wild-type and their E2.65A mutants bound to SB269652
This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4 (show DRD4 Antibodies), and FEV (show FEV Antibodies) with aggressive behavior in Chinese adolescents.
SNPs (rs9880168) of the DRD3 were associated with Essential Hypertension in Hani nationality However, none SNPs of DRD1 and DRD3 of best models showed association with Essential Hypertension in Han and Yi nationality.
DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.
DRD2 (show DRD2 Antibodies) A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 (show OPRM1 Antibodies) A118G and GRIK1 (show GRIK1 Antibodies) rs2832407C>A are not associated with alcoholism alone or in interaction.
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D3R through beta-arrestins. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
this study shows that D3R is palmitoylated more extensively than D2R even though the carboxyl terminus tails of D2R and D3R are highly homologous, and thus provides a new clue regarding the consensus sequence for palmitoylation.
We found statistically significant DNA hypomethylation of the promoter regions of DRD3 (P = 0.032), DRD4 (show DRD4 Antibodies) (P = 0.05), MB-COMT (show COMT Antibodies) (P = 0.009), and AKT1 (show AKT1 Antibodies) (P = 0.0008) associated with increased expression of the corresponding genes in patients with methamphetamine psychosis (P = 0.022, P = 0.034, P = 0.035, P = 0.038, respectively)
Data indicate the effects of sodium ions on the binding affinities of a number of structurally diverse ligands at dopamine D2 and dopamine D3 receptor subtypes, which are important therapeutic targets for the treatment of psychotic disorders.
Study performed docking essays using risperidone and the D3 receptor crystallographic data and results suggested two possible distinct orientations for risperidone at the binding pocket; data highlight important hot spots in the DRD3 binding site bringing relevant information for the development of novel/derivative agents with atypical profile.
Heroin-induced impulsive behavior in the 5-choice serial reaction time task is oppositely modulated by D1 and D3 receptor activation.
This study demonstrated that D3 receptor deficiency has sex-specific effects on wheel running activity during training and plateau phases.
The dopamine D3 receptor affects nociceptive behaviors in a sex-specific manner and its absence induces more analgesic behavior in female knock-out mice.
The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, are expressed throughout limbic circuits, including prefrontal cortex (PFC (show CFP Antibodies)).
this study shows that DRD3 signaling evokes suppressor of cytokine signaling 5 (show SOCS5 Antibodies) expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 (show HAND1 Antibodies) phenotype
this study shows that D3R regulates the effect of methamphetamine on LPS (show TLR4 Antibodies)-induced mast cells activation
This study show the Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP (show ADCYAP1 Antibodies) and receptors and alters their cortical distribution.
Resulting dopamine receptors (D1-to-D3) ratio indicates a strong upregulation of D1R (show DRD1 Antibodies)-mediated pathways in old animals, which is particularly pronounced in the lumbar spinal cord.
Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF (show BDNF Antibodies) in place preference acquisition
Results suggest that the dopamine D3 receptor is centrally involved in the etiology of adult anxiety- and depression-related behaviors that arise from repeated stressful experiences during childhood.
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
D(3) dopamine receptor
, dopamine receptor D3
, dopamine receptor 3
, dopamine D3 receptor
, dopaminergic receptor D3
, essential tremor 1
, D3 receptor