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Human Polyclonal DRD3 Primary Antibody for FACS, IF (p) - ABIN733808
Xu, Wang, Chen, Chen, Li, Shao, Li, Lu, Zhou: Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells. in Acta pharmacologica Sinica 2014
The evolution and expression of derd3 were studied.
In amphetamine dependence (AD) group with DRD3 rs6280 C allele carrier, we found IL-2 level was significantly higher than healthy controls, DRD3 rs6280 TT genotype may be associated with favorable recovery in general inflammatory cytokines during period of abstinence. AD patients with DRD3 rs6280 TT genotype revealed a significant down-regulated plasma level of the Th1, Th2, and other cytokines except for IL-6
Study results supported the hypothesis that DRD2 affected risperidone treatment. DRD1 had no significant effect on the response to risperidone, whereas DRD3 might be associated with an improvement in negative symptoms. [systematic review and meta-analysis]
The carriers of DRD3 risk haplotypes is at increased risk of dyskinesia.
The prevalence of polymorphisms of the DRD2 gene and its association with the occurrence of metabolic syndrome in patients with refractory schizophrenia were evaluated
DRD2 Ins/Ins (prevalence ratio (PR)=2.374, 95% confidence interval (CI): 1.105-5.100; P=0.027) and DRD3 Ser/Ser genotypes (PR=1.677, 95% CI 1.077-2.611; P=0.022) were independent and predictors of gastrointestinal symptoms associated with levodopa therapy.
Study represents the first comprehensive investigation of the association between both striatal and extrastriatal D2/D3 receptor binding potential with executive function and verbal learning in medication-naive (5 drug-free) patients with schizophrenia; demonstrates that lower fallypride binding potential in patients with schizophrenia may be associated with better performance.
Its single-nucleotide polymorphisms involves in dopaminergic metabolism and motor and cognitive function in older adults.
This study showed that the DRD3 is a potential genetic factor in the susceptibility to amphetamine dependence and is associated with onset age of drug use through interaction with novelty seeking in a specific patient group in the Han Chinese population.
The C allele of DRD3 rs6280 SNP was associated with increased risk of sleep bruxism (p = 0.02).
Associations between 4 polymorphisms (rs11721264, rs3773678, rs167771, rs324035) and Parkinson's diseasehave been found.
analysis of molecular dynamics simulations with a cumulative length of ~77 mus of D2R and D3R wild-type and their E2.65A mutants bound to SB269652
This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents.
SNPs (rs9880168) of the DRD3 were associated with Essential Hypertension in Hani nationality However, none SNPs of DRD1 and DRD3 of best models showed association with Essential Hypertension in Han and Yi nationality.
Multimodal imaging results suggest that the distribution of D2/3 receptors in the posterior portion of the brain corresponds to the posterior default mode network, as well as to other functional networks to varying degrees.
[(123)I]IBZM SPECT results show that striatal D2/3R availability increases after long-term bariatric-surgery induced weight loss, suggesting that reduced D2/3R availability in obesity is a reversible phenomenon.
Suggest an effect of smoking on ventral striatal D2/3 dopamine receptors that may contribute to nicotine dependence.
Data support the hypothesis of a negative influence of D2/3 receptor blockade on specific cognitive functions in schizophrenia.
DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population.
DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction.
Lowering the level of cellular FLNA caused an elevation in RalA activity and resulted in selective interference with the normal intracellular trafficking and signaling of D3R through beta-arrestins. Knockdown of FLNA or coexpression of active RalA prevented D3R from coupling with G protein.
D3R knockout (D3R(-/-)) mice displayed decreased freezing time of contextual fearing and anxiolytic effects following training sessions consisting of exposure to inescapable electric foot-shocks. Similarly, highly selective blockade of D3Rs by YQA14, a novel D3R antagonist, significantly ameliorated freezing and anxiogenic-like behaviours in the single-prolonged stress model of post-traumatic stress disorder in rats.
Heroin-induced impulsive behavior in the 5-choice serial reaction time task is oppositely modulated by D1 and D3 receptor activation.
This study demonstrated that D3 receptor deficiency has sex-specific effects on wheel running activity during training and plateau phases.
The dopamine D3 receptor affects nociceptive behaviors in a sex-specific manner and its absence induces more analgesic behavior in female knock-out mice.
The D3 dopamine receptor, a member of the Gi-coupled D2 family of dopamine receptors, are expressed throughout limbic circuits, including prefrontal cortex (PFC).
this study shows that DRD3 signaling evokes suppressor of cytokine signaling 5 expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 phenotype
Dopamine Receptor Signaling in MIN6 beta-Cells
this study shows that D3R regulates the effect of methamphetamine on LPS-induced mast cells activation
This study show the Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution.
Resulting dopamine receptors (D1-to-D3) ratio indicates a strong upregulation of D1R-mediated pathways in old animals, which is particularly pronounced in the lumbar spinal cord.
Alcohol enhances the psychostimulant and conditioning effects of mephedrone in adolescent mice; postulation of unique roles of D3 receptors and BDNF in place preference acquisition
Results suggest that the dopamine D3 receptor is centrally involved in the etiology of adult anxiety- and depression-related behaviors that arise from repeated stressful experiences during childhood.
D3R modulates GABAA receptors function in striatum: chronic blockade of D3R increases alpha6 subunit expression and induces insensitivity to the anxiolytic effect of diazepam
The dopamine receptor D1 but not the D3 is also critical for morphine-induced BDNF expression.
Study identified a unique role for Npas2 in the regulation of cocaine reward and dopamine Drd3 receptor expression
Results suggest that D3 receptors and related signaling mechanisms play key roles in reconsolidation of cocaine memories in mice, and that these receptors may serve as novel targets for the treatment of cocaine abuse in humans.
D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production.
Overexpression of D3Rs in the striatum of mice does not elicit cognitive deficits but disrupts motivation, suggesting that changes in D3Rs may be involved in the negative symptoms of schizophrenia.
This study demonstrated that Low dose pramipexole causes D3 receptor-independent reduction of locomotion and responding for a conditioned reinforce/
D3R deficiency results in anxiety-like and depressive-like symptoms that cannot be attributed to motor dysfunction.
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
D(3) dopamine receptor
, dopamine receptor D3
, dopamine receptor 3
, dopamine D3 receptor
, dopaminergic receptor D3
, essential tremor 1
, D3 receptor