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Human Polyclonal ECE1 Primary Antibody for CyTOF, FACS - ABIN4900501
Cottrell, Padilla, Amadesi, Poole, Murphy, Hardt, Roosterman, Steinhoff, Bunnett: Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. in The Journal of biological chemistry 2009
Show all 7 Pubmed References
Human Polyclonal ECE1 Primary Antibody for WB - ABIN5518828
Liu, Zhu, Zhou, Wei, Long, Chen, Ling, Ge, Zhuo: Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells. in Cell stress & chaperones 2014
ECE-1 and ECE-2 levels were significantly reduced in post-mortem brains from dementia with Lewy body patients.
These results indicated that the ECE1 rs212528 and rs213045 polymorphisms had no major role to play in the genetic susceptibility to intracerebral haemorrhage.
results indicate that PKC-phosphorylated ECE-1 is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 production of EC through the regulation of ECE-1 activity.
CK2-increased ECE-1c protein stability is related to augmented migration and invasion of colon cancer cells, shedding light on a novel mechanism by which CK2 may promote malignant progression of this disease.
Thus, our findings suggest that ECE-1 may be a novel hypoxia-inducible factor-target gene.
Structural analysis of membrane-bound hECE-1 dimer using molecular modeling techniques: insights into conformational changes and Abeta1-42 peptide binding.
Nitric oxide inhibits the production of soluble endothelin converting enzyme-1 by endothelial cells.
confirmed that endothelin-converting enzyme 1 (ECE1), EDN1, and EDNRB were involved in SP-induced pigmentation and found that EDN1 secretion was affected by ECE1 and EDN1 siRNAs, but not by EDNRB siRNA
An arterial-specific enhancer of the human endothelin converting enzyme 1 (ECE1) gene is synergistically activated by Sox17, FoxC2, and Etv2
Compared with rs213045 G homozygote, rs213045 TG genotype and rs213045 TT/TG genotypes are in dominant model significantly increased the risk of ischemic stroke.
Although the presence of a soluble form of ECE-1 has been demonstrated in vitro, it is yet to be shown in any human biological fluid. This study, used a combination of mass spectrometry, Western blotting & quenched fluorescent substrate based enzyme assays & showed presence of catalytically active, soluble form of ECE-1 in CSF of subarachnoid hemorrhage subjects.
Data indicate endothelin-converting enzyme-1 (ECE-1) as a target for alternative polyadenylation (APA), a regulatory mechanism aberrantly activated in cancer cells, and the mechanisms leading to ECE-1 overexpression in malignant cells.
the primary function of betaARRs and ECE-1 in SP-dependent inflammatory signaling is to promote resensitization, which allows the sustained NK1R signaling from the plasma membrane that drives inflammation
phosphoramidon and Abeta peptide binding to hECE-1
identify the neural peptidase ECE-1 as a negative regulator of itch on sensory nerves by directly regulating ET-1-induced pruritus
study suggests that the severity of periodontal disease may be associated with the expression of metalloendopeptidase genes, including NEP, ECE1 and ADAM17, in the buccal mucosal epithelium.
C-338A polymorphism of the ECE-1b gene was associated with an increased risk of ischemic stroke in the Chinese Han population.
The altered expression of enzymes regulating the activity of ET-1, NEP and ECE-1, during parturition is controlled by inflammatory cytokines.
Endothelin-converting enzymes degrade intracellular beta-amyloid produced within the endosomal/lysosomal pathway and autophagosomes
The Alzheimer's disease associated intronic haplotype is linked to the 338A variant of known ECE1b promoter variant, 338C>A (rs213045).
It is a amyloid beta degrading enzyme and is expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.
The cardiac expression of prepro-endothelin-1 mRNA, endothelin-converting enzyme-1 mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight
differences in hemodynamic adn ece1 expression between HcB-8 and HcB-23 arteries
Endothelin-converting enzyme-1 gene ablation attenuates pulmonary fibrosis via CGRP-cAMP/EPAC1 pathway.
involved in the physiological degradation of atrial natriuretic peptide
Ece1 is necessary for regression of the cranial arch arteries and growth of the most caudal arch arteries.
Our results provide evidence of structural conservation of mammalian genes encoding ECE-1 and will facilitate a more refined analysis of ECE-1 mRNA expression in the mouse model organism.
increased neuronal PKCepsilon activity can promote Abeta clearance and reduce AD neuropathology through increased endothelin-converting enzyme activity
beta-amyloid levels in the brain are regulated by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme
reduced levels of endothelin converting enzyme-1 mRNA in the male mouse bowel at the time that enteric nervous system precursors migrate into the colon
diabetes and contrast media increased tubular and endothelial cell eCE1, particularly in the medulla
Overexpression of endothelin-converting enzyme reduces Abeta deposits in amyloid precursor protein plus presenilin-1 transgenic mice
These data support a critical role for the ECE-1/ET-1 system in inflammation-associated premature delivery.
ECE-1 increases in different atherosclerosis situations. Up-regulation of ECE-1 could contribute, at least partially, to the development of hypertension seen in apoE-deficient mice.
Ece1 is the gene responsible for Bmd7 and it acts by increasing responsiveness to mechanical loading through modulation of Wnt signaling.
Endosomal endothelin-converting enzyme-1 is a regulator of beta-arrestin-dependent ERK signaling
The ECE1 transcript is constitutively expressed in the 10 tissues tested in Tibetan pig: the liver, subcutaneous fat, kidney, muscle, stomach, heart, brain, spleen, pancreas, and lung.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Regulated during different stages of cycle. Hormonal regulation and intracellular localization of bovine ECE-1 isoforms may provide new insights into endothelin 1 biosynthesis and mode of action in different cellular microenvironments within ovary.
It is suggested that endothelial cells sense shear stress as oxidative stress and transduce signal for the regulation of the gene expression of ECE.
presence of Endothelin-converting enzyme-1 isoforms in different endothelial cell compartments than full-length forms of the enzyme may suggest a distinct physiological role for these proteins
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, endothelin-converting enzyme 1
, endothelin-converting enzyme-1a
, endothelin-converting enzyme-1b
, endothelin-converting enzyme-1d
, Endothelin-converting enzyme 1
, endothelin converting enzyme-1