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Human Polyclonal ECE1 Primary Antibody for CyTOF, FACS - ABIN4900501
Cottrell, Padilla, Amadesi, Poole, Murphy, Hardt, Roosterman, Steinhoff, Bunnett: Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. in The Journal of biological chemistry 2009
Show all 5 Pubmed References
ECE-1 and ECE-2 (show ECE2 Antibodies) levels were significantly reduced in post-mortem brains from dementia with Lewy body patients.
These results indicated that the ECE1 rs212528 and rs213045 polymorphisms had no major role to play in the genetic susceptibility to intracerebral haemorrhage.
results indicate that PKC (show PRRT2 Antibodies)-phosphorylated ECE-1 is a TIMAP (show PPP1R16B Antibodies)-PP1c substrate and this phosphatase complex has an important role in endothelin-1 (show EDN1 Antibodies) production of EC through the regulation of ECE-1 activity.
CK2 (show CSNK2A1 Antibodies)-increased ECE-1c protein stability is related to augmented migration and invasion of colon cancer cells, shedding light on a novel mechanism by which CK2 (show CSNK2A1 Antibodies) may promote malignant progression of this disease.
Thus, our findings suggest that ECE-1 may be a novel hypoxia-inducible factor-target gene.
Nitric oxide inhibits the production of soluble endothelin converting enzyme-1 by endothelial cells.
confirmed that endothelin-converting enzyme 1 (ECE1), EDN1 (show EDN1 Antibodies), and EDNRB (show EDNRB Antibodies) were involved in SP-induced pigmentation and found that EDN1 (show EDN1 Antibodies) secretion was affected by ECE1 and EDN1 (show EDN1 Antibodies) siRNAs, but not by EDNRB (show EDNRB Antibodies) siRNA
An arterial-specific enhancer of the human endothelin converting enzyme 1 (ECE1) gene is synergistically activated by Sox17 (show SOX17 Antibodies), FoxC2 (show FOXC2 Antibodies), and Etv2 (show ETV2 Antibodies)
Although the presence of a soluble form of ECE-1 has been demonstrated in vitro, it is yet to be shown in any human biological fluid. This study, used a combination of mass spectrometry, Western blotting & quenched fluorescent substrate based enzyme assays & showed presence of catalytically active, soluble form of ECE-1 in CSF (show CSF2 Antibodies) of subarachnoid hemorrhage subjects.
Data indicate endothelin-converting enzyme-1 (ECE-1) as a target for alternative polyadenylation (APA (show ENPEP Antibodies)), a regulatory mechanism aberrantly activated in cancer cells, and the mechanisms leading to ECE-1 overexpression in malignant cells.
The cardiac expression of prepro-endothelin-1 (show EDN1 Antibodies) mRNA, endothelin-converting enzyme-1 (show ECEL1 Antibodies) mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight
identify the neural peptidase ECE-1 as a negative regulator of itch on sensory nerves by directly regulating ET-1 (show EDN1 Antibodies)-induced pruritus
differences in hemodynamic adn (show CFD Antibodies) ece1 expression between HcB-8 and HcB-23 arteries
Endothelin-converting enzyme-1 (show ECEL1 Antibodies) gene ablation attenuates pulmonary fibrosis via CGRP (show CALCA Antibodies)-cAMP/EPAC1 (show RAPGEF3 Antibodies) pathway.
involved in the physiological degradation of atrial natriuretic peptide (show NPPA Antibodies)
Ece1 is necessary for regression of the cranial arch arteries and growth of the most caudal arch arteries.
Our results provide evidence of structural conservation of mammalian genes encoding ECE-1 and will facilitate a more refined analysis of ECE-1 mRNA expression in the mouse model organism.
increased neuronal PKCepsilon (show PRKCE Antibodies) activity can promote Abeta (show APP Antibodies) clearance and reduce AD neuropathology through increased endothelin-converting enzyme activity
beta-amyloid levels in the brain are regulated by neprilysin (show MME Antibodies) and endothelin-converting enzyme but not angiotensin-converting enzyme (show ACE Antibodies)
reduced levels of endothelin converting enzyme-1 (show ECEL1 Antibodies) mRNA in the male mouse bowel at the time that enteric nervous system precursors migrate into the colon
The ECE1 transcript is constitutively expressed in the 10 tissues tested in Tibetan pig: the liver, subcutaneous fat, kidney, muscle, stomach, heart, brain, spleen, pancreas, and lung.
study suggests a possible role for endothelin-1 (show EDN1 Antibodies)(resulting from the actions of endothelin-converting enzyme-1) acting via endothelin receptor A (show EDNRA Antibodies) in the control of luteolytic sensitivity in the pig
Differential cell-specific and spatiotemporal expression of the EDN1 (show EDN1 Antibodies) system and NOS (show NOS Antibodies) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Regulated during different stages of cycle. Hormonal regulation and intracellular localization of bovine ECE-1 isoforms may provide new insights into endothelin 1 (show EDN1 Antibodies) biosynthesis and mode of action in different cellular microenvironments within ovary.
It is suggested that endothelial cells sense shear stress as oxidative stress and transduce signal for the regulation of the gene expression of ECE.
presence of Endothelin-converting enzyme-1 isoforms in different endothelial cell compartments than full-length forms of the enzyme may suggest a distinct physiological role for these proteins
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, endothelin-converting enzyme 1
, endothelin-converting enzyme-1a
, endothelin-converting enzyme-1b
, endothelin-converting enzyme-1d
, Endothelin-converting enzyme 1
, endothelin converting enzyme-1