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anti-Human RAX Antibodies:
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Human Polyclonal RAX Primary Antibody for IHC, WB - ABIN350791
Furukawa, Kozak, Cepko: rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 4 Pubmed References
The three consanguineous Egyptian anophthalmia patients carry a novel homozygous c.543+3A>G mutation (IVS2+3A>G) in RAX.
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
Mutations in the newly identified RAX regulatory sequence are not a frequent cause of micro/anophthalmia.
Deletion of Rax in the eye generated loss of central visual pathways and the suprachiasmatic nucleus was absent.
the role of Rax in the early stages of hypothalamic development
Rax and Crx (show CRX Antibodies) cooperatively transactivate Rhodopsin (show RHO Antibodies) and cone opsin (show RHO Antibodies) promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists.
This study provided evidence that Rax is required for the normal differentiation and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cerebrospinal fluid-hypothalamus barrier.
miR (show MLXIP Antibodies)-29b mediated ethanol neurotoxicity through the SP1 (show SP1 Antibodies)/RAX/PKR (show EIF2AK2 Antibodies) cascade.
our study illustrates that Rax is required in ARC (show NOL3 Antibodies)/VMH progenitors to specify neuronal phenotypes within this hypothalamic brain region.
This study demonistrated that the RAX homeoprotein interacts with embryonic enhancer locus for photoreceptor Otx2 (show OTX2 Antibodies) transcription to transactivate Otx2 (show OTX2 Antibodies), mainly in the final cell cycle of retinal progenitors
subpopulations of retinal neurons can be generated in retinal explant cultures from grafted mouse ES cells ectopically expressing the transcription factor Rx/rax
These findings in mice and Drosophila illustrate the importance of RAX for embryonic development.
Development of auxiliary eye structures does not depend on retina-specific gene expression or retinal morphogenesis. Lens formation involves beta-catenin (show CTNNB1 Antibodies) expression in the head surface ectoderm.
We then show that Rx controls proliferation within the MBNB clones independently of Tailless (Tll (show NR2E1 Antibodies)) and Prospero (show PROX1 Antibodies) (Pros), and does not regulate the expression of other key regulators of MB development, Eyeless (Ey) and Dachshund (Dac (show FBXW4 Antibodies)). Our data support that the role of Rx in forebrain development is conserved between vertebrates and fly.
Drx is not required for establishment of the drosophila visual system.
This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.
retina and anterior neural fold homeobox protein
, retinal homeobox protein Rx
, double-stranded RNA-binding protein A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog B
, Rx/rax homeoprotein
, eyeless 1
, retinal homeobox protein Rx1
, retinal homeobox protein Rx2
, retina and anterior neural fold homeobox
, retinal homeobox
, drosophila Rx