RAX antibody (AA 100-313)

Catalog No. ABIN5027505

This Rabbit Polyclonal antibody specifically detects RAX in WB. It exhibits reactivity toward Human.

Quick Overview for RAX antibody (AA 100-313) (ABIN5027505)

Target: RAX (Retina and Anterior Neural Fold Homeobox (RAX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RAX Antibody

Binding Specificity: AA 100-313

Purification: Protein A Chromatography

Immunogen: A partial length recombinant RAX protein (amino acids 100-313) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for RAX

Target: RAX (Retina and Anterior Neural Fold Homeobox (RAX))

Alternative Name: RAX

Background: RAX or PRKRA (retina and anterior neural fold homeobox) is a homeobox-containing transcription factor. It plays an important role in eye development by regulating the initial specification of retinal cells. In the absence of double-stranded RNA, RAX activates EIF2AK2/PKR, so as to phosphorylate EIF2S1/EFI2-alpha leading to inhibition of translation and induction of apoptosis. RAX has been reported to be essential for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia and coloboma. RAX is expressed in blood, bone, brain, spleen and adipose tissues.

Molecular Weight: 30 kDa

Gene ID: 8575

UniProt: O75569

Pathways: Regulatory RNA Pathways