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anti-Human CPS1 Antibodies:
anti-Rat (Rattus) CPS1 Antibodies:
anti-Mouse (Murine) CPS1 Antibodies:
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Human Monoclonal CPS1 Primary Antibody for IHC (p), ELISA - ABIN560455
Lee, Jee, Kwon, Yoon, Xu, Wang, Wang, Thorgeirsson, Lee, Woo, Yoon: Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression. in Hepatology (Baltimore, Md.) 2015
Human Polyclonal CPS1 Primary Antibody for WB - ABIN1539246
Liu, Liu, Yu, Lin, Chu, Deng, Yan, Li, Yao: Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes. in Molecular medicine reports 2017
Dog (Canine) Polyclonal CPS1 Primary Antibody for IHC, IHC (p) - ABIN4300273
van Straten, van Steenbeek, Grinwis, Favier, Kummeling, van Gils, Fieten, Groot Koerkamp, Holstege, Rothuizen, Spee: Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. in PLoS ONE 2014
In silico analysis potentially links CPS1 SNPs with major depression disorder.
Allele and genotype frequencies of the p.Thr1406Asn polymorphism did not differ between the infants with and without NEC, but the minor A-allele was less frequent in the group of 64 infants with the combined outcome NEC or death before 34 weeks of corrected gestational age than in the infants without this outcome. A significant negative association of the A-allele with the combined outcome NEC or death was found.
HNF3beta plays a vital role in regulation of CPS1 gene and could promote the metabolism of ammonia by regulating CPS1 expression.
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
CPS1 knockdown reduced cell growth, decreased levels of metabolites associated with nucleic acid biosynthesis.
These results may offer an increasing understand that CPS1 might have a function in differentiation.
Molecular structure of CPS1 has been deciphered.
CPS1 and CPS1IT1 may be potential prognostic indicators for patients with intrahepatic cholangiocarcinoma.
CPS1 is involved in the urea cycle in weight maintenance.
These results suggest that glycine metabolism and/or the urea cycle represent potentially novel sex-specific mechanisms for the development of atherosclerosis.
Mechanism for Switching On/Off the Urea Cycle
More HCC cells could be identified by the antibody cocktail for CPS1 and P-CK compared with a single antibody.
characterized the only currently known recurrent CPS1 mutation, p.Val1013del found in eleven unrelated patients of Turkish descent; mutation p.V1013del inactivates CPS1 but does not render the enzyme grossly unstable or insoluble
Overexpression of CPS1 is associated with rectal cancers.
study examined patient characteristics, including genetic polymorphism, to identify risk factors associated with development of hyperammonemia during valproic acid-based therapy; found CPS1 4217C>A polymorphism may not be associated with development of hyperammonemia in Japanese population
Findings support the disease-causing role of the mutations reported to affect the CPS1 deficiency, revealing a key role of the small CPS1 domain of unknown function (UFSD) for proper enzyme folding.
CPS1 becomes readily detectable upon hepatocyte apoptotic and necrotic death. Its abundance and short serum half-life suggest that it may be a useful prognostic biomarker in acute liver injury.
Data show that carbamoyl phosphate synthetase 1, an enzyme involved in the urea cycle, 8-oxoguanine DNA glycosylase 1 and DNA polymerase beta, enzymes involved in DNA repair, were expressed at higher levels in Batten disease cells than in normal cells.
the human CPS unknown function domains are spatially located in a region that corresponds to the a/b subunits interface in Escherichia coli CPS. [Review]
Mutation analysis in these patients identified 17 genetic lesions, 9 of which were new confirming their "private" nature.
sequence of cDNA and expression of the enzyme in liver are reported
these data suggest that AhR activation promotes CPS1 recruitment to DNA enhancer sites in the genome, resulting in a specific enzyme-independent post-translational modification of the linker histone H1 protein (H1K34hcit), pivotal in altering local chromatin structure and transcriptional activation.
The results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury.
Taken together with previous findings regarding CPS1 structure and function, homology modeling of mouse CPS1 suggested that nitration at Y1450 in an alpha-helix of allosteric domain prevents activation of CPS1 by its activator, N-acetyl-l-glutamate.
Because ammonia generated during fasting is toxic, SIRT5 protein might play a protective role by converting ammonia to non-toxic urea through deacetylation and activation of CPS1.
Y-box binding protein-1 down-regulates expression of carbamoyl phosphate synthetase-I by suppressing CCAAT enhancer-binding protein-alpha function in mice.
SIRT5 deacetylates CPS1 and upregulates its activity
The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.
carbamoyl-phosphate synthase [ammonia], mitochondrial
, carbamoylphosphate synthetase I
, carbamoyl phosphate synthetase 1
, carbamoyl-phosphate synthetase 1, mitochondrial
, carbamyl phosphate synthetase 1
, CPSase I
, carbamoyl-phosphate synthetase I
, carbamyl phosphate synthetase I
, carboamyl-phosphate synthetase 1
, carbamoyl-phosphate synthase 1, mitochondrial
, carbamoyl-phosphate synthase [ammonia], mitochondrial-like
, carbamoyl-phosphate synthetase III
, peptidase M20 domain-containing protein 1
, probable carboxypeptidase PM20D1
, LOW QUALITY PROTEIN: carbamoyl-phosphate synthase [ammonia], mitochondrial
, carbamoyl-phosphate synthetase 1