Browse our anti-CRY2 (CRY2) Antibodies

Arabidopsis thaliana Cryptochrome 2 (Photolyase-Like) (CRY2) interaction partners

1. Molecular basis for blue light-dependent phosphorylation of Arabidopsis CRY2 has been described.

2. The results demonstrate a CRY-BIC negative-feedback circuitry that regulates the activity of each other.

3. Verticillium dahliae PevD1 indirectly activates Arabidopsis CRY2 by antagonizing NRP (show NRP1 Antibodies) functions. The promotion of CRY2-mediated flowering by a fungal effector outlines a novel pathway by which an external stimulus is recognized and transferred in changing a developmental program.

4. CRY2-CIB1 (show CIB1 Antibodies) and CRY2-CRY2 interactions are governed by well-separated protein interfaces at the two termini of CRY2.

5. Exposure to blue light is required for an in vivo-association of CRY1 (show CRY1 Antibodies) and CRY2 with COP1.

6. Data show that the effect of 3-bromo-7-nitroindazole (3B7N) treatment on gene expression in cryptochromes cry1cry2 is considerably smaller than that in the wild type, indicating that 3B7N specifically interrupts cryptochrome function in the control of seedling development in a light-dependent manner.

7. It describes minimal functional CRY2 and CIB1 (show CIB1 Antibodies) domains maintaining light-dependent interaction and new signaling mutations affecting Arabidopsis thaliana cryptochrome 2 (AtCRY2) photocycle kinetics.

8. this study identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2.

9. the blue light-dependent CRY2 degradation is significantly impaired in the temperature-sensitive cul1 (show CUL1 Antibodies) mutant allele (axr6 (show CUL1 Antibodies)-3), especially under the non-permissive temperature.

10. For growth under a canopy, where blue light is diminished, CRY1 and CRY2 perceive this change and respond by directly contacting two bHLH transcription factors, PIF4 and PIF5.

Human Cryptochrome 2 (Photolyase-Like) (CRY2) interaction partners

1. CRY2 levels (ng/mL) were markedly higher in both Metabolic syndrome (MetS (show ETV3 Antibodies)) groups (non-diabetic and pre-diabetic/diabetic) (all with p-value < 0.001). A reciprocal melatonin-CRY2 relationship was observed in the MetS (show ETV3 Antibodies) (non-diabetic) group (p-value = 0.003).

2. Independent silencing of CRY1 (show CRY1 Antibodies) and CRY2 genes in HAC15 cells resulted in a mild upregulation of HSD3B2 (show HSD3B2 Antibodies) without affecting HSD3B1 (show HSD3B1 Antibodies) expression. In conclusion, our results support the hypothesis that CRY1 (show CRY1 Antibodies) and CRY2, being AngII-regulated genes, and showing a differential expression in APAs when compared with the adjacent adrenal cortex, might be involved in adrenal cell function, and in the regulation of aldosterone production

3. CRY2 may be an anti-oncogene (show RAB1A Antibodies) in osteosarcoma.

4. CRY1 (show CRY1 Antibodies)/2 serve as corepressors for many NRs (show SPNS1 Antibodies).

5. data indicate an oncogenic role of miR (show MLXIP Antibodies)-181d in CRC (show CALR Antibodies) by promoting glycolysis, and miR (show MLXIP Antibodies)-181d/CRY2/FBXL3 (show FBXL3 Antibodies)/c-myc (show MYC Antibodies) feedback loop might be a therapeutic target for patients with CRC (show CALR Antibodies).

6. In the longitudinal analysis, CRY2 SNP rs61884508 was protective from worsening of problematicity of seasonal variations of mood disorder. In the cross-sectional analysis, CRY2 SNP rs72902437 showed evidence of association with problematicity of seasonal variations, as did SNP rs1554338 (in the MAPK8IP1 (show MAPK8IP1 Antibodies) and downstream of CRY2).

7. The earlier reported association of CRY2 variants with dysthymia was confirmed and extended to major depressive disorder.

8. These results demonstrate that CRY2 stability controlled by FBXL3 (show FBXL3 Antibodies) plays a key role in the regulation of human sleep wake behavior.

9. The FOXM1 (show FOXM1 Antibodies) is a negative regulator of CRY2 in breast cancer via enhancing methylation in CRY2 promoter and its high expression is an independent predictor of favorable MR-free survival in ER+ breast cancer patients.

10. CRY2 and FBXL3 (show FBXL3 Antibodies) cooperatively degrade c-MYC (show MYC Antibodies) preventing the development of cancer.

Mouse (Murine) Cryptochrome 2 (Photolyase-Like) (CRY2) interaction partners

1. Circadian clock cryptochrome proteins Cry1 (show CRY1 Antibodies) and Cry2 regulate autoimmunity.

2. CRY1 (show CRY1 Antibodies)/2 seem to repress a distinct subset of PPAR delta (show PPARD Antibodies) target genes in muscle compared to the co-repressor NCOR1 (show NCOR1 Antibodies). In vivo, genetic disruption of Cry1 (show CRY1 Antibodies) and Cry2 enhances sprint exercise performance in mice.

3. CRY2 and FBXL3 (show FBXL3 Antibodies) cooperatively degrade c-MYC (show MYC Antibodies) preventing the development of cancer.

4. In vivo knockdown of Rfk (show RFK Antibodies), Riboflavin (vitamin B2) kinase essential for FAD (show FANCD2 Antibodies) synthesis, altered the expression rhythms of CRY1 (show CRY1 Antibodies), CRY2, and PER1 (show PER1 Antibodies)

5. The present study identified USP7 (show USP7 Antibodies) and TDP-43 (show TARDBP Antibodies) as the regulators of CRY1 (show CRY1 Antibodies) and CRY2, underscoring the significance of the stability control process of CRY proteins for period determination in the mammalian circadian clockwork.

6. Data show that cryptochrome Cry1 (show CRY1 Antibodies) and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP (show AVP Antibodies)) receptor signaling is required to impose circuit-level circadian function.

7. Data suggest that cryptochromes (Cry1 (show CRY1 Antibodies) and Cry2) mediate periodic binding of Ck2b (show CSNK2B Antibodies) (casein kinase 2beta) to Bmal1 (aryl hydrocarbon receptor nuclear translocator-like (show ARNTL Antibodies) protein) and thus inhibit Bmal1 (show ARNTL Antibodies)-Ser90 phosphorylation by Ck2a (show CSNK2A1 Antibodies) (casein kinase 2alpha).

8. Cry2 exerts a critical role in the control of depression-related emotional states and modulates the chronobiological gene expression profile in the mouse amygdala.

9. Cry1/Cry2-deficient mice had significantly lower N6- methyladenosine methylation of RNA and lost the circadian rhythm of N6-methyladenosine levels in RNA.

10. Data show that the intermolecular zinc finger is important for period circadian protein (PER2 (show PER2 Antibodies))-cryptochrome 2 (CRY2) complex formation.