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Polyclonal PDZK1IP1 Primary Antibody for WB - ABIN540344
Kojima, Sher-Chen, Green: Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression. in Genes & development 2012
Show all 2 Pubmed References
Human Polyclonal PDZK1IP1 Primary Antibody for WB - ABIN152919
Silver, Wang, Vogel: Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels. in The Journal of biological chemistry 2003
MAP17 overexpression activates Notch (show NOTCH1 Antibodies) pathway by sequestering NUMB (show NUMB Antibodies). High levels of MAP17 correlated with tumorsphere formation and Notch (show NOTCH1 Antibodies) and Stem gene transcription. Its direct modification causes direct alteration of tumorsphere number and Notch (show NOTCH1 Antibodies) and Stem pathway transcription
We found that the levels of MAP17 were related to clinical features and poor survival in a cohort of 69 patients with different sarcoma types and suggest that MAP17 is a new biomarker to predict the efficacy of bortezomib as a new therapy for sarcomas.
SGLT2 (show SLC5A2 Antibodies)/MAP17 functions as a low-affinity Na(+)-glucose cotransporter (show SLC5A1 Antibodies) in the kidney.
Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 (show EEF1A2 Antibodies) and RPL41 (show RPL41 Antibodies) (ENSG00000279483) genes in the intrahepatic cholangiocarcinoma samples when compared with the matched paratumor samples.
Data show that bortezomib induces a prosurvival response through cytoprotective autophagy and nuclear factor kappa B (NFkappaB (show NFKB1 Antibodies)) nuclear translocation, which is repressed by high levels of membrane-associated protein 17 (MAP17).
In this study we found that the levels of MAP17 were related to clinical findings and survival in a cohort of 58 patients with larynx cancer
Results suggest that the use of MAP17 and SGLT1 (show SLC5A1 Antibodies) markers may identify patients who are likely to exhibit a better response to treatments that boost oxidative stress in other cancer types.
MAP17 is overexpressed in late-stage breast tumors, in which oncogenic activity relies on p38 (show CRK Antibodies) insensitivity to induce intracellular ROS (show ROS1 Antibodies).
The Th cell cytokine-induced up-regulation of MAP17 expression may be linked to the down-regulation of filaggrin (show FLG Antibodies) in normal epidermal keratinocytes, which may be associated with abnormal epidermal differentiation observed in the dermatological diseases.
Large scale genetic screening identifies MAP17 as protein bypassing TNF-alpha (show TNF Antibodies)-induced growth arrest.
membrane associated protein 17 may be an endogenous regulator of cellular PDZ domain containing 1(PDZK1 (show PDZK1 Antibodies)) levels by regulating PDZK1 (show PDZK1 Antibodies) turnover
MAP17 1) interacts with PDZK1 (show PDZK1 Antibodies) only, 2) associates with the NH2 terminus of NaPi-IIa within the PDZK1 (show PDZK1 Antibodies)/NaPi-IIa/MAP17 complex, and 3) acts as an apical anchoring site for PDZK1 (show PDZK1 Antibodies).
the interaction between MAP17, NHERF3 (show PDZK1 Antibodies)/4, and NaPiIIa in the trans-Golgi network could be an important intermediate or alternate path in the internalization of NaPiIIa
Knockout mice for 3 members of the sodium-hydrogen regulatory factor (NHERF (show SLC9A3R1 Antibodies)) family of PDZ (show INADL Antibodies) adaptor proteins, NHERF1 (EBP50 (show SLC9A3R1 Antibodies)), NHERF2 (E3KARP (show SLC9A3R2 Antibodies)) and NHERF3 (PDZK1 (show PDZK1 Antibodies)), have helped to show that NHERF1 (show SLC9A3R2 Antibodies) is essential for both normal and mutant CFTR (show CFTR Antibodies) function [review]
Systematic analysis of Pdzk1ip1 is reported.
XPteg functions as a direct transcriptional target of RA signaling to regulate pronephric tubulogenesis in Xenopus early development
expressed specifically in kidney\; increased expression is detected in renal carcinoma
PDZK1-interacting protein 1
, 17 kDa membrane-associated protein
, PDZK1 interacting protein 1
, epithelial protein up-regulated in carcinoma, membrane associated protein 17
, membrane-associated protein 17
, membrane-associated protein 17 (Map17)
, MAP-like protein
, MAP17-like protein
, membrane-associated protein
, proximal tubules-expressed gene protein
, proximal tubules-expressing