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This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
SKI interacting protein
, nuclear protein SkiP
, nuclear protein skip
, SKI-interacting protein
, SNW domain-containing protein 1
, homolog of Drosophila BX42
, nuclear receptor coactivator NCoA-62
, nuclear receptor coactivator, 62-kD
, ski-interacting protein