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anti-Human CNOT7 Antibodies:
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Human Monoclonal CNOT7 Primary Antibody for IF, ELISA - ABIN565426
Chekulaeva, Mathys, Zipprich, Attig, Colic, Parker, Filipowicz: miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. in Nature structural & molecular biology 2011
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Cow (Bovine) Polyclonal CNOT7 Primary Antibody for IHC, WB - ABIN2780900
Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006
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Human Polyclonal CNOT7 Primary Antibody for ELISA, WB - ABIN565425
Chapat, Kolytcheff, Le Romancer, Auboeuf, De La Grange, Chettab, Sentis, Corbo: hCAF1/CNOT7 regulates interferon signalling by targeting STAT1. in The EMBO journal 2013
Results show pervasive yet nonuniform contributions of the decapping enzyme Dcp2 and the deadenylase Cnot7 to maternal mRNA clearance.
Findings suggest a preferential involvement of CNOT7 variant 2 (CNOT7v2) in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover
MEX3C associates with the cytoplasmic deadenylation complexes and ubiquitinates CNOT7.
CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by TTP in HPMEC.
CNOT7 is an antimicrobial protein and a regulator of the innate immune response.
The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.
CNOT7 is not the target tumor suppressor gene in the 8p22-23.1 colorectal cancer suppressor region.
CAF1 is a new regulator of PRMT1-dependent arginine methylation.
antiproliferative region of human Tob (residues 1-138) and intact hCaf1 were co-expressed in Escherichia coli, purified and successfully cocrystallized
Data show that Ccr4-Not function in RNA splicing and nuclear export, and that CNOT7 binds strongly with CNOT6.
Data show that efficient cell proliferation requires both CNOT7 and CNOT8, although combined knockdown of both subunits further reduces cell proliferation indicating partial redundancy between these proteins.
This study identifies CNOT7 as an important regulator of RNA transport and translation in dendrites, as well as higher cognitive function.
study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
Cnot7, a key component of deadenylation machinery, are also dormant maternal mRNAs that are recruited during oocyte maturation
Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis
MK2 phosphorylation reduces the ability of TTP to promote deadenylation by inhibiting the recruitment of CAF1 deadenylase in a mechanism that does not involve sequestration of TTP by 14-3-3.
mCAF1-deficient mouse phenotype could be linked to a defect(s) in germ cells and/or to inadequate Sertoli cell function, leading to seminiferous tubule disorganization and finally to a total disappearance of germ cells
Gene deletion of Cnot7 caused abnormal sperm morphology in Sertoli cells from knockout mice.
Cnot7 is expressed in osteoblasts and is associated with mineralization.
Cnot7 is an endogenous suppressor of bone mass in adult mice and inhibits bone mass phenotype actions
Show that a let-7 miRNA-loaded RNA-induced silencing complex interacts with the poly(A)-binding protein and the CAF1 and CCR4 deadenylases for miRNA mediated deadenylation.
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
CCR4-NOT transcription complex, subunit 7
, CCR4-NOT transcription complex subunit 7
, ccr4-not transcription complex, subunit 7
, CCR4-associated factor 1
, BTG1 binding factor 1
, BTG1-binding factor 1
, carbon catabolite repressor protein (CCR4)-associative factor 1
, POP2 homolog
, catabolite repressor protein (CCR4)-associative factor 1