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anti-Human DDX39B Antibodies:
anti-Rat (Rattus) DDX39B Antibodies:
anti-Mouse (Murine) DDX39B Antibodies:
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Human Monoclonal DDX39B Primary Antibody for CyTOF, ELISA - ABIN4363868
Boehringer, Garcia-Mansfield, Singh, Bakkar, Pirrotte, Bowser: ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export. in Scientific reports 1970
Study showed that a genetic variant in the 5' UTR (show UTS2R Antibodies) of DDX39B (show DDX39 Antibodies) reduces translation of DDX39B (show DDX39 Antibodies) mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B (show DDX39 Antibodies) variant showed strong genetic & functional epistasis with allelic variants in IL7R (show IL7R Antibodies) exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R (show IL7R Antibodies) exon 6 splicing & its impact on MS risk.
DDX39B (show DDX39 Antibodies) and its paralog DDX39A (show DDX39 Antibodies) regulate androgen receptor (show AR Antibodies) splice variant AR-V7 generation
Distinct features of RNA influence and ATPase (show DNAH8 Antibodies) efficiency between UAP56 and TcSub2 may reflect distinct structures for functional sites of TcSub2. For this reason, ligand-based or structure-based methodologies can be applied to investigate the potential of TcSub2 as a target for new drugs.
However, no significant association was observed between the DDX39B (show DDX39 Antibodies) -22 G/C polymorphism in the cases and controls. Furthermore, it is clarified that the protective effect of IL-4 (show IL4 Antibodies) -590 is independent from APOE (show APOE Antibodies) protective genotypes
The G allele of DDX39B (show DDX39 Antibodies)-22C > G was associated with absent or decreased manifestations of vivax malaria and the C allele was a risk factor for disease complications.
We unravel the role of unexplored immunologically important genes, BAT1 (show DDX39 Antibodies) and BTNL2 (show BTNL2 Antibodies), and the haplotypes of the significantly associated SNPs therein, to understand susceptibility to the disease, leprosy and its differential severity.
these data identify UAP56 as an important binding partner of Bcr (show BCR Antibodies) and a novel target for inhibiting vascular smooth muscle cell proliferation.
UAP56 and URH49 (show DDX39 Antibodies) exhibit an intrinsic CRM1 (show XPO1 Antibodies)-independent nucleocytoplasmic shuttling
Mx proteins exert their antiviral activity against IAV by interfering with the function of the RNA helicases UAP56 and URH49 (show DDX39 Antibodies)
In summary, these data demonstrate that UAP56 is utilized by influenza A viruses to prevent the formation of dsRNA and, hence, the activation of the innate immune response.
These results imply that murine leukemia virus requires UAP56, THOC5 (show THOC5 Antibodies) and THOC7 (show THOC7 Antibodies), in addition to NXF1 (show NXF1 Antibodies), for nuclear export of viral transcripts.
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. This gene belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between this gene and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene.
56 kDa U2AF65-associated protein
, ATP-dependent RNA helicase p47
, HLA-B-associated transcript 1 protein
, nuclear RNA helicase (DEAD family)
, spliceosome RNA helicase BAT1
, spliceosome RNA helicase DDX39B
, DEAD box protein UAP56
, HLA-B associated transcript 1
, HLA-B associated transcript 1A
, HLA-B-associated transcript 1A
, Nuclear RNA helicase
, spliceosome RNA helicase Bat1
, spliceosome RNA helicase Ddx39b
, DEADD box protein
, nuclear RNA helicase Bat1
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B