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Human DDX3X Protein expressed in HEK-293 Cells - ABIN2719282
Lin, Sivakumaran, Jones, Li, Harper, Wei, Jin, Rustanti, Meunier, Spann, Harrich: A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1. in Retrovirology 2015
Data suggest that L protein from LCMV interactions with host proteome, specifically DDX3X, NKRF (show NKRF Proteins), and TRIM21 (show TRIM21 Proteins). (LCMV = Lymphocytic choriomeningitis mammarenavirus; DDX3X = DEAD-box helicase 3; NKRF (show NKRF Proteins) = NF-kappa-B-repressing factor (show NKRF Proteins); TRIM21 (show TRIM21 Proteins) = tripartite motif-containing protein-21 (show TRIM21 Proteins))
DDX3 interacts extensively with RNA and ribosomal machinery to help remodel the translation landscape in response to stress, while cancer-related DDX3 variants adapt this response to selectively preserve translation
Mechanistically, increased KRAS expression induced ROS (show ROS1 Proteins) production, which elevated HIF-1alpha (show HIF1A Proteins) and YAP1 (show YAP1 Proteins) expression. Increased HIF-1alpha (show HIF1A Proteins) persistently promoted DDX3 expression via a KRAS/ROS (show ROS1 Proteins)/HIF-1alpha (show HIF1A Proteins) feedback loop.
Our study suggests that rottlerin exhibits its anti-cancer activity partly due to upregulation of DDX3 in hepatocellular carcinoma cells.
DDX3 may play an oncogenic role to promote tumor growth and invasion in colon cancer cells
data have demonstrated that Venezuelan equine encephalitis virus (VEEV)-nsP3 associates with DDX1 and DDX3 in infected cells to facilitate viral multiplication; determined that VEEV-nsP3 interacts with a pre-formed translational complex, comprising of DX3:eIF4A:eIF4G:PABP to potentially aid in translation of viral proteins.
Data suggest that DEAD-box helicase 3 (DDX3X) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein (show BLZF1 Proteins) 1 (PABPC1 (show PABPC1 Proteins)) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (via gene silencing with the CRISPR-Cas (show CSE1L Proteins) system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.
The article describes RNA remodeling activity of human DDX3X and Caenorhabditis elegans LAF (show HPD Proteins)-1 tuned by protein concentration, RNA length, and ATP.
the role of DDX3 in sarcomas
DDX3 directly regulates TRAF3 (show TRAF3 Proteins) ubiquitination and acts as a scaffold to co-ordinate assembly of signaling complexes downstream from MAVS (show MAVS Proteins).
This study demonstrated that DDX3 regulates the translation of both Prkaca and Rac1 mRNAs in neurons and therefore maintains the PKA-Rac1 signaling axis at neurite terminals for both neurite outgrowth and dendritic spine formation.
Targeted Ddx3x ablation in the epiblast leads to widespread apoptosis and abnormal growth, which causes embryonic lethality in the Sox2-cre/+;Ddx3x(flox)/Y mutant around E11.5.These results have uncovered that mouse Ddx3x is essential for both embryo and extraembryonic development
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3
, ATP-dependent RNA helicase DDX3X-like
, ATP-dependent RNA helicase DDX3X
, DEAD box protein 3, X-chromosomal
, DEAD box, X isoform
, DEAD/H box-3
, helicase like protein 2
, helicase-like protein 2
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
, ATP-dependent RNA helicase DDX3Y
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y-linked
, D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3
, D1Pas1-related sequence 2
, DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3
, DEAD box RNA helicase DEAD3
, DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2)
, embryonic RNA helicase
, fibroblast growth factor inducible 14