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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
This review consolidates current information regarding eIF2alpha phosphorylation in neurons and its impact in neurodegenerative diseases.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Stress-resistant translation of c-Src (show SRC ELISA Kits) mRNA is mediated by eIF2A (show EIF2S1 ELISA Kits).
GHRH (show GHRH ELISA Kits) and GHRH-R (show GHRHR ELISA Kits) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (show AKT1 ELISA Kits) and eIF2a (show EIF2S1 ELISA Kits) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (show EIF2S1 ELISA Kits) by GADD34 (show PPP1R15A ELISA Kits) plays an important role in doxorubicin resistance of MCF-7/ADR (show AKR1B1 ELISA Kits) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a, which is mediated by continual activation of PKR and degradation of PP1.
We identified EIF2A (show EIF2S1 ELISA Kits) phosphorylation as a novel early molecular event occurring in response to NAMPT (show NAMPT ELISA Kits) inhibition and mediating protein synthesis arrest.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
Caspase (show CASP3 ELISA Kits)(s)-dependent proteolysis of molecular chaperones and eIF2alpha may be novel signaling pathways of apoptosis.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (show PPP1CA ELISA Kits) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (show ATF4 ELISA Kits) expression. (eIF2a = eukaryotic initiation factor-2alpha (show EIF2S1 ELISA Kits); PPP1CA (show PPP1CA ELISA Kits) = protein phosphatase 1 catalytic subunit alpha; Atf4 (show ATF4 ELISA Kits) = activating transcription factor 4 (show ATF4 ELISA Kits))
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (show EIF3K ELISA Kits) eukaryotic translation initiation factor 2alpha (show EIF2S1 ELISA Kits) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (show FGF21 ELISA Kits)-mediated non-cell-autonomous energy metabolism.
PGRN (show GRN ELISA Kits) is a key regulator of insulin (show INS ELISA Kits) resistance and PGRN (show GRN ELISA Kits) may mediate its effects, at least in part, by inducing ER stress via the PERK (show EIF2AK3 ELISA Kits)-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 (show ATF4 ELISA Kits) axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
In conclusion, the immediate-early (show JUN ELISA Kits) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor eIF2alpha.
Therapeutic modulation of eIF2alpha (show EIF2S1 ELISA Kits) phosphorylation rescues TDP-43 (show TARDBP ELISA Kits) toxicity in amyotrophic lateral sclerosis disease models.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic initiation factor 2alpha
, eukaryotic translation initiation factor 2
, eukaryotic translation initiation factor 2alpha
, minute (1) 14C