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Browse our EIF2A Proteins (EIF2A)

Full name:: Eukaryotic Translation Initiation Factor 2A, 65kDa Proteins (EIF2A)

On www.antibodies-online.com are 6 Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) Proteins from 3 different suppliers available. Additionally we are shipping EIF2A Antibodies (157) and EIF2A Kits (18) and many more products for this protein. A total of 184 EIF2A products are currently listed.

Synonyms:: ATEIF2-A2, CG9946, D030048D22, D3Ertd194e, DDBDRAFT_0185936, DDBDRAFT_0234177, DDB_0185936, DDB_0234177, deIF2alpha, Dmel\\CG9946, eIF-2, eIF-2 a, eIF-2 alpha, EIF-2A, eiF-2alpha, eIF2 alpha, EIF2-A2, eIF2-alpha, eIF2a, eIF2alpha, elF2alpha, eukaryotic translation initiation factor 2 alpha subunit, IF2A_DROME, im:7145971, l(1)14Cf, l(1)19-153, M(1)8e3-10, M(1)14C, M(1)19-153, MST089, MSTP004, MSTP089, zgc:110460

list all proteins	Gene Name	GeneID	UniProt
	EIF2A	83939	Q9BY44
	EIF2A	229317	Q8BJW6
Rat EIF2A	EIF2A	502531
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EIF2A Proteins (EIF2A) by Origin

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More Proteins for EIF2A Interaction Partners

Arabidopsis thaliana Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Analysis of wild-type and GT8359 (null mutant for AtGCN2) plants infected with Turnip yellow mosaic virus or Turnip crinkle virus showed that AteIF2alpha was not phosphorylated.

Human Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

PERK activation augments respiratory SCs. The PERK-eIF2alpha-ATF4 axis increases supercomplex assembly factor 1 (SCAF1 or COX7A2L), promoting SCs and enhanced mitochondrial respiration. PERK activation is sufficient to rescue bioenergetic defects caused by complex I missense mutations derived from mitochondrial disease patients.
the endogenously produced product of inflammation, 15-deoxy-Delta(12,14)-prostaglandin J2 (15-d-PGJ2), triggers eIF2alpha phosphorylation, thereby activating the ISR, repressing bulk translation, and triggering SG formation.
Our studies suggested that chelerythrine (CHE) possibly induces apoptosis through the nuclear translocation of MLKL and *MLKL, which is promoted by a mutual regulation between MLKL and PERK-eIF2alpha pathway in response to ROS formation. The present study clarified the new function of MLKL in apoptosis.
Data show that high level of pancreatic endoplasmic reticulum kinase (PERK) and eukaryotic translation initiation factor 2A (p-eIF2[alpha]) expression in patients with pancreatic ductal adenocarcinoma (PDAC) correlated with poor survival.
The data also support a potential role for the PERK/eIF2a/ATF4 axis in modulating cell viability in irradiated glioblastoma multiforme (GBM). The dual function of PERK as a mediator of survival and death may be exploited to enhance the efficacy of radiation therapy.
Study shows an anti-tumor function of the protein kinase PKR and its substrate eIF2alpha in a HER2+ breast cancer patient-derived xenograft mouse model. The anti-tumor function depends on the transcription factor ATF4, which upregulates the CDK inhibitor P21/CIP1 and activates JNK1/2. Also, the findings show that increased eIF2alpha-P is a surrogate biomarker of trastuzumab treatment.
Data suggest that neither eIF2A nor eIF2D are involved in the translation of this Sindbis virus subgenomic mRNA (sgmRNA) bearing non-AUG codons.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation.
POSTN may function as a protective factor for osteoblasts during this process by inhibiting the eIF2alphaATF4 pathway.
findings indicate that MSI1 plays a leading role in stress granule formation that grants cancer stem cell properties and chemoresistant stress granules in GBM, in response to stressful conditions via the PKR/eIF2alpha signalling cascade.
There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a-reg2.
activation by mechanical force
FN has a role in controlling translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways

Mouse (Murine) Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

CReP deletion activates a linear signaling pathway involving eIF2alpha phosphorylation, ATF4 translation, and FGF21 induction, which promotes increased energy expenditure, and subsequently improved obesity-related metabolic parameters.
The data show that activating transcription factor 4 is not required, but eukaryotic initiation factor 2 alpha phosphorylation is necessary to prevent mTORC1 activation during amino acid stress.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP and activation of XBP-1 in RGC specifically, protects RGC somata and axons and preserves visual function.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP activation, and enhanced macrophage beclin1 dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 expression. (eIF2a = eukaryotic initiation factor-2alpha; PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 = activating transcription factor 4)
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
The role of dietary zinc in the expression of proteins involved in the endoplasmic reticulum stress response is reported.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific eukaryotic translation initiation factor 2alpha phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
PGRN is a key regulator of insulin resistance and PGRN may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
inhibition of eIF2alpha and FAK signaling may play an important role in cigarette smoking-induced lung EC apoptosis and emphysema
eIF2a phosphorylation is required for the normal function of intestinal Paneth cells and mucosal homeostasis.

Zebrafish Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.

Pig (Porcine) Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

Taken together, these results demonstrate that Porcine reproductive and respiratory syndrome virus infection induces host translation shutoff and that nsp2 is associated with this process. Both eIF2alpha phosphorylation and the attenuation of the mTOR signaling pathway contribute to the virus-induced host translation arrest.

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

Therapeutic modulation of eIF2alpha phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.

EIF2A Protein Profile

Protein Summary

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002

Alternative names and synonyms associated with EIF2A

eukaryotic translation initiation factor 2 alpha subunit (EIF2 ALPHA)
eukaryotic translation initiation factor 2A (EIF2A)
eukaryotic translation initiation factor 2A (Eif2a)
eukaryotic translation initiation factor 2A (eif2a)
eukaryotic translation initiation factor 2A (eIF2a)
eukaryotic translation initiation factor 2A, 65kDa (Eif2a)
eukaryotic translation initiation factor 2A S homeolog (eif2a.S)
eukaryotic translation initiation factor (eif2A)
eukaryotic translation initiation factor (EIF2A)
eukaryotic translation Initiation Factor 2alpha (eIF-2alpha)

ATEIF2-A2 protein
CG9946 protein
D030048D22 protein
D3Ertd194e protein
DDBDRAFT_0185936 protein
DDBDRAFT_0234177 protein
DDB_0185936 protein
DDB_0234177 protein
deIF2alpha protein
Dmel\\CG9946 protein
eIF-2 protein
eIF-2 a protein
eIF-2 alpha protein
EIF-2A protein
eiF-2alpha protein
eIF2 alpha protein
EIF2-A2 protein
eIF2-alpha protein
eIF2a protein
eIF2alpha protein
elF2alpha protein
eukaryotic translation initiation factor 2 alpha subunit protein
IF2A_DROME protein
im:7145971 protein
l(1)14Cf protein
l(1)19-153 protein
M(1)8e3-10 protein
M(1)14C protein
M(1)19-153 protein
MST089 protein
MSTP004 protein
MSTP089 protein
zgc:110460 protein

Protein level used designations for EIF2A

65 kDa eukaryotic translation initiation factor 2A , eukaryotic translation initiation factor 2A , eIF-2A , Eukaryotic translation initiation factor 2A , eukaryotic translation initiation factor 2A, 65kDa , eukaryotic translation initiation factor , eukaryotic translation initiation factor 2A-like , CG9946-PA , eIF-2alpha-PA , eukaryotic initiation factor 2alpha , eukaryotic translation initiation factor 2 , eukaryotic translation initiation factor 2alpha , minute (1) 14C

GENE ID	SPECIES
830430	Arabidopsis thaliana
83939	Homo sapiens
614746	Bos taurus
229317	Mus musculus
425042	Gallus gallus
502531	Rattus norvegicus
573991	Danio rerio
8624518	Dictyostelium discoideum AX4
100120837	Nasonia vitripennis
100195059	Salmo salar
398445	Xenopus laevis
470965	Pan troglodytes
477112	Canis lupus familiaris
710497	Macaca mulatta
9625673	Volvox carteri f. nagariensis
9681594	Micromonas pusilla CCMP1545
100050507	Equus caballus
100145715	Xenopus (Silurana) tropicalis
100338417	Oryctolagus cuniculus
100398797	Callithrix jacchus
100481938	Ailuropoda melanoleuca
100622221	Sus scrofa
100721181	Cavia porcellus
32617	Drosophila melanogaster
101119523	Ovis aries

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