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Full name:: Eukaryotic Translation Initiation Factor 2A, 65kDa Proteins (EIF2A)

On www.antibodies-online.com are 6 Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) Proteins from 3 different suppliers available. Additionally we are shipping EIF2A Antibodies (156) and EIF2A Kits (17) and many more products for this protein. A total of 184 EIF2A products are currently listed.

Synonyms:: 35kDa, 0910001O23Rik, 2410026C18Rik, ATEIF2-A2, CG9946, D030048D22, D3Ertd194e, DDBDRAFT_0185936, DDBDRAFT_0234177, DDB_0185936, DDB_0234177, deIF2alpha, Dmel\\CG9946, eIF-2, eIF-2 a, eIF-2 alpha, EIF-2A, eiF-2alpha, EIF2, eIF2 alpha, EIF2-A2, eIF2-alpha, eIF2a, Eif2alpha, elF2alpha, eukaryotic translation initiation factor 2 alpha subunit, IF2A_DROME, im:7145971, l(1)14Cf, l(1)19-153, M(1)8e3-10, M(1)14C, M(1)19-153, MST089, MSTP004, MSTP089, zgc:110460

list all proteins	Gene Name	GeneID	UniProt
	EIF2A	1965	P05198
Rat EIF2A	EIF2A	54318	P68101
	EIF2A	13665	Q6ZWX6
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EIF2A Proteins (EIF2A) by Origin

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More Proteins for EIF2A Interaction Partners

Human Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2alpha phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.
eukaryotic elongation factor 2 (show EEF2 Proteins) has a role in proliferation and invasion of lung squamous cell carcinoma
Increased phosphorylation of eIF2alpha in chronic myeloid leukemia (show BCL11A Proteins) cells stimulates secretion of matrix modifying enzymes.
a novel, positive role for PKR activation and eIF2alpha phosphorylation in human globin mRNA splicing, is reported.
Data show that eIF2Balpha and eIF2Bbeta bind to adjacent surfaces on eIF2alpha-N-terminal domains (NTDs).
Data show that eIF5 (show EIF5 Proteins)-mimic protein (5MP) represses non-AUG translation by competing with translation initiation factor (show TIF1 Proteins) 5 (eIF5 (show EIF5 Proteins)) for the Met-tRNAi-binding factor eIF2 (show EIF2S1 Proteins).
This review consolidates current information regarding eIF2alpha phosphorylation in neurons and its impact in neurodegenerative diseases.
The PERK (show EIF2AK3 Proteins)-eIF2alpha-ATF4 (show ATF4 Proteins)-CHOP (show DDIT3 Proteins) signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
These data indicate that PERK (show EIF2AK3 Proteins) regulates radioresistance in oropharyngeal carcinoma through NF-kB activation-mediated phosphorylation of eIF2alpha
The stem-loop of noncoding RNA 886 is structural feature not only critical for inhibiting PKR (show PKLR Proteins) autophosphorylation, but also the phosphorylation of its cellular substrate, EIF-2alpha (show EIF2S1 Proteins).

Arabidopsis thaliana Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.

Cow (Bovine) Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

Caspase (show CASP3 Proteins)(s)-dependent proteolysis of molecular chaperones and eIF2alpha may be novel signaling pathways of apoptosis.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP (show DDIT3 Proteins) and activation of XBP-1 (show XBP1 Proteins) in RGC specifically, protects RGC somata and axons and preserves visual function.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP (show DDIT3 Proteins) activation, and enhanced macrophage beclin1 (show BECN1 Proteins) dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK (show EIF2AK3 Proteins) coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 (show PPP1R15A Proteins) complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
We hypothesize that the essential role of methionine-charged initiator tRNA in forming ternary complex is responsible for the robust ability of methionine deficiency to induce ATF4 (show ATF4 Proteins) and the ISR even in the absence of GCN2 (show EIF2AK4 Proteins) or eIF2alpha kinase activity.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (show PPP1CA Proteins) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (show ATF4 Proteins) expression. (eIF2a = eukaryotic initiation factor-2alpha (show EIF2S1 Proteins); PPP1CA (show PPP1CA Proteins) = protein phosphatase 1 catalytic subunit alpha; Atf4 (show ATF4 Proteins) = activating transcription factor 4 (show ATF4 Proteins))
ER stress-induced increase in ATF4 (show ATF4 Proteins) and CHOP (show DDIT3 Proteins) expression is initiated by an increase in Atf4 (show ATF4 Proteins) and Chop (show DDIT3 Proteins) mRNA, which is also dependent upon eIF2alpha phosphorylation.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.

Zebrafish Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.

Pig (Porcine) Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

In conclusion, the immediate-early (show JUN Proteins) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor eIF2alpha.

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A) interaction partners

Therapeutic modulation of eIF2alpha (show EIF2S1 Proteins) phosphorylation rescues TDP-43 (show TARDBP Proteins) toxicity in amyotrophic lateral sclerosis disease models.

EIF2A Protein Profile

Protein Summary

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002

Alternative names and synonyms associated with EIF2A

eukaryotic translation initiation factor 2 subunit alpha (EIF2S1)
eukaryotic translation initiation factor 2 alpha subunit (EIF2 ALPHA)
eukaryotic translation initiation factor 2 subunit alpha (Eif2s1)
eukaryotic translation initiation factor 2A (EIF2A)
eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1)
eukaryotic translation initiation factor 2A (Eif2a)
eukaryotic translation initiation factor 2A (eif2a)
eukaryotic translation initiation factor 2A (eIF2a)
eukaryotic translation initiation factor 2A, 65kDa (Eif2a)
eukaryotic translation initiation factor 2A S homeolog (eif2a.S)
eukaryotic translation initiation factor (eif2A)
eukaryotic translation initiation factor (EIF2A)
eukaryotic translation Initiation Factor 2alpha (eIF-2alpha)

35kDa protein
0910001O23Rik protein
2410026C18Rik protein
ATEIF2-A2 protein
CG9946 protein
D030048D22 protein
D3Ertd194e protein
DDBDRAFT_0185936 protein
DDBDRAFT_0234177 protein
DDB_0185936 protein
DDB_0234177 protein
deIF2alpha protein
Dmel\\CG9946 protein
eIF-2 protein
eIF-2 a protein
eIF-2 alpha protein
EIF-2A protein
eiF-2alpha protein
EIF2 protein
eIF2 alpha protein
EIF2-A2 protein
eIF2-alpha protein
eIF2a protein
Eif2alpha protein
elF2alpha protein
eukaryotic translation initiation factor 2 alpha subunit protein
IF2A_DROME protein
im:7145971 protein
l(1)14Cf protein
l(1)19-153 protein
M(1)8e3-10 protein
M(1)14C protein
M(1)19-153 protein
MST089 protein
MSTP004 protein
MSTP089 protein
zgc:110460 protein

Protein level used designations for EIF2A

, , , , , , , , , , , , , , , , , , , eIF-2-alpha eukaryotic translation initiation factor 2 subunit 1 eukaryotic translation initiation factor 2 subunit alpha EIF-2A EIF-2alpha 65 kDa eukaryotic translation initiation factor 2A eukaryotic translation initiation factor 2A eIF-2A eIF-2alpha Eukaryotic translation initiation factor 2A eukaryotic translation initiation factor 2A, 65kDa eukaryotic translation initiation factor eukaryotic translation initiation factor 2A-like eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa CG9946-PA eIF-2alpha-PA eukaryotic initiation factor 2alpha eukaryotic translation initiation factor 2 eukaryotic translation initiation factor 2alpha minute (1) 14C

GENE ID	SPECIES
1965	Homo sapiens
830430	Arabidopsis thaliana
54318	Rattus norvegicus
83939	Homo sapiens
327694	Bos taurus
423279	Gallus gallus
614746	Bos taurus
13665	Mus musculus
229317	Mus musculus
425042	Gallus gallus
502531	Rattus norvegicus
573991	Danio rerio
8624518	Dictyostelium discoideum AX4
100120837	Nasonia vitripennis
100195059	Salmo salar
398445	Xenopus laevis
470965	Pan troglodytes
477112	Canis lupus familiaris
710497	Macaca mulatta
9625673	Volvox carteri f. nagariensis
9681594	Micromonas pusilla CCMP1545
100050507	Equus caballus
100145715	Xenopus (Silurana) tropicalis
100338417	Oryctolagus cuniculus
100398797	Callithrix jacchus
100481938	Ailuropoda melanoleuca
100339093	Oryctolagus cuniculus
100622221	Sus scrofa
100721181	Cavia porcellus
100155472	Sus scrofa
32617	Drosophila melanogaster
101119523	Ovis aries

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