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Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2alpha phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.
eukaryotic elongation factor 2 (show EEF2 Proteins) has a role in proliferation and invasion of lung squamous cell carcinoma
Increased phosphorylation of eIF2alpha in chronic myeloid leukemia (show BCL11A Proteins) cells stimulates secretion of matrix modifying enzymes.
a novel, positive role for PKR activation and eIF2alpha phosphorylation in human globin mRNA splicing, is reported.
Data show that eIF2Balpha and eIF2Bbeta bind to adjacent surfaces on eIF2alpha-N-terminal domains (NTDs).
Data show that eIF5 (show EIF5 Proteins)-mimic protein (5MP) represses non-AUG translation by competing with translation initiation factor (show TIF1 Proteins) 5 (eIF5 (show EIF5 Proteins)) for the Met-tRNAi-binding factor eIF2 (show EIF2S1 Proteins).
This review consolidates current information regarding eIF2alpha phosphorylation in neurons and its impact in neurodegenerative diseases.
The PERK (show EIF2AK3 Proteins)-eIF2alpha-ATF4 (show ATF4 Proteins)-CHOP (show DDIT3 Proteins) signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
These data indicate that PERK (show EIF2AK3 Proteins) regulates radioresistance in oropharyngeal carcinoma through NF-kB activation-mediated phosphorylation of eIF2alpha
The stem-loop of noncoding RNA 886 is structural feature not only critical for inhibiting PKR (show PKLR Proteins) autophosphorylation, but also the phosphorylation of its cellular substrate, EIF-2alpha (show EIF2S1 Proteins).
The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Caspase (show CASP3 Proteins)(s)-dependent proteolysis of molecular chaperones and eIF2alpha may be novel signaling pathways of apoptosis.
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP (show DDIT3 Proteins) and activation of XBP-1 (show XBP1 Proteins) in RGC specifically, protects RGC somata and axons and preserves visual function.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP (show DDIT3 Proteins) activation, and enhanced macrophage beclin1 (show BECN1 Proteins) dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK (show EIF2AK3 Proteins) coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 (show PPP1R15A Proteins) complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
We hypothesize that the essential role of methionine-charged initiator tRNA in forming ternary complex is responsible for the robust ability of methionine deficiency to induce ATF4 (show ATF4 Proteins) and the ISR even in the absence of GCN2 (show EIF2AK4 Proteins) or eIF2alpha kinase activity.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (show PPP1CA Proteins) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (show ATF4 Proteins) expression. (eIF2a = eukaryotic initiation factor-2alpha (show EIF2S1 Proteins); PPP1CA (show PPP1CA Proteins) = protein phosphatase 1 catalytic subunit alpha; Atf4 (show ATF4 Proteins) = activating transcription factor 4 (show ATF4 Proteins))
ER stress-induced increase in ATF4 (show ATF4 Proteins) and CHOP (show DDIT3 Proteins) expression is initiated by an increase in Atf4 (show ATF4 Proteins) and Chop (show DDIT3 Proteins) mRNA, which is also dependent upon eIF2alpha phosphorylation.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
In conclusion, the immediate-early (show JUN Proteins) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor eIF2alpha.
Therapeutic modulation of eIF2alpha (show EIF2S1 Proteins) phosphorylation rescues TDP-43 (show TARDBP Proteins) toxicity in amyotrophic lateral sclerosis disease models.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, 65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic initiation factor 2alpha
, eukaryotic translation initiation factor 2
, eukaryotic translation initiation factor 2alpha
, minute (1) 14C