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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation.
POSTN (show POSTN Proteins) may function as a protective factor for osteoblasts during this process by inhibiting the eIF2alphaATF4 pathway.
findings indicate that MSI1 (show MSI1 Proteins) plays a leading role in stress granule formation that grants cancer stem cell properties and chemoresistant stress granules in GBM, in response to stressful conditions via the PKR (show PKLR Proteins)/eIF2alpha signalling cascade.
There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a (show EIF2S1 Proteins)-reg2 (show FLOT1 Proteins).
ER stress is induced early in EAE and that modulation of ER stress by inhibition of eIF2alpha-CHOP (show DDIT3 Proteins) and activation of XBP-1 (show XBP1 Proteins) in RGC specifically, protects RGC somata and axons and preserves visual function.
alpha-asarone abrogated 7beta-hydroxycholesterol-triggered eIF2alpha-CHOP (show DDIT3 Proteins) activation, and enhanced macrophage beclin1 (show BECN1 Proteins) dependent autophagy.
In response to endoplasmic reticulum stress, activation of PERK (show EIF2AK3 Proteins) coordinates the integrated stress response by phosphorylating eIF2alpha, which is then quickly dephosphorylated by the GADD34 (show PPP1R15A Proteins) complex. Data imply dual role of the ISR in promoting and inhibiting medulloblastoma tumorigenesis.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (show PPP1CA Proteins) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (show ATF4 Proteins) expression. (eIF2a = eukaryotic initiation factor-2alpha (show EIF2S1 Proteins); PPP1CA (show PPP1CA Proteins) = protein phosphatase 1 catalytic subunit alpha; Atf4 (show ATF4 Proteins) = activating transcription factor 4 (show ATF4 Proteins))
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
Taken together, these results demonstrate that Porcine reproductive and respiratory syndrome virus infection induces host translation shutoff and that nsp2 (show RTN2 Proteins) is associated with this process. Both eIF2alpha phosphorylation and the attenuation of the mTOR (show FRAP1 Proteins) signaling pathway contribute to the virus-induced host translation arrest.
Therapeutic modulation of eIF2alpha (show EIF2S1 Proteins) phosphorylation rescues TDP-43 (show TARDBP Proteins) toxicity in amyotrophic lateral sclerosis disease models.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, eukaryotic initiation factor 2alpha
, eukaryotic translation initiation factor 2
, eukaryotic translation initiation factor 2alpha
, minute (1) 14C