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Human Polyclonal Nucleolin Primary Antibody for ChIP, EM - ABIN153181
Hanakahi, Dempsey, Li, Maizels: Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 17 Pubmed References
Human Polyclonal Nucleolin Primary Antibody for ICC, IF - ABIN151419
Wu, Shen, Newburger: Recognition and binding of the human selenocysteine insertion sequence by nucleolin. in Journal of cellular biochemistry 2000
Show all 2 Pubmed References
Human Polyclonal Nucleolin Primary Antibody for IHC, IP - ABIN151659
Tan, Glen, Töpf, Hall, OSullivan, Sneddon, Wren, Avery, Lewis, ten Dijke, Arthur, Goodship, Keavney: Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. in Human mutation 2012
nucleolin interacts with the viral nucleoprotein
This review focus on the contribution of nucleolin for cancer disease and on the development of therapeutic strategies targeting this protein. [review]
Results found that prostate circulating tumor cells (CTCs) as a population have an increased level of total nucleolin expression compared to white blood cells. Additionally, there was a distinct nucleolin staining pattern and localization in CTCs.
this results show that nucleolin increases colony formation and anchorage-independent growth of ErbB2 (show ERBB2 Antibodies)-overexpressing cells, and that nucleolin overexpression in ErbB2 (show ERBB2 Antibodies)-positive breast cancer patients is associated with reduced patient survival rates and increased disease-risk
C23 has a role in promoting tumorigenesis via suppressing p53 (show TP53 Antibodies) activity
NCL (show CLN5 Antibodies) was associated with bipolar disorder.
Nucleolin both forms an mRNP complex with the eIF4G (show EIF4G1 Antibodies) and CSF-1 (show CSF1 Antibodies) mRNA, and is co-localized with the eIF4G (show EIF4G1 Antibodies) in the cytoplasm further supporting nucleolin's role in translational regulation.
Identified the regulator of ribosome production nucleolin (NCL) as over-expressed in AML (show RUNX1 Antibodies) blasts. Moreover, we found in two series that high NCL (show CLN5 Antibodies) mRNA expression level was associated with a poor overall survival, particular in elderly patients.
Data suggest a 216-nucleotide proximal cis (show CISH Antibodies)-element in LIF (show LIF Antibodies) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH Antibodies)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin and PCBP1 (show PCBP1 Antibodies), 2 trans-acting factors that bind to and stabilize LIF (show LIF Antibodies) mRNA. [LIF (show LIF Antibodies) = leukemia inhibitory factor (show LIF Antibodies); PCBP1 (show PCBP1 Antibodies) = poly(rC) binding protein 1 (show PCBP1 Antibodies)]
Data suggest that C11orf98 microprotein, NPM1 (show NPM1 Antibodies), and nucleolin interact and colocalize in the cell nucleolus. (C11orf98 = chromosome 11 open reading frame 98 protein; NPM1 (show NPM1 Antibodies) = nucleophosmin 1 (show NPM1 Antibodies))
Mitochondrial catalase (show CAT Antibodies) induces neoplastic cell transformation through nucleolin-dependent Cox-2 (show COX2 Antibodies) mRNA stabilization.
subcellular sequestration of nucleolin or importin beta1 enhances axonal growth and causes a subcellular shift in protein synthesis
Data indicate alpha-P85 (show ECM1 Antibodies) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR (show EGFR Antibodies)) expression and cell malignant transformation via nucleolin-dependent mechanism.
nucleolin inhibition is a new anti-pancreatic cancer therapeutic strategy that dually blocks tumor progression and normalizes tumor vasculature in pancreatic ductal adenocarcinoma
Nucleolin protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 (show ABCA1 Antibodies) expression.
Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages
Nucleolin is a receptor for maleylated-bovine serum albumin (show ALB Antibodies) on macrophages
Lrrc34, a novel nucleolar protein (show MCRS1 Antibodies), interacts with npm1 (show GJA1 Antibodies) and ncl and has an impact on pluripotent stem cells
results indicate that nucleolin is a receptor that allows macrophages to recognize toxic Advanced glycosylation end-products.
results for the first time demonstrate that nucleolin-SUMO at K294R plays a critical role in its nucleus sequestration and gadd45alpha (show GADD45A Antibodies) mRNA binding activity.
Data show that si-RNA induced down-regulation of FUT1 (show FUT1 Antibodies) and FUT2 (show FUT2 Antibodies) reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
Suggest that during heart disease nucleolin is reactivated to mobilize conserved aspects of chromatin remodeling and gene expression.
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
, protein C23