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anti-Human Nucleolin Antibodies:
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Human Polyclonal Nucleolin Primary Antibody for ChIP, EM - ABIN153181
Hanakahi, Dempsey, Li, Maizels: Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 19 Pubmed References
Polyclonal Nucleolin Primary Antibody for IHC (fro), IF - ABIN540666
Novoselov, Kryukov, Xu, Carlson, Hatfield, Gladyshev: Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. in The Journal of biological chemistry 2007
Show all 5 Pubmed References
Human Polyclonal Nucleolin Primary Antibody for ICC, IF - ABIN151419
Wu, Shen, Newburger: Recognition and binding of the human selenocysteine insertion sequence by nucleolin. in Journal of cellular biochemistry 2000
Show all 2 Pubmed References
Human Polyclonal Nucleolin Primary Antibody for IHC, IP - ABIN151659
Tan, Glen, Töpf, Hall, OSullivan, Sneddon, Wren, Avery, Lewis, ten Dijke, Arthur, Goodship, Keavney: Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation. in Human mutation 2012
High nucleolin expression is associated with hematogical malignancy.
NCL-NPM complex formation is completely abolished by the mutation and that the presence/absence of the interaction is not affected by drugs causing genotoxic stress or differentiation. Deregulation resulting from changes of NCL/NPMwt ratio may contribute to leukemogenesis.
This integrated transcriptomic analysis uncovers new unexpected roles for nucleolin in metabolic regulation and signaling pathways paving the way to better understand the global function of nucleolin within the cell.
NCL and Sam68 could recognize their specific motifs and directly bind to EXON1 of CYTOR. Moreover, EXON1 was the key functional site mediating the interaction of CYTOR with NCL and Sam68. NCL and Sam68 functioned as oncogenes to promote colorectal cancer (CRC) progression. Further results confirmed that the heterotrimeric complex of CYTOR, NCL and Sam68 activated the NF-kappaB pathway and EMT to contribute to CRC progr...
the inhibition of HDAC activity by suberoylanilide hydroxamic acid rescued NCL acetylation accompanied by the loss of mouse double minute 2 homolog (MDM2)-mediated ubiquitination.
CITED2 acts as a molecular chaperone to guide PRMT5 and p300 to nucleolin, thereby activating nucleolin. Informatics and experimental data suggest that the CITED2-nucleolin axis is involved in prostate cancer metastasis.
We suggest that BTG2(/TIS21) is a potential inhibitor of nucleolin in the cytoplasm, leading to inhibition of carcinogenesis after H. pylori infection.
Data show that NCL phosphorylation offers specificity to its protein-protein, protein-RNA interactions, resulting in the PARN deadenylase regulation, and hence gene expression, during cellular stress responses.
Depletion of endogenous NCL in cells by siRNA targeting during H5N1 infection resulted in significantly increased viral polymerase activity.
nucleolin interacts with the viral nucleoprotein
This review focus on the contribution of nucleolin for cancer disease and on the development of therapeutic strategies targeting this protein. [review]
Results found that prostate circulating tumor cells (CTCs) as a population have an increased level of total nucleolin expression compared to white blood cells. Additionally, there was a distinct nucleolin staining pattern and localization in CTCs.
this results show that nucleolin increases colony formation and anchorage-independent growth of ErbB2-overexpressing cells, and that nucleolin overexpression in ErbB2-positive breast cancer patients is associated with reduced patient survival rates and increased disease-risk
C23 has a role in promoting tumorigenesis via suppressing p53 activity
NCL was associated with bipolar disorder.
Nucleolin both forms an mRNP complex with the eIF4G and CSF-1 mRNA, and is co-localized with the eIF4G in the cytoplasm further supporting nucleolin's role in translational regulation.
Identified the regulator of ribosome production nucleolin (NCL) as over-expressed in AML blasts. Moreover, we found in two series that high NCL mRNA expression level was associated with a poor overall survival, particular in elderly patients.
Data suggest a 216-nucleotide proximal cis-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin and PCBP1, 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 = poly(rC) binding protein 1]
Data suggest that C11orf98 microprotein, NPM1, and nucleolin interact and colocalize in the cell nucleolus. (C11orf98 = chromosome 11 open reading frame 98 protein; NPM1 = nucleophosmin 1)
nucleolin inhibition is a new anti-pancreatic cancer therapeutic strategy that dually blocks tumor progression and normalizes tumor vasculature in pancreatic ductal adenocarcinoma
The results demonstrated prolific RSV infection of N2a cells, which triggered a decrease of NeuN protein expression, coinciding with an increase of nuclear lesions, F protein expression, RSV viral titers, and late apoptotic levels of N2a cells. RSV infection induced co-localization of RSV F protein with TLR4 and nucleolin.
The study demonstrated existence of a regulatory axis of miR-34b/nucleolin during muscle differentiation.
Mitochondrial catalase induces neoplastic cell transformation through nucleolin-dependent Cox-2 mRNA stabilization.
subcellular sequestration of nucleolin or importin beta1 enhances axonal growth and causes a subcellular shift in protein synthesis
Data indicate alpha-P85 Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR) expression and cell malignant transformation via nucleolin-dependent mechanism.
Nucleolin protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 expression.
Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages
Nucleolin is a receptor for maleylated-bovine serum albumin on macrophages
Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells
results indicate that nucleolin is a receptor that allows macrophages to recognize toxic Advanced glycosylation end-products.
results for the first time demonstrate that nucleolin-SUMO at K294R plays a critical role in its nucleus sequestration and gadd45alpha mRNA binding activity.
Nucleolin-FGF1 interaction is critical for the intranuclear phosphorylation of FGF1 by PKCdelta and thereby the regulation of nuclear export of FGF1.
ANKRD1, in association with factors such as nucleolin, represses MMP13 transcription. Ankrd1 deletion additionally relieved MMP10 transcriptional repression
Suggest that during heart disease nucleolin is reactivated to mobilize conserved aspects of chromatin remodeling and gene expression.
Nucleolin is involved in the regulation of ischemia reperfusion-induced cardiac injury and dysfunction via the regulation of Hsp32.
Data indicate that increased expression of interleukin-9 receptor (Il9R) is associated with an increased binding of nucleolin.
Data demonstrate that nucleolin is a critical regulator of ESC self-renewal and that suppression of the p53-dependent pathway is the major molecular mechanism underlying functions of nucleolin in ESCs.
nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization
Nucleolin is clearly involved in the carcinogenic process of H. pylori as a major cellular receptor of Tip-alpha protein that shuttles Tip-alpha from cell surface to cytosol and nuclei.
Data show that si-RNA induced down-regulation of FUT1 and FUT2 reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
, protein C23