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Human Nucleolin Protein expressed in HEK-293 Cells - ABIN2727708
Tosoni, Frasson, Scalabrin, Perrone, Butovskaya, Nadai, Palù, Fabris, Richter: Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription. in Nucleic acids research 2015
Show all 3 Pubmed References
Results found that prostate circulating tumor cells (CTCs) as a population have an increased level of total nucleolin expression compared to white blood cells. Additionally, there was a distinct nucleolin staining pattern and localization in CTCs.
this results show that nucleolin increases colony formation and anchorage-independent growth of ErbB2 (show ERBB2 Proteins)-overexpressing cells, and that nucleolin overexpression in ErbB2 (show ERBB2 Proteins)-positive breast cancer patients is associated with reduced patient survival rates and increased disease-risk
C23 has a role in promoting tumorigenesis via suppressing p53 (show TP53 Proteins) activity
NCL (show CLN5 Proteins) was associated with bipolar disorder.
Nucleolin both forms an mRNP complex with the eIF4G (show EIF4G1 Proteins) and CSF-1 (show CSF1 Proteins) mRNA, and is co-localized with the eIF4G (show EIF4G1 Proteins) in the cytoplasm further supporting nucleolin's role in translational regulation.
Identified the regulator of ribosome production nucleolin (NCL) as over-expressed in AML (show RUNX1 Proteins) blasts. Moreover, we found in two series that high NCL (show CLN5 Proteins) mRNA expression level was associated with a poor overall survival, particular in elderly patients.
Data suggest a 216-nucleotide proximal cis (show CISH Proteins)-element in LIF (show LIF Proteins) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH Proteins)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin and PCBP1 (show PCBP1 Proteins), 2 trans-acting factors that bind to and stabilize LIF (show LIF Proteins) mRNA. [LIF (show LIF Proteins) = leukemia inhibitory factor (show LIF Proteins); PCBP1 (show PCBP1 Proteins) = poly(rC) binding protein 1 (show PCBP1 Proteins)]
Data suggest that C11orf98 microprotein, NPM1 (show NPM1 Proteins), and nucleolin interact and colocalize in the cell nucleolus. (C11orf98 = chromosome 11 open reading frame 98 protein; NPM1 (show NPM1 Proteins) = nucleophosmin 1 (show NPM1 Proteins))
nucleolin inhibition is a new anti-pancreatic cancer therapeutic strategy that dually blocks tumor progression and normalizes tumor vasculature in pancreatic ductal adenocarcinoma
It has been found that during microtubule growth phases, nucleolin affects both the speed and life time of microtubule polymerization.
subcellular sequestration of nucleolin or importin beta1 enhances axonal growth and causes a subcellular shift in protein synthesis
Data indicate alpha-P85 (show ECM1 Proteins) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR (show EGFR Proteins)) expression and cell malignant transformation via nucleolin-dependent mechanism.
Nucleolin protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 (show ABCA1 Proteins) expression.
Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages
Nucleolin is a receptor for maleylated-bovine serum albumin (show ALB Proteins) on macrophages
Lrrc34, a novel nucleolar protein (show MCRS1 Proteins), interacts with npm1 (show GJA1 Proteins) and ncl and has an impact on pluripotent stem cells
results indicate that nucleolin is a receptor that allows macrophages to recognize toxic Advanced glycosylation end-products.
results for the first time demonstrate that nucleolin-SUMO at K294R plays a critical role in its nucleus sequestration and gadd45alpha (show GADD45A Proteins) mRNA binding activity.
Nucleolin-FGF1 interaction is critical for the intranuclear phosphorylation of FGF1 by PKCdelta and thereby the regulation of nuclear export of FGF1.
Data show that si-RNA induced down-regulation of FUT1 (show FUT1 Proteins) and FUT2 (show FUT2 Proteins) reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
Suggest that during heart disease nucleolin is reactivated to mobilize conserved aspects of chromatin remodeling and gene expression.
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
, protein C23