Browse our anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antibodies

Full name:: anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibodies (PCMT1)

On www.antibodies-online.com are 81 Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antibodies from 23 different suppliers available. Additionally we are shipping Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Proteins (14) and Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Kits (12) and many more products for this protein. A total of 109 Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase products are currently listed.

Synonyms:: C79501, etID309741.20, fj13d06, PCM, PCMT, pimt, wu:fj13d06

list all antibodies	Gene Name	GeneID	UniProt
	PCMT1	5110	P22061
	PCMT1	18537
	PCMT1	25604	P22062
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Most Popular Reactivities for anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antibodies

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Relevant Pathways for anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibodies

Ribonucleoprotein Complex Subunit Organization

More product categories related to Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibody

Top referenced anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Antibodies

Human Polyclonal PCMT1 Primary Antibody for ICC, IF - ABIN4344090 : Forsström, Axnäs, Stengele, Bühler, Albert, Richmond, Hu, Nilsson, Hudson, Rockberg, Uhlen: Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays. in Molecular & cellular proteomics : MCP 2014 (PubMed)

More Antibodies against Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase Interaction Partners

Human Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

decrease of PCMT1 significantly increased the proportion of D-Asp (show ASIP Antibodies) residues in PHB1 (show PHB Antibodies) and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system
PIMT heterozygosity for R36C, G175R, R17H, or R17S would be detrimental to successful aging, whereas homozygosity (should it ever occur) would produce devastating neuropathology
Strong PIMT expression was a predictive marker of poor prognosis for surgically resected lung adenocarcinoma.
The data of this study indicated that DA-associated PIMT downregulation is an important event contributing to neuronal cell death
ERK2 (show MAPK1 Antibodies)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 Antibodies) at Ser298 augments hepatic gluconeogenesis.
Overexpression of PCMT1 attentuates Mst1 (show MST1 Antibodies) kinase activation and its apoptotic effects in response to hypoxia-induced injury in cardiomyocytes.
Data indicate that human PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp conversion to Asp (show ASIP Antibodies), and is able to restore Arabidopsis PRH75 (show DDX46 Antibodies)'s complex biochemical activity provided isoAsp formation has not led to conformational alterations.
Data show six differentially expressed proteins were identified as HSP70 (show HSP70 Antibodies), PPIA (show PPIA Antibodies) and alpha-Enolase (up-regulated) S100-A9, PIMT and beta-5 tubulin (show TUBB Antibodies) (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis.
The results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in the Chinese population of Lvliang.
Study provides new insight into the molecular mechanisms by which PIMT suppresses the p53 (show TP53 Antibodies) activity through carboxyl methylation, and suggests a therapeutic target for cancers.

Mouse (Murine) Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

Loss of normal CKB (show CHKB Antibodies) structure and function contributes to the mechanisms by which isoaspartate accumulation leads to central nervous system dysfunction in the PIMT-Knockout mouse.
PIMT levels may significantly influence the course of age-related central nervous system dysfunction.
ERK2 (show MAPK1 Antibodies)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 Antibodies) at Ser298 augments hepatic gluconeogenesis.
PIMT knockout mice have perturbations in glutamate (show GRIN1 Antibodies) metabolism in the brain and die prematurely of epileptic seizures.
synuclein is not a major target of PIMT in vivo
Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of PCMT1 knockout mice
Recombinant adeno (show ADORA2A Antibodies)-PIMT improved the symptoms of PIMT-deficient mice in vivo, but only partially repaired IsoAsp in damaged proteins.
An accumulation of isoaspartyl residues in cells of mice lacking the isoaspartyl repair enzyme PCMT alters the effector function of T lymphocytes leading to autoantibody production.
Pcmt1-/- mice have altered regulation of the insulin (show INS Antibodies) pathway, possibly as a compensatory response to altered glucose uptake or metabolism or as an adaptive response to a general accumulation of isoaspartyl protein damage in the brain and other tissues.
Protein L-isoaspartyl methyltransferase (PIMT) catalyzes in vivo racemization of Asp (show C3 Antibodies)-25 in mammalian histone H2B, suggesting that PIMT functions in the repair, rather than the metabolic turnover, of isoaspartyl proteins in vivo.

Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antigen Profile

Antigen Summary

This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1)

protein-L-isoaspartate (D-aspartate) O-methyltransferase (PCMT1) antibody
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 (Pcmt1) antibody
protein-L-isoaspartate (D-aspartate) O-methyltransferase L homeolog (pcmt1.L) antibody
protein-L-isoaspartate(D-aspartate)O-methyltransferase (pcmt1) antibody
protein-L-isoaspartate (D-aspartate) O-methyltransferase (Pcmt1) antibody
protein-L-isoaspartate (D-aspartate) O-methyltransferase (pcmt) antibody

C79501 antibody
etID309741.20 antibody
fj13d06 antibody
PCM antibody
PCMT antibody
pimt antibody
wu:fj13d06 antibody

Protein level used designations for PCMT1

L-isoaspartyl protein carboxyl methyltransferase , protein L-isoaspartyl/D-aspartyl methyltransferase , protein-L-isoaspartate(D-aspartate) O-methyltransferase , protein-beta-aspartate methyltransferase , protein carboxyl methyltransferase , PIMT , protein carboxyl-o-methyltransferase , protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 , Protein L-isoaspartyl/D-aspartyl methyltransferase , Protein-beta-aspartate methyltransferase , l-isoaspartyl protein carboxyl methyltransferase

GENE ID	SPECIES
5110	Homo sapiens
18537	Mus musculus
25604	Rattus norvegicus
428607	Gallus gallus
476242	Canis lupus familiaris
100502562	Sus scrofa
613854	Bos taurus
495685	Xenopus laevis
100172708	Pongo abelii
380580	Xenopus laevis
100731541	Cavia porcellus
30751	Danio rerio

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Show all anti-Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) Antibodies with Pubmed References

Human Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

Mouse (Murine) Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1) interaction partners

Antigen Summary

Alternative names and synonyms associated with Protein-L-Isoaspartate (D-Aspartate) O-Methyltransferase (PCMT1)

Protein level used designations for PCMT1