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Pum2 serves key functions in the adult mammalian central nervous system encompassing neuronal excitability and behavioral response to environmental challenges
PUM2 binds to AChE mRNA and regulates AChE expression translationally at the neuromuscular synapse.
P2P-R (show RBBP6 Proteins) expression may be translationally regulated by PUM2
Data show that Pumilio-2 is expressed most abundantly in germ cells with the highest expression in undifferentiated gonocytes and spermatogonia.
1.6A resolution X-ray crystal structure of the Puf (show NME1 Proteins) domain from murine Pum2 was presented.
A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1 (show PUM1 Proteins).
results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1 (show PUM1 Proteins)/2 and FOXP1 (show FOXP1 Proteins) in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.
The study shows that pseudouridine and N(6)-methyladenosine weaken the binding of the human single-stranded RNA binding protein (show PTBP1 Proteins) Pumilio 2 (hPUM2) to its consensus motif.
Pumilios (including PUM1 (show PUM1 Proteins) and PUM2) are RNA-binding proteins with Puf domains made up of 8 poorly conserved Puf repeats, 3 helix bundles arranged in rainbow architecture, where each repeat recognizes a single base of the RNA-binding sequence. [REVIEW]
Identification of NORAD-interacting proteins revealed that this lncRNA functions as a multivalent binding platform for PUM (show MYOD1 Proteins) proteins, with the capacity to sequester a significant fraction of the total cellular pool of PUM1 (show PUM1 Proteins) and PUM2. Studies reveal unanticipated roles for a lncRNA and PUMILIO proteins in the maintenance of genomic stability.
PUM2 does not repress differentiation of adipose-derived stem cells (ASCs) but rather is involved in the positive control of ASCs division and proliferation.
human Pumilio homologs Pum 1 and Pum 2 repress the translation of E2F3 by binding to the E2F3 3' untranslated region (UTR) and also enhance the activity of multiple E2F3 targeting microRNAs (miRNAs)
Mammalian PUM2-Ago-eEF1A (show EEF1A1 Proteins) inhibited translation of nonadenylated and polyadenylated reporter mRNAs in vitro.
NANOS1 (show NANOS1 Proteins)-PUMILIO2 complex, together with GEMIN3 (show DDX20 Proteins) and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells.
in mitosis, PUM2 physically associates with Aurora-A (show AURKA Proteins) to ensure enough active Aurora-A (show AURKA Proteins) at centrosomes for mitotic entry
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts (By similarity).
, pumilio homolog 2
, pumilio 2