-
RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD).
-
results provide evidence that RBM10 expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value
-
the mechanism of action of RBM5-AS1 in the WNT pathway via physical interactions with beta-catenin, helping organize transcriptional complexes that sustain colon cancer-initiating cells function.
-
Low RBM5 expression was significantly associated with gliomas.
-
RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer
-
Results show that RBM5 is downregulated in smoke induced tumor; its overexpression inhibits tumor growth through cell cycle arrest and induction of apoptosis suggesting the importance of RBM5 in the pathogenesis of smoking-related cancer.
-
ICG-001 had no apparent effect on the RBM5 levels.
-
RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine.
-
Antagonizes the effects of RBM5, RBM6, and RBM10 in cell colony formation.
-
Loss of RBM5 expression is associated with lung adenocarcinoma.
-
expression of RBM5 protein was significantly decreased in cancerous prostatic tissues compared to the normal tissues
-
RBM5 can inhibit the growth of lung cancer cells and induce apoptosis both in vitro and in vivo.
-
Expression of RBM5 mRNA and protein was negatively correlated with expression of EGFR and KRAS mRNA and protein in NSCLC tissues.
-
RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract.
-
RBM5 may serve as a biomarker with the ability to predict a response to cisplatin
-
The results suggest that RBM5 expression is not directly regulated by EGFR in non-smoker related lung adenocarinomas.
-
NMR data analysis of RBM5 RRM2 reveals several features of protein-RNA interfaces. The most striking observation is the presence of two preferred target RNA sequences, the sequences [5'-(CUCUUC)-3'] and [5'-(GAGAAG)-3'].
-
Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner.
-
alters expression of genes involved in metastasis
-
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.
