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RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD).
results provide evidence that RBM10 expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value
the mechanism of action of RBM5-AS1 in the WNT pathway via physical interactions with beta-catenin, helping organize transcriptional complexes that sustain colon cancer-initiating cells function.
Low RBM5 expression was significantly associated with gliomas.
RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer
Results show that RBM5 is downregulated in smoke induced tumor; its overexpression inhibits tumor growth through cell cycle arrest and induction of apoptosis suggesting the importance of RBM5 in the pathogenesis of smoking-related cancer.
ICG-001 had no apparent effect on the RBM5 levels.
RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine.
Antagonizes the effects of RBM5, RBM6, and RBM10 in cell colony formation.
Loss of RBM5 expression is associated with lung adenocarcinoma.
expression of RBM5 protein was significantly decreased in cancerous prostatic tissues compared to the normal tissues
RBM5 can inhibit the growth of lung cancer cells and induce apoptosis both in vitro and in vivo.
Expression of RBM5 mRNA and protein was negatively correlated with expression of EGFR and KRAS mRNA and protein in NSCLC tissues.
RBM5 promotes exon 4 skipping of AID pre-mRNA by competing with the binding of U2AF65 to the polypyrimidine tract.
RBM5 may serve as a biomarker with the ability to predict a response to cisplatin
The results suggest that RBM5 expression is not directly regulated by EGFR in non-smoker related lung adenocarinomas.
NMR data analysis of RBM5 RRM2 reveals several features of protein-RNA interfaces. The most striking observation is the presence of two preferred target RNA sequences, the sequences [5'-(CUCUUC)-3'] and [5'-(GAGAAG)-3'].
Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner.
alters expression of genes involved in metastasis
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.
Expression of Rbm5 and Rbm10 RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
The RBM5/10 staining was higher 48 to 72 hours after traumatic brain injury and appeared to be increased in neuronal nuclei of the hippocampus.
Our findings also suggest that the second RRM of RBM5 is pivotal for appropriate pre-mRNA splicing.
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.
RNA binding motif protein 5
, RNA-binding motif protein 5-B
, RNA-binding protein 5-B
, RNA-binding motif protein 5
, RNA-binding protein 5
, RNA-binding protein 5-like
, RNA-binding motif protein 5-A
, RNA-binding protein 5-A
, putative tumor suppressor LUCA15
, renal carcinoma antigen NY-REN-9
, G15 protein
, tumor suppressor LUCA15