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RNA binding motif protein 10 (RBM10 (show RBM10 Proteins)) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD).
results provide evidence that RBM10 (show RBM10 Proteins) expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 (show RBM10 Proteins) and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value
the mechanism of action of RBM5-AS1 (show PTGDR Proteins) in the WNT (show WNT2 Proteins) pathway via physical interactions with beta-catenin (show CTNNB1 Proteins), helping organize transcriptional complexes that sustain colon cancer-initiating cells function.
Low RBM5 expression was significantly associated with gliomas.
RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 (show TP53 Proteins) target gene p21 (show CDKN1A Proteins). Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer
Results show that RBM5 is downregulated in smoke induced tumor; its overexpression inhibits tumor growth through cell cycle arrest and induction of apoptosis suggesting the importance of RBM5 in the pathogenesis of smoking-related cancer.
ICG-001 had no apparent effect on the RBM5 levels.
RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine.
Antagonizes the effects of RBM5, RBM6 (show RBM6 Proteins), and RBM10 (show RBM10 Proteins) in cell colony formation.
Loss of RBM5 expression is associated with lung adenocarcinoma.
Expression of Rbm5 and Rbm10 (show RBM10 Proteins) RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
The RBM5/10 staining was higher 48 to 72 hours after traumatic brain injury and appeared to be increased in neuronal nuclei (show RBFOX3 Proteins) of the hippocampus.
Our findings also suggest that the second RRM of RBM5 is pivotal for appropriate pre-mRNA splicing.
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer.
RNA binding motif protein 5
, RNA-binding motif protein 5-B
, RNA-binding protein 5-B
, RNA-binding motif protein 5
, RNA-binding protein 5
, RNA-binding protein 5-like
, RNA-binding motif protein 5-A
, RNA-binding protein 5-A
, putative tumor suppressor LUCA15
, renal carcinoma antigen NY-REN-9
, G15 protein
, tumor suppressor LUCA15