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Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 and SRSF3 (show SRSF3 Proteins) in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA.
Report no correlation between expression of glucocorticoid receptor (show NR3C1 Proteins) isoforms and SRp30c.
Overexpression of SRSF9 and SRSF1 (show SRSF1 Proteins) promote beta-catenin (show CTNNB1 Proteins) accumulation via the recruitment of beta-catenin (show CTNNB1 Proteins) mRNA and by enhancing its translation in an mTOR (show FRAP1 Proteins)-dependent manner.
Relative levels of SRp20 (show SRSF3 Proteins), SRp30c, and SRp40 (show SRSF5 Proteins) in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness.
these data indicated that tumor suppressive miR-1 (show FSD1 Proteins) induces apoptosis through direct inhibition of SRSF9 in bladder cancer.
These results suggest that SRp30c can activate human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism: directly by stimulating splicing to late splice sites and indirectly by inhibiting competing early splice sites.
SRp30c can function as a repressor of 3' splice site utilization and suggest that the SRp30c-CE9 interaction may contribute to the control of hnRNP A1 (show HNRNPA1 Proteins) alternative splicing.
SRp30c protein is an interacting protein of YB-1 (show YBX1 Proteins)
Serine-arginine-rich protein (show MANF Proteins) p30 (show CENPV Proteins) directs alternative splicing of glucocorticoid receptor (show NR3C1 Proteins) pre-mRNA to glucocorticoid receptor (show NR3C1 Proteins) beta in neutrophils.
Results suggest that bombesin-induced expression of SRp30c affects gllucorticoid receptor (GR) pre-mRNA splicing, leading to increased GR beta expression and contributing to glucocorticoid resistance in PC cells.
cooperative action of multiple SR proteins in the regulation of GnRH (show GNRH1 Proteins) pre-mRNA splicing; SRp30c specifically binds to both ESE3 (show EHF Proteins) and ESE4
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene.
SR splicing factor 9
, pre-mRNA-splicing factor SRp30C
, splicing factor, arginine/serine-rich 9
, splicing factor, arginine/serine rich 9
, serine/arginine-rich splicing factor 9