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SMN1 Proteins

(Survival of Motor Neuron 1, Telomeric (SMN1))
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy\; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008].
SMN1 Protein (AA 49-140) (GST tag) SMN1 Protein (AA 49-140) (GST tag) SMN1 Protein (AA 49-140) (GST tag) (ABIN1320589)

SMN1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

SMN1 Protein (AA 1-140) (GST tag) SMN1 Protein (AA 1-140) (GST tag) SMN1 Protein (AA 1-140) (GST tag) (ABIN1320585)

SMN1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA

SMN1 Protein (AA 1-288) (His tag) SMN1 Protein (AA 1-288) (His tag) SMN1 Protein (AA 1-288) (His tag) (ABIN3134732)

Crystallography grade SMN1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys

SMN1 Proteins by Grade

Find SMN1 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

SMN1 Proteins by Origin

Find SMN1 Proteins for a variety of species such as anti-Human SMN1, anti-Cat SMN1, anti-Cow SMN1. The species listed below are among those available. Click on a link to go to the corresponding products.

SMN1 Proteins by Source

Here you will find SMN1 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

SMN1 Proteins by Protein Type

Here you can find SMN1 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

SMN1 Proteins by Application

Find SMN1 Proteins validated for a specific application such as ELISA, WB, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular SMN1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320589
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320585
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134732
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7416892
Quantity 100 μg
Datasheet Datasheet
Reactivity Dog
Source Yeast
Validations
Cat. No. ABIN1461410
Quantity 1 mg
Datasheet Datasheet
Reactivity Cow
Source Yeast
Validations
Cat. No. ABIN1460985
Quantity 1 mg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1475468
Quantity 1 mg
Datasheet Datasheet
Reactivity Cat
Source Yeast
Validations
Cat. No. ABIN1636281
Quantity 1 mg
Datasheet Datasheet
Reactivity Cynomolgus
Source Yeast
Validations
Cat. No. ABIN1631650
Quantity 1 mg
Datasheet Datasheet

Aliases for SMN1 Proteins

survival motor neuron protein (LOC461829) Proteins
survival of motor neuron 1, telomeric (Smn1) Proteins
survival of motor neuron 1, telomeric (SMN1) Proteins
survival motor neuron 1 (Smn1) Proteins
survival of motor neuron 2, centromeric (SMN2) Proteins
survival motor neuron protein-like (LOC100348318) Proteins
survival motor neuron (SMN) Proteins
survival motor neuron protein (LOC100713418) Proteins
survival motor neuron protein (LOC100065744) Proteins
survival motor neuron protein (LOC102176643) Proteins
survival of motor neuron 1, telomeric (smn1) Proteins
AI849087 Proteins
BCD541 Proteins
fa12d01 Proteins
GEMIN1 Proteins
Gemin1 Proteins
QtsA-10002 Proteins
SMA Proteins
SMA1 Proteins
SMA2 Proteins
SMA3 Proteins
SMA4 Proteins
SMA@ Proteins
Smn Proteins
SMN Proteins
smn Proteins
SMN1 Proteins
SMN2 Proteins
SMNT Proteins
T-BCD541 Proteins
TDRD16A Proteins
wu:fa12d01 Proteins
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