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Dog (Canine) Monoclonal SRPK2 Primary Antibody for IF, WB - ABIN968376
Wang, Lin, Dyck, Yeakley, Songyang, Cantley, Fu: SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. in The Journal of cell biology 1998
Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in splicesomal B complex formation via the phosphorylation of DDX23/PRP28.
SFRS protein kinase 2
, SR protein kinase 2
, SR-protein-specific kinase 2
, serine kinase SRPK2
, serine/arginine-rich protein-specific kinase 2
, serine/arginine-rich splicing factor kinase 2
, serine/threonine-protein kinase SRPK2
, SRSF protein kinase 2
, WW domain binding protein 6
, serine/arginine-rich protein specific kinase 2
, serine/threonine-protein kinase SRPK2-like