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anti-Human SRSF1 Antibodies:
anti-Mouse (Murine) SRSF1 Antibodies:
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Human Polyclonal SRSF1 Primary Antibody for ICC, IF - ABIN4353084
Brown, Dobrikov, Gromeier et al.: Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated ... in Journal of virology 2014
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Cow (Bovine) Polyclonal SRSF1 Primary Antibody for IHC, WB - ABIN2779013
Velazquez-Dones, Hagopian, Ma, Zhong, Zhou, Ghosh, Fu, Adams: Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. in The Journal of biological chemistry 2005
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We now show that the ability of SRPK1 (show SRPK1 Antibodies) to mobilize SRSF1 from speckles to the nucleoplasm is dependent on active CLK1 (show CDK11B Antibodies). Diffusion from speckles is promoted by the formation of an SRPK1 (show SRPK1 Antibodies)-CLK1 (show CDK11B Antibodies) complex that facilitates dissociation of SRSF1 from CLK1 (show CDK11B Antibodies) and enhances the phosphorylation of several serine-proline dipeptides in this SR protein (show RNPS1 Antibodies)
Authors showed that Mir505-3p was capable of inhibiting tumor proliferation driven by SRSF1 in two neural tumor cell lines, Neuro-2a (N2a) and U251, exclusively in serum-reduced condition. Authors observed that the protein level of SRSF1 was gradually promoted by increasing concentration of serum.
The present study suggested that the tumor suppressor miR30c may be involved in prostate cancer tumorigenesis, possibly via targeting ASF/SF2.
It has been proposed that SF2/ASF has a protective role against JC virus reactivation in multiple sclerosis patients.
Immune suppression of JC virus gene expression is mediated by SRSF1.
ASF/SF2 is identified as a splicing regulator (show PTBP2 Antibodies) of cyclin T1 (show CCNT1 Antibodies), which contributes to the control of the subsequent transcription events.
Findings suggest MALAT1 increases AKAP-9 (show AKAP9 Antibodies) expression by promoting SRPK1 (show SRPK1 Antibodies)-catalyzed SRSF1 phosphorylation in CRC (show CALR Antibodies) cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 (show AKAP9 Antibodies) expression in CRC (show CALR Antibodies) cells.
high level of SF2, as a novel oncoprotein in RCC (show XRCC1 Antibodies), was significantly associated with poor survival in a large cohort of RCC (show XRCC1 Antibodies) specimens. Taken together, our study presents a road map for the prediction and validation of miR (show MLXIP Antibodies)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (show XRCC1 Antibodies) progression.
The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.
We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 (show A2BP1 Antibodies) and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements
In addition, overexpression of SRSF1 in XRCC4 (show XRCC4 Antibodies)-deficient cells restored the normal level of apoptosis, suggesting that SRSF1 functions downstream of XRCC4 (show XRCC4 Antibodies) in activating CAD (show CAD Antibodies).
SRSF1 is a key regulator of DBF4B (show DBF4 Antibodies) pre-mRNA splicing dysregulation in colon cancer. SRSF1 is required for cancer cell proliferation.
LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin (show CTNNB1 Antibodies) and SRSF1.
This study showed that the splicing factor (show SLU7 Antibodies) kinase SRPK1 (show SRPK1 Antibodies) is a key regulator of spinal nociceptive processing in naive and nerve injured animals. We present evidence for a novel mechanism in which altered SRSF1 localization/function in neuropathic pain results in sensitization of spinal cord neurons.
The expression levels of three splicing factors, ESRP1 (show ESRP1 Antibodies), PTB (show PTBP1 Antibodies) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.
RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Deletion of RRM1 (show RRM1 Antibodies) eliminated the splicing activity of SRSF1 and thus cellular transformation.
Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (show SRSF2 Antibodies) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Treatment with IL-17 (show IL17A Antibodies) prolongs the half-life of chemokine (show CCL1 Antibodies) CXCL1 (show CXCL1 Antibodies) mRNA via the adaptor TRAF5 (show TRAF5 Antibodies) and the splicing-regulatory factor SF2 (ASF).
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
, SR splicing factor 1
, alternative-splicing factor 1
, pre-mRNA-splicing factor SF2, P33 subunit
, splicing factor 2
, splicing factor, arginine/serine-rich 1
, pre-mRNA-splicing factor SRp30a
, splicing factor, arginine/serine-rich 1 (ASF/SF2)
, splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
, splicing factor, arginine/serine-rich 1B
, splicing factor arginine/serine-rich 1
, serine/arginine-rich splicing factor 1B
, splicing factor, arginine/serine-rich 1b