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Human SRSF1 Protein expressed in Wheat germ - ABIN1319738
Aissat, de Becdelièvre, Golmard, Vasseur, Costa, Chaoui, Martin, Costes, Goossens, Girodon, Fanen, Hinzpeter: Combined computational-experimental analyses of CFTR exon strength uncover predictability of exon-skipping level. in Human mutation 2013
A -44 G to A "hot zone" putative functional noncoding variant of SRSF1 was found in an AML (show RUNX1 Proteins) patient. It alters the binding activities of E2F6 (show E2F6 Proteins), ELF1 (show EFNA2 Proteins), and ELK4 (show ELK4 Proteins), ELK4 (show ELK4 Proteins).
We now show that the ability of SRPK1 (show SRPK1 Proteins) to mobilize SRSF1 from speckles to the nucleoplasm is dependent on active CLK1 (show CDK11B Proteins). Diffusion from speckles is promoted by the formation of an SRPK1 (show SRPK1 Proteins)-CLK1 (show CDK11B Proteins) complex that facilitates dissociation of SRSF1 from CLK1 (show CDK11B Proteins) and enhances the phosphorylation of several serine-proline dipeptides in this SR protein (show RNPS1 Proteins)
Authors showed that Mir505-3p was capable of inhibiting tumor proliferation driven by SRSF1 in two neural tumor cell lines, Neuro-2a (N2a) and U251, exclusively in serum-reduced condition. Authors observed that the protein level of SRSF1 was gradually promoted by increasing concentration of serum.
The present study suggested that the tumor suppressor miR30c may be involved in prostate cancer tumorigenesis, possibly via targeting ASF/SF2.
It has been proposed that SF2/ASF has a protective role against JC virus reactivation in multiple sclerosis patients.
Immune suppression of JC virus gene expression is mediated by SRSF1.
ASF/SF2 is identified as a splicing regulator (show PTBP2 Proteins) of cyclin T1 (show CCNT1 Proteins), which contributes to the control of the subsequent transcription events.
Findings suggest MALAT1 increases AKAP-9 expression by promoting SRPK1 (show SRPK1 Proteins)-catalyzed SRSF1 phosphorylation in CRC (show CALR Proteins) cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 expression in CRC (show CALR Proteins) cells.
high level of SF2, as a novel oncoprotein in RCC (show XRCC1 Proteins), was significantly associated with poor survival in a large cohort of RCC (show XRCC1 Proteins) specimens. Taken together, our study presents a road map for the prediction and validation of miR (show MLXIP Proteins)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (show XRCC1 Proteins) progression.
The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.
In addition, overexpression of SRSF1 in XRCC4-deficient cells restored the normal level of apoptosis, suggesting that SRSF1 functions downstream of XRCC4 in activating CAD.
SRSF1 is a key regulator of DBF4B (show DBF4 Proteins) pre-mRNA splicing dysregulation in colon cancer. SRSF1 is required for cancer cell proliferation.
LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin (show CTNNB1 Proteins) and SRSF1.
This study showed that the splicing factor (show SLU7 Proteins) kinase SRPK1 (show SRPK1 Proteins) is a key regulator of spinal nociceptive processing in naive and nerve injured animals. We present evidence for a novel mechanism in which altered SRSF1 localization/function in neuropathic pain results in sensitization of spinal cord neurons.
The expression levels of three splicing factors, ESRP1 (show ESRP1 Proteins), PTB (show PTBP1 Proteins) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.
RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Deletion of RRM1 (show RRM1 Proteins) eliminated the splicing activity of SRSF1 and thus cellular transformation.
Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (show SRSF2 Proteins) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Treatment with IL-17 (show IL17A Proteins) prolongs the half-life of chemokine (show CCL1 Proteins) CXCL1 (show CXCL1 Proteins) mRNA via the adaptor TRAF5 (show TRAF5 Proteins) and the splicing-regulatory factor SF2 (ASF).
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
, SR splicing factor 1
, alternative-splicing factor 1
, pre-mRNA-splicing factor SF2, P33 subunit
, splicing factor 2
, splicing factor, arginine/serine-rich 1
, pre-mRNA-splicing factor SRp30a
, splicing factor, arginine/serine-rich 1 (ASF/SF2)
, splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
, splicing factor, arginine/serine-rich 1B
, splicing factor arginine/serine-rich 1
, serine/arginine-rich splicing factor 1B
, splicing factor, arginine/serine-rich 1b