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inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) is an intracellular target of the PPIA (show PPIA Proteins)-Sanglifehrin A binary complex.
The findings suggest that overexpressed IMPDH2 can be used as a biomarker for kidney and bladder cancer diagnosis and is a potential therapeutic target for the diseases
IMPDH2 is directly involved in the development of chemoresistance and radioresistance in osteosarcoma cells.
Compared with non-cancerous prostate tissues, IMPDH2 mRNA and protein expression levels were both significantly upregulated in prostate cancer tissues.
the localization of IMPDH2 inside the nucleus of human cells as well as the ultrastructure of R&R inclusions
Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Anti-IMPDH2 may cause difficulties in interpretation of immunofluorescence patterns in routine autoantibody testing.
IMPDHII plays an important role in the negative regulation of TLR2 signaling by modulating PI3K (show PIK3CA Proteins) activity.
in the absence of ligand the mobilities of "flap (show ALOX5AP Proteins)" and "loop" regions of IMPDH-II (1B3O) structures are mostly controlled by the four (W 1, W 2, W 3, and W 4) conserved water molecular centers and their dynamics
resequenced IMPDH1 and IMPDH2 using DNA from 288 individuals from three ethnic groups and performed functional genomic studies of the sequence variants observed; identfied 25 SNPs, 24 novel, in IMPDH2
IMPDH2 mediated guanine nucleotide synthesis is essential for normal development of the enteric nervous system and other neural crest derivatives.
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
IMP (inosine monophosphate) dehydrogenase 2
, inosine monophosphate dehydrogenase 2
, IMP (inosine 5'-monophosphate) dehydrogenase 2
, inosine-5'-monophosphate dehydrogenase 2-like
, IMP oxireductase 2
, IMPD 2
, IMPDH 2
, inosine 5' phosphate dehydrogenase 2
, inosine monophosphate dehydrogenase type II
, inosine-5'-monophosphate dehydrogenase 2
, IMP dehydrogenase 2
, inosine 5'-phosphate dehydrogenase 2
, inosine 5-monophosphate dehydrogenase 2
, IMP dehydrogenase type II