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anti-Human ABI1 Antibodies:
anti-Mouse (Murine) ABI1 Antibodies:
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Human Polyclonal ABI1 Primary Antibody for IHC - ABIN965496
Biesova, Piccoli, Wong: Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth. in Oncogene 1997
Show all 6 Pubmed References
Human Polyclonal ABI1 Primary Antibody for IF, WB - ABIN548494
Trinh-Trang-Tan, Bigot, Picot, Lecomte, Kordeli: AlphaII-spectrin participates in the surface expression of cell adhesion molecule L1 and neurite outgrowth. in Experimental cell research 2014
Show all 4 Pubmed References
Human Polyclonal ABI1 Primary Antibody for ICC, IF - ABIN252998
Chorzalska, Kim, Roder, Tepper, Ahsan, Rao, Olszewski, Yu, Terentyev, Morgan, Treaba, Zhao, Liang, Gruppuso, Dubielecka: Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia. in Stem cells and development 2017
Human Polyclonal ABI1 Primary Antibody for ICC, IHC (p) - ABIN3043678
Cui, Yu, Dong, Chen, Zhang, Liu: Downregulation of ABI1 expression affects the progression and prognosis of human gastric carcinoma. in Medical oncology (Northwood, London, England) 2010
our findings indicated that ABI1 contributes to the development and progression of hepatocellular carcinoma (HCC (show FAM126A Antibodies)) as an oncogene (show RAB1A Antibodies) and may serve as a valuable prognostic marker for HCC (show FAM126A Antibodies) patients.
these data indicate that HCV exploits host Abi1 protein via NS5A to modulate MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling pathway for its own propagation.
Suggest that Abi1 acts as a tumor-promoting gene in epithelial ovarian cancer progression, which may lead to unfavorable prognosis.
These results indicate that the alpha4-Abi-1 signaling pathway may mediate acquisition of the drug-resistant phenotype of leukemic cells.
Our data indicate that phosphorylated Abi1 contributes to the invasive properties of colorectal cancer.
Abi1 is expressed at the invasive front of colorectal carcinomas and localizes to the leading edge of lamellipodia in cultured colorectal carcinoma cells.
Data indicate that Abi1 is activated by the c-Abl (show ABL1 Antibodies)-Crk-associated substrate (CAS (show BCAR1 Antibodies)) pathway, and Abi1 reciprocally controls the activation of its upstream regulator c-Abl (show ABL1 Antibodies).
a possible role for Abi1 as a marker for early KRAS mutation in hyperplastic polyps
Breast tumors expressing high levels of Abi1 are significantly associated with early recurrence and worse survival on multivariate analysis.
Down-regulation of E3B1/ABI-1 expression in human carcinomas may play a critical role in tumor progression and in determining disease prognosis.
The expression of NESH/Abi-3 (show ABI3 Antibodies) caused degradation of endogenous Abi-1, which led to the formation of a NESH/Abi-3 (show ABI3 Antibodies)-based WAVE2 (show WASF2 Antibodies) complex.
CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis
sential role for Abi1 in embryonic survival and WAVE2 (show WASF2 Antibodies) complex integrity
Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
Abi1 (also known as E3b1) recruits PI3K, via p85 (show ECM1 Antibodies), into a multimolecular signaling complex that includes Eps8 (show EPS8 Antibodies) and Sos-1 (show SOS1 Antibodies)
Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins
Altogether these data identify a WAVE2 (show WASF2 Antibodies)-Abi1 complex crucial for the normal actin cytoskeleton reorganization and migration of macrophages in response to CSF-1 (show CSF1 Antibodies).
c-Abl (show ABL1 Antibodies) activates WAVE2 (show WASF2 Antibodies) via tyrosine phosphorylation to promote actin remodeling in vivo; Abi-1 forms the crucial link between these two factors
These results show that the interaction between Abi-1 and betaPIX (show ARHGEF7 Antibodies) is involved in the formation of growth factor-induced membrane dorsal ruffles.
NESH (Abi-3 (show ABI3 Antibodies)), like Abi-1 and Abi-2 (show ABI2 Antibodies), is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (show ABL1 Antibodies).
Abi1 scaffold protein is an essential regulator of cell movement processes required for normal eye development in Xenopus embryos and requires an Src homology 3 domain-dependent interaction with Wasp to regulate this complex morphogenetic process
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10\;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.
Abelson interactor 1
, Abl-interactor protein 1 long
, abl interactor 1
, abl-binding protein 4
, eps8 SH3 domain-binding protein
, interactor protein AblBP4
, nap1 binding protein
, spectrin SH3 domain-binding protein 1
, abelson interactor 1
, eps8 binding protein
, eps8-binding protein
, spectrin SH3 domain binding protein 1
, eps8 binding protein (e3B1), alternatively spliced
, abl-interactor 1
, Abl-interactor 1
, Abl interactor 1
, abl interactor 1-like
, LOW QUALITY PROTEIN: abl interactor 1