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we show that drebrin and hCDC14A regulate the recruitment of the actin organizer Arp2 to centrosomes. In addition, during ciliogenesis hCDC14A also regulates endocytosis and targeting of myosin Va vesicles to the basal body in a drebrin-independent manner, indicating that it impacts primary cilia formation in a multilayered manner.
Collectively, our results demonstrate that palladin can functionally replace the Arp2/3 complex during bacterial actin-based cellular entry and intracellular motility of Listeria monocytogenes.
RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway
We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects.
evidence of a direct protein-protein interaction between PKD2 and Arp2/3
miR-24-1*/let-7a*-ARP2/3 complex-RAC isoforms pathway may represent a novel pathogenic mechanism for Hirschsprung disease.
this study identified roles for ARP2 and filopodia in human respiratory syncytial virus -induced cell motility, virus production, and cell-to-cell spread.
Arp2 and Arp3 expression was increased under atherosclerotic conditions both in ApoE-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs).
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 in U251 human glioma cells.
Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.
demonstrate that the Arp2/3 complex in higher eukaryotes is actually a family of complexes with different properties
Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex.
Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
The loss of the Arp2/3 complex acts as a stress that initiates cell cycle arrest by triggering p16INK4a/p14Arf transcription.
Coronin3 can regulate gastric cancer (GC) invasion and metastasis through Arp2, and the combination of Coronin3 and Arp2 provides a potential marker for predicting GC prognosis.
study unveils an ARP2/3:VCA-independent function of nuclear-WASp in TH1 gene activation that is uncoupled from its cytoplasmic role in actin polymerization.
Cortactin has a role as a scaffold for Arp2/3 and WAVE2 at the epithelial zonula adherens
The Arp2/Arp3 complex has a role in osmotic signaling.
We demonstrate that WAVE2-Arp2/3 is a major nucleator of actin assembly at the zonula adherens and likely acts in response to junctional Rac signaling
Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions.
We find that the expression of the actin polymerization complex Arp2/3 is reduced in dysbindin-deficient cells, thus affecting actin-dependent phenotypes
Dendritic cells possess a mechanism to pass through micrometric constrictions. This mechanism is based on a rapid Arp2/3-dependent actin nucleation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear deformability.
Arp2/3 complex is an essential regulator of adipocyte development through control of the formation of cortical actin structures, which may facilitate nutrient uptake and signalling events.
WASH complex regulates Arp2/3 complex and is required for cytokinesis and polar body extrusion.
Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
The Arp2/3 complex may regulate mouse embryo development via its effect on cell division.
Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
Cells depleted of Arp2/3 complex cannot respond to a surface-bound gradient of extracellular matrix (haptotaxis).
Show that the Arp2/3 complex localizes to the oocyte cortical cap in a Ran-GTPase-dependent manner and nucleates actin filaments in the cortical cap and a cytoplasmic actin network.
Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration
N-WASP and the Arp2/3 complex trigger actin polymerization during a late step in clathrin-mediated endocytosis
Arp2/3 inhibition in growth cones doesn't affect actin organization or inhibit lamellipodia protrusion or filopodia formation. Arp2/3 inhibition enhances axon elongation and causes defects in growth cone guidance.
de novo actin polymerization process was functionally dependent on the kinase activity of Hck, WASp, the Arp2/3 complex, and Cdc42 but not Rac or Rho.
Data show that focal adhesion kinase (FAK) and the Arp2/3 complex associate and colocalize at transient structures formed early after cell adhesion.
Arp2-depleted fibroblasts exhibit severe defects in formation of sheet-like protrusions at early time points of cell spreading, with sheet-like protrusions limited to regions along the length of linear protrusions.
localises in filopodia and lamellipodia of spreading cells; doesn't depend on local adhesion or on microtubules for localisation
WASH complex activates Arp2/3-mediated actin nucleation and binds directly to liposomes. WASH also interacts with dynamin.
crystal structure of Arp2/3 complex
These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2/3 activation.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
interacts with contactin and N-WASp
conserved surface residues to search for functionally important structural elements
Data show that L. monocytogenes motility can be separated into an Arp2/3-dependent nucleation phase, and an Arp2/3-independent elongation phase which is dependent upon fascin.
crystal structures of Arp2/3 complex with bound ATP or ADP
WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament.
domain rearrangements of Arp2 and Arp3 result in a closed conformational state consistent with an "actin-dimer" model for the active state
Arp2/3 complex regulates mitochondrial-dependent Ca(2+) signaling in response to salt stress.Arp2 is required for mitochondrial distribution.
The work indicates that regulation of actin reassembly through ARP2/3 complex activity is crucial for stomatal regulation.
The rapid growth of roots in the light requires a functional ARP2/3-SCAR complex.
BRK1 is required for accumulation of SCAR1 protein in vivo, potentially explaining the apparently essential role of BRK1 in ARP2/3 complex function
Differences among SCARs in mRNA levels and the biochemical efficiency of ARP2/3 activation may explain the functional contributions of individual genes
ARP2/3 specifically enhances the movement of DNA breaks undergoing homology-directed repair.
The small GTPase Cdc42 promotes membrane protrusion during polar body emission via ARP2-nucleated actin polymerization.
The specific function of this gene has not yet been determined\; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.
actin-like protein 2
, actin-related protein 2
, ARP2 actin-related protein 2 homolog
, actin-like protein ACTL
, actin-like protein 2-A
, actin-related protein 2-A
, ARP2 actin-related protein 2 homolog (yeast)
, Actin-related protein 2
, actin-related protein 2-like
, actin-related protein Arp2
, ARP2 actin-related protein 2
, actin-like protein 2-B
, actin-related protein 2-B