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Human Monoclonal ACTR3 Primary Antibody for IF, IHC (p) - ABIN564363
Morel, Parton, Gruenberg: Annexin A2-dependent polymerization of actin mediates endosome biogenesis. in Developmental cell 2009
Show all 2 Pubmed References
Collectively, our results demonstrate that palladin can functionally replace the Arp2/3 complex during bacterial actin-based cellular entry and intracellular motility of Listeria monocytogenes.
we conclude that ARP3 may be a potential prognostic indicator and therapeutic target for hepatocellular carcinoma
RARalpha regulates Arp2/3-mediated actin cytoskeletal dynamics through a non-genomic signaling pathway
evidence of a direct protein-protein interaction between PKD2 and Arp2/3
miR-24-1*/let-7a*-ARP2/3 complex-RAC isoforms pathway may represent a novel pathogenic mechanism for Hirschsprung disease.
Authors found that ARP3 and profilin1 were 2 binding partners of LMO2, primarily in cytoplasm. LMO2. LMO2 mediated the assembly of a complex including ARP3, profilin1, and actin monomer, increased actin monomer binding to profilin1, and promoted lamellipodia/filopodia formation in basal-type breast cancer cells.
Arp2 and Arp3 expression was increased under atherosclerotic conditions both in ApoE-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs).
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 in U251 human glioma cells.
Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.
demonstrate that the Arp2/3 complex in higher eukaryotes is actually a family of complexes with different properties
Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex.
Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
The loss of the Arp2/3 complex acts as a stress that initiates cell cycle arrest by triggering p16INK4a/p14Arf transcription.
study unveils an ARP2/3:VCA-independent function of nuclear-WASp in TH1 gene activation that is uncoupled from its cytoplasmic role in actin polymerization.
Cortactin has a role as a scaffold for Arp2/3 and WAVE2 at the epithelial zonula adherens
The Arp2/Arp3 complex has a role in osmotic signaling.
Study suggested that positive CFL1 and Arp3 expression are closely related to tumor progression, metastasis, and poor prognosis of gallbladder cancer.
We demonstrate that WAVE2-Arp2/3 is a major nucleator of actin assembly at the zonula adherens and likely acts in response to junctional Rac signaling
Anthrax edema toxin induced transendothelial cell tunnels are resealed by MIM via Arp2/3-driven actin polymerization.
the centrosome transiently recruits Arp2/3 to perform processes such as centrosome separation prior to mitotic entry.
We find that the expression of the actin polymerization complex Arp2/3 is reduced in dysbindin-deficient cells, thus affecting actin-dependent phenotypes
possess a mechanism to pass through micrometric constrictions. This mechanism is based on a rapid Arp2/3-dependent actin nucleation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear deformability.
Arp2/3 complex is an essential regulator of adipocyte development through control of the formation of cortical actin structures, which may facilitate nutrient uptake and signalling events.
WASH complex regulates Arp2/3 complex and is required for cytokinesis and polar body extrusion.
Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
The Arp2/3 complex may regulate mouse embryo development via its effect on cell division.
Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
The results of this study pointed to the dysfunction of actin signaling, specifically that which converges to regulate Arp2/3, as an important cellular pathway that may contribute to the etiology of complex psychiatric disorders.
Cells depleted of Arp2/3 complex cannot respond to a surface-bound gradient of extracellular matrix (haptotaxis).
Show that the Arp2/3 complex localizes to the oocyte cortical cap in a Ran-GTPase-dependent manner and nucleates actin filaments in the cortical cap and a cytoplasmic actin network.
Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration
N-WASP and the Arp2/3 complex trigger actin polymerization during a late step in clathrin-mediated endocytosis
de novo actin polymerization process was functionally dependent on the kinase activity of Hck, WASp, the Arp2/3 complex, and Cdc42 but not Rac or Rho.
Data show that focal adhesion kinase (FAK) and the Arp2/3 complex associate and colocalize at transient structures formed early after cell adhesion.
The recessive embryonic lethal phenotype indicates that Arp3 plays a vital role for early mouse development, possibly when trophoblast cells become critical for implantation.
localises in filopodia and lamellipodia of spreading cells; doesn't depend on local adhesion or on microtubules for localisation
WASH complex activates Arp2/3-mediated actin nucleation and binds directly to liposomes. WASH also interacts with dynamin.
crystal structure of Arp2/3 complex
These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2/3 activation.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
interacts with contactin and N-WASp
conserved surface residues to search for functionally important structural elements
Data show that L. monocytogenes motility can be separated into an Arp2/3-dependent nucleation phase, and an Arp2/3-independent elongation phase which is dependent upon fascin.
crystal structures of Arp2/3 complex with bound ATP or ADP
WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament.
domain rearrangements of Arp2 and Arp3 result in a closed conformational state consistent with an "actin-dimer" model for the active state
ARP2/3 specifically enhances the movement of DNA breaks undergoing homology-directed repair.
The specific function of this gene has not yet been determined\; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene.
actin-like protein 3
, actin-related protein 3
, ARP3 actin-related protein 3 homolog
, actin-related protein 3 homolog (yest)
, Actin-like protein 3
, actin-like protein
, ARP3 (actin-related protein 3, yeast) homolog
, ARP3 actin-related protein 3 homolog (yeast)