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Full name:: BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit Proteins (BRK1)

On www.antibodies-online.com are 7 BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit (BRK1) Proteins from 4 different suppliers available. Additionally we are shipping BRK1 Antibodies (30) and BRK1 Kits (4) and many more products for this protein. A total of 43 BRK1 products are currently listed.

Synonyms:: 6720456B07Rik, ATBRK1, AW011779, BRICK1, brk1, C3orf10, C22H3orf10, hHBrk1, HSPC300, MDS027, T9I22.8, T9I22_8

list all proteins	Gene Name	GeneID	UniProt
Rat BRK1	BRK1	679934
	BRK1	55845	Q8WUW1
	BRK1	101314	Q91VR8
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Relevant Pathways for BRK1 Proteins

RTK Signaling

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More Proteins for BRK1 Interaction Partners

Human BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit (BRK1) interaction partners

Sp1 (show PSG1 Proteins) transcriptionally regulates BRK1 expression in non-small cell lung cancer cells.
We verified that NRF-1 (show NFE2L1 Proteins) positively regulates FAM134C and ENOX1 (show ENOX1 Proteins), and negatively regulates C3orf10 in human neuroblastoma (show ARHGEF16 Proteins) IMR-32 cells and primary rat cortical neurons.
Data show that Brk1 downregulation results in defective directional migration and invasive growth in renal cell carcinoma cells as well as in other tumor cell types.
Von Hippel-Lindau (VHL) locus deletion of the HSPC300 actin regulator gene greatly lowers risk of clear cell renal cell carcinoma (show MOK Proteins) development in Spanish VHL (show VHL Proteins) syndrome patients studied.
Growing body of evidence suggesting that patients with VHL syndrome caused by large VHL deletions that include C3orf10 may be designated as having a specific subtype (Type 1B) of the disorder.

Mouse (Murine) BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit (BRK1) interaction partners

Data show that genetic ablation of Brk1 results in dramatic defects in embryo compaction and development, suggesting an essential role for this protein in actin dynamics.

Arabidopsis thaliana BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit (BRK1) interaction partners

BRK1 is required for accumulation of SCAR1 (show WASF1 Proteins) protein in vivo, potentially explaining the apparently essential role of BRK1 in ARP2 (show ACTR2 Proteins)/3 complex function
member of the "distorted group" of trichome morphology mutants and a critical WAVE-complex subunit that selectively stabilizes the Arp2 (show ACTR2 Proteins)/3 activator SCAR2

BRK1 Protein Profile

Protein Summary

Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).

Alternative names and synonyms associated with BRK1

BRICK1, SCAR/WAVE actin-nucleating complex subunit (brk1)
BRICK1, SCAR/WAVE actin nucleating complex subunit (BRK1)
BRICK1, SCAR/WAVE actin-nucleating complex subunit (Brk1)
BRICK1, SCAR/WAVE actin nucleating complex subunit (brk1)
brick 1 (brk1)
BRICK1, SCAR/WAVE actin-nucleating complex subunit S homeolog (brk1.S)
BRICK1 (BRK1)

6720456B07Rik protein
ATBRK1 protein
AW011779 protein
BRICK1 protein
brk1 protein
C3orf10 protein
C22H3orf10 protein
hHBrk1 protein
HSPC300 protein
MDS027 protein
T9I22.8 protein
T9I22_8 protein

Protein level used designations for BRK1

probable protein BRICK1 , probable protein brick1 , GRMZM5G842058 , protein BRICK1 , probable protein BRICK1-B , BRICK1, SCAR/WAVE actin-nucleating complex subunit, homolog , haematopoietic stem/progenitor cell protein 300

GENE ID	SPECIES
415187	Danio rerio
540092	Bos taurus
679934	Rattus norvegicus
100528356	Ictalurus punctatus
542086	Zea mays
100037105	Xenopus laevis
55845	Homo sapiens
101314	Mus musculus
816795	Arabidopsis thaliana

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