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Human EPGN ELISA Kit for Sandwich ELISA - ABIN1117922
Zhu, Kang, Rosmorduc, Evans, Santoro, Ross, Gane, Vogel, Jeffers, Meinhardt, Peña: Biomarker Analyses of Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib with or without Erlotinib in the SEARCH Trial. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
Study shows how the EGFR (show EGFR ELISA Kits) ligands epiregulin (EREG (show EREG ELISA Kits)) and epigen (EPGN) stabilize different dimeric conformations of the EGFR (show EGFR ELISA Kits) extracellular region. Results reveal how responses to different EGFR (show EGFR ELISA Kits) ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (show RET ELISA Kits) (RTK) signaling specificity.
EPG is an EGF (show EGF ELISA Kits)-like growth factor and a low affinity ligand
activation of the EGFR (show EGFR ELISA Kits) by its ligand epigen during early epidermal development causes hyperplasia of the sebaceous gland and, to a minor extent, hyperplasia of the interfollicular epidermis and increased hair follicles density.
Epigen has non-essential functions or functions that can be compensated by other EGFR (show EGFR ELISA Kits) ligands during growth and tissue homeostasis.
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants.
, epithelial mitogen homolog