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anti-Human EPH Receptor A4 Antibodies:
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Human Monoclonal EPH Receptor A4 Primary Antibody for ELISA, WB - ABIN1724712
Walkenhorst, Dütting, Handwerker, Huai, Tanaka, Drescher: The EphA4 receptor tyrosine kinase is necessary for the guidance of nasal retinal ganglion cell axons in vitro. in Molecular and cellular neurosciences 2001
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Human Polyclonal EPH Receptor A4 Primary Antibody for IHC (p) - ABIN2473463
Theil, Frain, Gilardi-Hebenstreit, Flenniken, Charnay, Wilkinson: Segmental expression of the EphA4 (Sek-1) receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20. in Development (Cambridge, England) 1998
Show all 3 Pubmed References
Human Polyclonal EPH Receptor A4 Primary Antibody for IHC (p), WB - ABIN391890
Prevost, Woulfe, Tanaka, Brass: Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. in Proceedings of the National Academy of Sciences of the United States of America 2002
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These findings confirmed that EphA4 is a direct target gene of miR (show MLXIP Antibodies)-335 and that miR (show MLXIP Antibodies)-335 suppresses breast cancer cell proliferation and motility in part by directly inhibiting EphA4 expression.
Therefore EphA4 is an emerging AbetaOs receptor and the activation of the EphA4/c-Abl axis would explain the synaptic spine alterations found in Alzheimer's disease.
High erythropoietin (show EPO Antibodies)-producing hepatocellular carcinoma receptor A (EphA) 1 (show EPHA1 Antibodies), 2, and 4 expression levels were significantly related to recurrence.
These results demonstrate a novel role for SORLA (show SORL1 Antibodies) as a physiological and pathological EphA4 modulator.
The expression of both EphA4-FL and EphA4-N was significantly higher in the nervous tissue of SOD1 (show SOD1 Antibodies)(G93A) compared to wild-type mice suggesting that both forms are modulated during the disease process.
the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies), Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathways as well as ERK1/2 downstream of EPHA4 receptor activation, play an important role in the regulation of events related with the EMT (show ITK Antibodies) development, which may be associated with the therapeutic failure in rectal cancer after radiotherapy.
Molecular interactions of EphA4, growth hormone receptor (show GHR Antibodies), Jak2 (show JAK2 Antibodies), and STAT5B (show STAT5B Antibodies) have been described.
Findings demonstrated that mutant alpha2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth, while cervical spinal neurons use only ephrin forward signaling
Reduced EphA4 expression is associated with EBV-associated B lymphoma.
No difference was found in the expression of EPHA4 in morphologically normal glands, HGPIN, or prostatic cancer.
Results suggest a circadian role for EphA4 in the SCN (show SRI Antibodies) neuronal network, affecting the circadian system and contributing to the circadian response to light.
ephrin-B2 (show EFNB2 Antibodies) and EphA4 have graded and modular expression patterns in the developing inferior colliculus
findings suggest a role for EphA4 in shaping cortical oscillations during sleep that is independent from sleep need
The present study demonstrates that EphA4 and EphA7 (show EPHA7 Antibodies) receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group.
These results suggest that EphA4, a novel and promising target for treatment, exacerbates EBI (show TBL1X Antibodies) through an Ephexin-1 (show NGEF Antibodies)/ROCK2 (show ROCK2 Antibodies) pathway after subarachnoid hemorrhage.
Our studies show that forward signaling through the EphA4 tyrosine kinase receptor (show KDR Antibodies), mediated by ephrins expressed by subpopulations of neuroblasts and astrocytes, is required for compact, directional organization of neuroblasts and astrocytes within the pathway and efficient transit of neuroblasts through the anterior forebrain to the olfactory bulb.
Findings suggest a putative novel mechanism for desipramine to modulate long-term potentiation through the regulation of the ephrinA3/EphA4 signaling pathway
expression of Eph (show EPHA1 Antibodies) A1, A2, A4, and A7 was strongly detected in endometrial epithelial cells during early pregnancy.
The EphA4 gene is significantly associated with litter size in pigs.
EphA4-dependent Brachyury (show TBX1 Antibodies) expression is required for dorsal mesoderm involution in the Xenopus gastrula.
show that EphA4 and its putative ligand, ephrin-A1 (show EFNA1 Antibodies) are expressed in a complementary manner in the involuting mesodermal and non-involuting ectodermal layers of early gastrulae, respectively
In myelinating co-cultures and in zebrafish, we find that the number of mature oligodendrocytes does not change as result of manipulating signaling through the ephrinA1-EphA4 (show EPHA3 Antibodies) system. However, in both systems, inhibition of EphA4 (show EPHA3 Antibodies) signaling leads to a higher number of myelin sheaths formed by each oligodendrocyte. In isolated oligodendrocyte cultures, activation of EphA4 (show EPHA3 Antibodies) reduced process extension.
Downregulation of EphA4a compromises actomyosin cables and cells with different rhombomeric identity intermingle, and the phenotype is rescued enhancing myosin II activity.
EphA4 (show EPHA3 Antibodies) is required for cell adhesion and rhombomere-boundary formation in the zebrafish.
Data show that EfnB2a (show EFNB2 Antibodies) is required in developing hindbrain for normal cell affinity and that EphA4 (show EPHA3 Antibodies) and EfnB2a (show EFNB2 Antibodies) regulate cell affinity independently within their respective rhombomeres.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.
, EPH-like kinase 8
, TYRO1 protein tyrosine kinase
, ephrin type-A receptor 4
, receptor protein-tyrosine kinase HEK8
, tyrosine-protein kinase TYRO1
, tyrosine-protein kinase receptor SEK
, ephrin receptor epsilon
, EPH receptor A4
, ephrin receptor EphA4
, ephrin receptor EphA4-like
, ephrin type-A receptor 4-like
, tyrosine-protein kinase receptor MPK-3
, tyrosine-protein kinase receptor SEK-1
, ephrin type-A receptor 4-B
, receptor tyrosine kinase
, tyrosine-protein kinase receptor PAG
, eph receptor A3
, eph-like kinase 2
, eph-like receptor tyrosine kinase 1
, ephrin type-A receptor 4a
, tyrosine-protein kinase receptor ZEK2