-
Results suggest a circadian role for EphA4 in the SCN neuronal network, affecting the circadian system and contributing to the circadian response to light.
-
ephrin-B2 and EphA4 have graded and modular expression patterns in the developing inferior colliculus
-
These results demonstrate a novel role for SORLA as a physiological and pathological EphA4 modulator.
-
findings suggest a role for EphA4 in shaping cortical oscillations during sleep that is independent from sleep need
-
The expression of both EphA4-FL and EphA4-N was significantly higher in the nervous tissue of SOD1(G93A) compared to wild-type mice suggesting that both forms are modulated during the disease process.
-
Findings demonstrated that mutant alpha2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth, while cervical spinal neurons use only ephrin forward signaling
-
The present study demonstrates that EphA4 and EphA7 receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group.
-
These results suggest that EphA4, a novel and promising target for treatment, exacerbates EBI through an Ephexin-1/ROCK2 pathway after subarachnoid hemorrhage.
-
Our studies show that forward signaling through the EphA4 tyrosine kinase receptor, mediated by ephrins expressed by subpopulations of neuroblasts and astrocytes, is required for compact, directional organization of neuroblasts and astrocytes within the pathway and efficient transit of neuroblasts through the anterior forebrain to the olfactory bulb.
-
Findings suggest a putative novel mechanism for desipramine to modulate long-term potentiation through the regulation of the ephrinA3/EphA4 signaling pathway
-
Delineation of the specific mutation in EphA4 in this strain is important for further functional studies, such as protein-protein interactions, immunostaining and gene compensatory studies, investigating the mechanism underlying the effects of altered function of Eph family of receptor tyrosine kinases on phenotype.
-
the results of the present study demonstrated that angiogenesis occurs, and that the molecules EphA4 and ephrin-A5 are expressed in the hippocampal CA1 and CA3 areas throughout epileptogenesis. PECAM-1 may detect epileptic microvessel patterns in the hippocampi of mice and EphA4 may contribute to the microvessel plasticity via the ephrin-A5 signaling pathway.
-
results suggest that EphA4 is involved in circadian sleep regulation
-
The findings of this study revealed the behavioral and circuit-level impact of conditional EphA4 mutation in a transcriptionally defined spinal interneuron subpopulation.
-
Data show the effects of genetic loss of ephrin-A5, Eph receptors EphA4, and EphA7 on the development of medulloblastoma tumors in the smoothened (Smo) transgenic mouse model.
-
EphA4 mediates long-term contextual fear conditioning memory formation in a kinase-independent manner.
-
with an fibroblast growth factor signal, contributes to maintenance of radial glial cells self-renewal and repression of differentiation through neuronal lineage
-
Study show that EphA4 is a substrate for PTP-oc in osteoclasts and that the molecular mechanism contributing to the PTP-oc-induced up-regulation of the osteoclast activity in part involves its dephosphorylation and inactivation of the EphA4 signaling.
-
These findings suggest that the ternary complex of EphA, FGFR and FRS2alpha formed by ligand stimulation regulates self-renewal and differentiation of mouse embryonic neural stem/progenitor cells
-
alpha-cell-specific EphA4(-/-) mice exhibit abnormal glucagon dynamics, and EphA4(-/-) alpha-cells contain less dense F-actin networks than EphA4(+/+) alpha-cells.