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Mouse (Murine) Polyclonal EPH Receptor B3 Primary Antibody for CyTOF, FACS - ABIN4900178
Feng, Sakamoto, Wu, Liu, Wiese, Green, Green, Akyol, Roy, Zhai, Cho, Fearon: Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. in PLoS genetics 2015
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Human Monoclonal EPH Receptor B3 Primary Antibody for IHC (p), ELISA - ABIN560764
Schauer, Janssen, Rimkus, Raggi, Feith, Friess, Theisen: Microarray-based response prediction in esophageal adenocarcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2010
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Human Monoclonal EPH Receptor B3 Primary Antibody for IHC, ELISA - ABIN969106
Bergemann, Zhang, Chiang, Brambilla, Klein, Flanagan: Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. in Oncogene 1998
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Human Monoclonal EPH Receptor B3 Primary Antibody for IP, ELISA - ABIN560768
Dubois, Leroy, Simon, Benistant, Roche: YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells. in American journal of cancer research 2015
Study found up-regulated expression of ephrinB3/EphB3 in intractable temporal lobe epilepsy patients and experimental temporal lobe epilepsy rats, which suggested that ephrinB3/EphB3 might be involved in the pathogenesis of temporal lobe epilepsy
work suggested that EphB3 acted as a tumor promoter in Papillary Thyroid Cancer by increasing the in vitro migration as well as the in vivo metastasis of Papillary Thyroid Cancer cells through regulating the activities of Vav2 (show VAV2 Antibodies) and Rho GTPases in a kinase-dependent manner.
These results show that EphB3 protein is lost in ovarian serous carcinoma and is associated with tumor grade and FIGO stage, which indicate that EphB3 protein may play a role in carcinogenesis of ovarian serous carcinoma and may be used as a molecular marker for prognosis.
results identify EPHB3 as a novel target of SNAIL1 (show SNAI1 Antibodies) and suggest that disabling EPHB3 signaling is an important aspect to eliminate a roadblock at the onset of EMT (show ITK Antibodies) processes.
These results uncover enhancer decommissioning as a mechanism for transcriptional silencing of the EPHB3 tumor suppressor.
EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A (show PPP2R4 Antibodies)/RACK1 (show GNB2L1 Antibodies)/Akt (show AKT1 Antibodies) signalling complex
Our work shows that EphB3 is consistently expressed by malignant T lymphocytes, most frequently in combination with EphB6 (show EPHB6 Antibodies), and that stimulation with their common ligands strongly suppresses Fas (show FAS Antibodies)-induced apoptosis in these cells.
Data show that EphB receptors interact with E-cadherin (show CDH1 Antibodies) and with the metalloproteinase ADAM10 (show ADAM10 Antibodies) at sites of adhesion.
EphB3 provides critical support to the development and progression of NSCLC by stimulating cell growth, migration, and survival.
Ephrin B3 (show EFNB3 Antibodies) receptor regulates the synthesis and release of D-serine in astrocytes, which may have important implications on synaptic transmission and plasticity.
although both EphB2 (show EPHB2 Antibodies) and EphB3 are necessary for cortical thymic epithelial maturation, the relevance of EphB3 is greater since EphB3-/- thymic cortex exhibits a more severe phenotype than that of EphB2 (show EPHB2 Antibodies)-deficient thymuses
that EphB3 signaling plays a deleterious role in synaptic stability and plasticity after traumatic brain injury
Ephrin-B3 (show EFNB3 Antibodies) expression is localized to the lateral cortex extramodular zones in the developing inferior colliculus
Mule also regulates protein levels of the receptor tyrosine kinase (show ERBB3 Antibodies) EphB3 by targeting it for proteasomal and lysosomal degradation.
A novel dependence receptor role of EphB3 in oligodendrocyte cell death after spinal cord injury.
These results suggest a major function for forward signaling through EphB2 (show EPHB2 Antibodies) and, to a lesser extent, EphB3, in either colonizing progenitor cells or thymic stromal cells.
Conclude that EphB3 mediates cell death in the adult cortex through a novel dependence receptor-mediated cell death mechanism in the injured adult cortex and is attenuated following ephrinB3 stimulation.
EphB2 (show EPHB2 Antibodies) and EphB3 are involved in the control of thymic epithelial cells (TEC (show NR4A3 Antibodies)) survival and that the absence of these molecules causes increased apoptotic TEC (show NR4A3 Antibodies).
EphB2 (show EPHB2 Antibodies) and EphB3 reverse signaling are critical for the normal development of the projection from the ventral cochlear nucleus to the contralateral medial nucleus of the trapezoid body.
EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A (show PPP2R2B Antibodies)/RACK1 (show GNB2L1 Antibodies)/Akt (show AKT1 Antibodies) signalling complex
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members.
ephrin receptor EphB3
, EPH receptor B3
, ephrin receptor EphB3-like
, ephrin type-B receptor 3-like
, EPH-like kinase 2
, EPH-like tyrosine kinase 2
, EPH-like tyrosine kinase-2
, embryonic kinase 2
, ephrin type-B receptor 3
, human embryo kinase 2
, tyrosine-protein kinase TYRO6
, developmental kinase 5
, tyrosine-protein kinase receptor SEK-4
, EPH-like kinase 10
, eph-like kinase 3
, eph-like receptor tyrosine kinase 3
, tyrosine-protein kinase receptor ZEK3
, tyrosine-protein kinase receptor TCK