Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human FGF19 Protein expressed in Escherichia coli (E. coli) - ABIN935365
Borello, Cobos, Long, McWhirter, Murre, Rubenstein: FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. in Neural development 2008
Human FGF19 Protein expressed in Wheat germ - ABIN1354010
Uchiyama, Naito, Takagi, Mizushima, Hayashi, Handa, Ishikawa, Yagi, Kokura, Yoshikawa: FGF19 protects colonic epithelial cells against hydrogen peroxide. in Digestion 2011
Human FGF19 Protein expressed in Escherichia coli (E. coli) - ABIN413241
Becker-Pauly, Barré, Schilling, Auf dem Keller, Ohler, Broder, Schütte, Kappelhoff, Stöcker, Overall: Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. in Molecular & cellular proteomics : MCP 2011
These data identify hypothalamic Fgf15 as a regulator of glucagon (show GCG Proteins) secretion.
Fgf15 is the sonic hedgehog (show SHH Proteins) downstream signal to control thalamic regionalization, neurogenesis, and neuronal differentiation by regulating the expression and mutual segregation of neurogenic and proneural regulatory genes.
human microbiota was able to reduce the levels of tauro-beta-muricholic acid and induce expression of FXR (show NR1H4 Proteins) target genes Fgf15 and Shp (show LAMC1 Proteins) in ileum after long-term colonization. We show that a human microbiota can change BA composition and induce FXR (show NR1H4 Proteins) signaling in colonized mice, but the levels of secondary BAs produced are lower than in mice colonized with a mouse microbiota
This study demonstrates that the FGF19-SHP (show LAMC1 Proteins)-LSD1 (show KDM1A Proteins) axis maintains homeostasis by suppressing unnecessary autophagic breakdown of cellular components, including lipids, under nutrient-rich postprandial conditions.
The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.
This study reveals SHP (show LAMC1 Proteins) as a global transcriptional partner of SREBP-2 (show SREBF2 Proteins) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19.
Protective effects of farnesoid X receptor (show xpr1 Proteins) on hepatic lipid accumulation are mediated by hepatic FXR (show NR1H4 Proteins) and are independent of intestinal FGF15 signaling.
Intestinal PPARalpha (show PPARA Proteins)-UDP- Glucuronyltransferases and downstream FXR (show NR1H4 Proteins)-FGF15 signalling play vital roles in control of bile acid homeostasis and the pathological development of colitis.
a direct role of intestinal FGF15/19 in the regulation of SI P450 (show POR Proteins) expression and may have profound implications for the prediction of drug exposure in patients with compromised hepatic P450 (show POR Proteins) function
findings implicate the brain in the antidiabetic action of systemic FGF19 and establish the brain's capacity to rapidly, potently, and selectively increase insulin (show INS Proteins)-independent glucose disposal
FGFR4 (show FGFR4 Proteins)/FGF19 autocrine signaling mediates the survival of a subset of basal-like breast cancer cells
FGF19 copy number may increase in hepatocellular carcinoma accompanying a complete response to sorafenib treatment
Study demonstrates that elevated FGF19 expression or hyperactivation of FGF19/FGFR4 (show FGFR4 Proteins) signaling in hepatocellular carcinoma cells is one of the main mechanisms of sorafenib resistance.
This is the first study to elucidate FGF19/FGFR4 (show FGFR4 Proteins) signaling in favor of hepatocellular carcinoma cells developing from fatty liver
High expression of FGF19 is associated with hepatocellular carcinoma.
Findings show that FGF19 provides a cytoprotective role against ER stress by activating a FGFR4 (show FGFR4 Proteins)-GSK3beta-Nrf2 (show GABPA Proteins) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (show FAM126A Proteins)) management.
Fibroblast growth factor 19 levels in human portal blood are higher than in arterial blood. Fibroblast growth factor 19 is released by the portal-drained viscera under fasted steady state conditions.
serum FGF19 and FGF21 and hepatic Klotho expression are inversely associated with hepatic damage in children with NAFLD
Administering FGF19, or suitable mimetic, as a pharmacological intervention to increase circulating levels of FGF19 and suppress BA synthesis by inhibiting CYP7A1 (show CYP7A1 Proteins) gene expression is likely to provide therapeutic benefits for many PBC (show DLAT Proteins) patients
Amplification of FGF19 was validated in independent LSCC samples. Furthermore, FGF19 stimulated LSCC cell growth in vitro. These data implicate FGF19 as a potential driver gene in LSCC with clinic characteristics as smoking.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
fibroblast growth factor 19
, fibroblast growth factor 15