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Human FGF19 Protein expressed in Wheat germ - ABIN1354010
Uchiyama, Naito, Takagi, Mizushima, Hayashi, Handa, Ishikawa, Yagi, Kokura, Yoshikawa: FGF19 protects colonic epithelial cells against hydrogen peroxide. in Digestion 2011
Human FGF19 Protein expressed in Escherichia coli (E. coli) - ABIN935365
Borello, Cobos, Long, McWhirter, Murre, Rubenstein: FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. in Neural development 2008
Human FGF19 Protein expressed in Escherichia coli (E. coli) - ABIN413241
Becker-Pauly, Barré, Schilling, Auf dem Keller, Ohler, Broder, Schütte, Kappelhoff, Stöcker, Overall: Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. in Molecular & cellular proteomics : MCP 2011
Study showed that FGF19 amplification is a genetic event in Chinese lung squamous cell carcinoma (LSCC) patients, with a frequency of 37.5%. FGF19 amplified LSCC cells express relatively higher levels of FGF19 mRNA expression, and downregulation of FGF19 expression can induce significant cell killing effects in vitro and in vivo.
FGFR4 (show FGFR4 Proteins)/FGF19 autocrine signaling mediates the survival of a subset of basal-like breast cancer cells
FGF19 copy number may increase in hepatocellular carcinoma accompanying a complete response to sorafenib treatment
Study demonstrates that elevated FGF19 expression or hyperactivation of FGF19/FGFR4 (show FGFR4 Proteins) signaling in hepatocellular carcinoma cells is one of the main mechanisms of sorafenib resistance.
This is the first study to elucidate FGF19/FGFR4 (show FGFR4 Proteins) signaling in favor of hepatocellular carcinoma cells developing from fatty liver
High expression of FGF19 is associated with hepatocellular carcinoma.
Findings show that FGF19 provides a cytoprotective role against ER stress by activating a FGFR4 (show FGFR4 Proteins)-GSK3beta-Nrf2 (show GABPA Proteins) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (show FAM126A Proteins)) management.
Fibroblast growth factor 19 levels in human portal blood are higher than in arterial blood. Fibroblast growth factor 19 is released by the portal-drained viscera under fasted steady state conditions.
serum FGF19 and FGF21 and hepatic Klotho expression are inversely associated with hepatic damage in children with NAFLD
Administering FGF19, or suitable mimetic, as a pharmacological intervention to increase circulating levels of FGF19 and suppress BA synthesis by inhibiting CYP7A1 (show CYP7A1 Proteins) gene expression is likely to provide therapeutic benefits for many PBC (show DLAT Proteins) patients
Fgf19 signaling is critical for embryonic forebrain development through its interaction with hedgehog (show SHH Proteins).
This study reveals an important role for FOXC1 (show FOXC1 Proteins) in the direct regulation of the FGF19-FGFR4 (show FGFR4 Proteins)-MAPK (show MAPK1 Proteins) pathway to promote both the development and maintenance of anterior segment structures within the eye.
Fgf19 is required for zebrafish lens and retina development.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
, fibroblast growth factor 19
, fibroblast growth factor 15