Browse our FGF19 Proteins (FGF19)

Human Fibroblast Growth Factor 19 (FGF19) interaction partners

1. Study showed that FGF19 amplification is a genetic event in Chinese lung squamous cell carcinoma (LSCC) patients, with a frequency of 37.5%. FGF19 amplified LSCC cells express relatively higher levels of FGF19 mRNA expression, and downregulation of FGF19 expression can induce significant cell killing effects in vitro and in vivo.

2. FGFR4 (show FGFR4 Proteins)/FGF19 autocrine signaling mediates the survival of a subset of basal-like breast cancer cells

3. FGF19 copy number may increase in hepatocellular carcinoma accompanying a complete response to sorafenib treatment

4. Study demonstrates that elevated FGF19 expression or hyperactivation of FGF19/FGFR4 (show FGFR4 Proteins) signaling in hepatocellular carcinoma cells is one of the main mechanisms of sorafenib resistance.

5. This is the first study to elucidate FGF19/FGFR4 (show FGFR4 Proteins) signaling in favor of hepatocellular carcinoma cells developing from fatty liver

6. High expression of FGF19 is associated with hepatocellular carcinoma.

7. Findings show that FGF19 provides a cytoprotective role against ER stress by activating a FGFR4 (show FGFR4 Proteins)-GSK3beta-Nrf2 (show GABPA Proteins) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (show FAM126A Proteins)) management.

8. Fibroblast growth factor 19 levels in human portal blood are higher than in arterial blood. Fibroblast growth factor 19 is released by the portal-drained viscera under fasted steady state conditions.

9. serum FGF19 and FGF21 and hepatic Klotho expression are inversely associated with hepatic damage in children with NAFLD

10. Administering FGF19, or suitable mimetic, as a pharmacological intervention to increase circulating levels of FGF19 and suppress BA synthesis by inhibiting CYP7A1 (show CYP7A1 Proteins) gene expression is likely to provide therapeutic benefits for many PBC (show DLAT Proteins) patients

Zebrafish Fibroblast Growth Factor 19 (FGF19) interaction partners

1. Fgf19 signaling is critical for embryonic forebrain development through its interaction with hedgehog (show SHH Proteins).

2. This study reveals an important role for FOXC1 (show FOXC1 Proteins) in the direct regulation of the FGF19-FGFR4 (show FGFR4 Proteins)-MAPK (show MAPK1 Proteins) pathway to promote both the development and maintenance of anterior segment structures within the eye.

3. Fgf19 is required for zebrafish lens and retina development.