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our study demonstrated that FGFR4 (show FGFR4 Proteins) rs2011077 and rs1966265 are associated with the progression of cervical normal tissues to precancerous lesions in Taiwanese women. Moreover, rs351855 (Gly388Arg) is the only FGFR4 (show FGFR4 Proteins) genetic polymorphism that is associated with patient survival.
Thus, we conclude that the oncoprotein HBXIP (show HBXIP Proteins) up-regulates FGF4 through activating transcriptional factor Sp1 (show PSG1 Proteins) to promote the migration of breast cancer cells. Therapeutically, HBXIP (show HBXIP Proteins) may serve as a novel target in breast cancer.
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Data show that the interaction between Artd1 (show PARP1 Proteins) and Sox2 (show SOX2 Proteins) is crucial for the first steps of the reprogramming process and that early expression of Fgf4 is an essential component for the successful generation of iPSCs.
A de novo 290 kb interstitial duplication of chromosome 11q13.3 including the FGF3 (show FGF3 Proteins) and FGF4 genes.
Myoblasts which overexpress FGF-4 exhibit significant changes in cell cycle and pro-angiogenic potential with only slight differences in the expression of the myogenic genes.
In vivo stimulation of BT-474 cell growth by progesterone is associated with up-regulation of FGF4 which may promote tumor growth and maintenance.
knockdown of FGFR4 (show FGFR4 Proteins) expression led to decreased proliferation and an increased rate of apoptosis in the MKN45 and SGC7901 GC cell lines
activation of human HST-1 gene in transgenic mice induces spermatogenesis and prevents adriamycin-induced testicular toxicity
possible role of fibroblast growth factors in expression of genes of the plasminogen (show PLG Proteins) activator system in breast fibroblasts
The correlation in expression of FGF4 with specific stages of tooth morphogenesis support its regulatory function.
We demonstrate with genetic evidence that the Wnt5a (show WNT5A Proteins) gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP (show BMP1 Proteins)) in the limb mesenchyme, and that Wnt5a (show WNT5A Proteins) also plays a permissive role to allow Fgf4 and Fgf8 (show FGF8 Proteins) signaling to orient PCP (show BMP1 Proteins).
Klf5 (show KLF5 Proteins) suppresses Fgf4-Fgfr (show FGFR2 Proteins)-ERK (show EPHB2 Proteins) signalling, thus preventing precocious activation of the primitive endoderm specification programme
the paternal genome facilitates the proliferation of trophoblast cells without FGF4 signaling
There was intense Fgf4 expression observed in the PEK (show EIF2AK3 Proteins) of the cap-stage tooth germ at E14. At E15, Fgf4 became sparse in the epithelium except for the PEK (show EIF2AK3 Proteins). Fgf4 was exclusively expressed in the apical end of the labial (show LAT2 Proteins) epithelium during E16 (show SLC7A5 Proteins)-18
With efficient chimera-forming capability using a medium containing fibroblast growth factor (FGF)-4.
Taken together, our results demonstrated that mating behaviours influenced embryonic development in vitro by decreasing FGF4 expression.
the amount of FGF4 is limited and regulates PE/EPI (show TFPI Proteins) proportions in the mouse embryo.
The role of Fgf4 in response to apoptosis and genotoxic stress is discussed.
FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse
Present study provides a simple method for the production of a bioactive bovine FGF4 derivative in E.coli utilizing its structural gene.
this is the first determination of the complete nucleotide sequence of the structural gene encoding bovine FGF4 in identified breeds
Fgf4 exhibited significant hypermethylation in sperm compared with that in oocytes
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
, fibroblast growth factor 4 splice isoform
, heparin secretory transforming protein 1
, heparin secretory-transforming protein 1
, heparin-binding growth factor 4
, human stomach cancer, transforming factor from FGF-related oncogene
, kaposi sarcoma oncogene
, oncogene HST
, transforming protein KS3
, K-fibroblast growth factor
, heparin-binding growth factor 1
, fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)
, heparin secretory-transforming protein