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anti-Human FGF5 Antibodies:
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Human Polyclonal FGF5 Primary Antibody for ELISA, WB - ABIN4311609
Liu, Li, Qi, Lu, Gan, Loos, Lin: Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans. in Journal of hypertension 2010
Knockdown of fgf5 prolongs the phase of neuroblast specification and also accelerates the rate of neuronal differentiation
Study indicated that MTHFR rs1801133, FGF5 rs16998073 and CSK rs1378942 were associated with increased the risk of obesity in the Chinese children.
FGF5 is an independent protective factor for breast cancer patients.
The results suggest that FGF2/rs1048201, FGF5/rs3733336 and FGF9/rs546782 are associated with the risk of non-syndromic orofacial cleft and that these miRNA-FGF interactions may affect non-syndromic orofacial cleft development.
These results provide new insight into the functions of miR-9-3p and HBGF-5 in HCC and identify miR-9-3p as a potential therapeutic target for HCC
FGF5 facilitates cell proliferation through ERK1/2 activation, and it influences the osteogenic differentiation of tonsil-derived mesenchymal stem cells.
These findings collectively demonstrate a tumor suppressor role of miR-188-5p in HCC progression via targeting FGF5
High BMI increases the effect of the blood pressure-increasing allele at rs1458038 near FGF5 in a Chinese population.
In Chinese children, no association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
FGF5 is a crucial regulator of hair growth in humans.
Meta-analysis indicated significant associations of both CYP17A1 rs11191548 and FGF5 rs16998073 polymorphisms with hypertension susceptibility in East Asians.
Variants in or near FGF5, CYP17A1 and MTHFR contributed to variation in BP and hypertension risk. Effect sizes of these three loci tended to be larger in Chinese than in white Europeans
variation in FGF5 and ZNF652 gene upstream regions with altered susceptibility to hypertension in Han Chinese
The role of the proteasome is confirmed when a spliced FGF-5 peptide is produced in vitro after incubation of proteasomes with a 49-amino-acid precursor peptide in a transpeptidation splicing model.
possible role of fibroblast growth factors in expression of genes of the plasminogen activator system in breast fibroblasts
FGF5 contributes to the malignant progression of human astrocytic brain tumours by both autocrine and paracrine effects.
Recruited CD11b+ CD68+ Kupffer cells/Mphis may play an essential role in steatohepatitis and fibrosis in FGF5 null mice fed with a HFD. Recruitment and activation of bone marrow derived Mphis is the key factor to develop steatohepatitis from simple steatosis.
It participates in the progression of hepatic fibrosis.
Interaction of mutant genes Fgf5(go-Y), we, and wal changes the duration of hair growth cycles in mice
A deletion of a 9.3-kb region in the Fgf5 gene showed insertion of a 498-bp early transposon element long terminal repeat. Results show that long hair mutation of moja/moja mice is caused by Fgf5 disruption mediated by retrotransposon insertion.
Fluctuations of BMP2 signaling pathway during hair cycles in skin with mutant genes we, wal and Fgf5(go).
parathyroid hormone-related protein and fibroblast growth factor-5 regulate the anagen to catagen transition by independent pathways
the Fgf5(go) gene is a powerful modifier of mutant genes determining the process of alopecia.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.
fibroblast growth factor 5
, heparin-binding growth factor 5
, fibroblast growth factor FGF-5