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Human FGF8 Protein expressed in Escherichia coli (E. coli) - ABIN935347
Borello, Cobos, Long, McWhirter, Murre, Rubenstein: FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. in Neural development 2008
We demonstrate with genetic evidence that the Wnt5a (show WNT5A Proteins) gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP (show BMP1 Proteins)) in the limb mesenchyme, and that Wnt5a (show WNT5A Proteins) also plays a permissive role to allow Fgf4 (show FGF4 Proteins) and Fgf8 signaling to orient PCP (show BMP1 Proteins).
THe Fgf8-Cre reporter expression in isthmic structures in mice include 'signature' isthmic structures in mice include the trochlear nucleus, the dorsal raphe nucleus, the microcellular tegmental nuclei, the pedunculotegmental nucleus, the vermis of the cerebellum, rostral parts of the parabrachial complex and locus coeruleus, and the caudal parts of the substantia nigra and VTA.
Results indicate that perinatal fibroblast growth factor 8 (FGF8) signaling is important for the timing of the onset of anterior-dorsal glial fibrillary acidic protein (show GFAP Proteins) expression in midline glial cells suggesting that FGF8 function regulates midline GFAP (show GFAP Proteins)-IR glial cell development, which when disrupted by Fgf8 deficiency prevents the formation of the corpus callosum.
The FBLN1 (show FBLN1 Proteins)/FGF8 interaction may also be involved in the survival of neural crest cell population during development.
These results indicate that the modulatory effects of SHH (show SHH Proteins) on BALB/c mouse metanephric explant cultures may involve the regulation of Fgf8 expression but not Fgf10 (show FGF10 Proteins) expression, which provides evidence for the functional role of Fgf proteins in renal morphogenesis.
FGF-8 was revealed to suppress BMP-induced osteoblast differentiation through the ERK (show EPHB2 Proteins) pathway and the effects were enhanced by TNF-alpha (show TNF Proteins).
Fgf8 expression is required for the continued postnatal development/maturation of the Vasopressin (show AVP Proteins) and CRH (show CRH Proteins) neurons in the Paraventricular nucleus.
Deregulated FGF8 and Otx2 (show OTX2 Proteins)/Gbx2 (show GBX2 Proteins) gene expression underlies cerebellar vermis hypoplasia in mouse model of CHARGE syndrome.
Cre fate mapping in Fgf8 mutant embryos revealed novel functions of this gene in rostral patterning center progenitor development. Disruption resulted in aberrant progenitor number and distribution in the rostral telencephalon.
Tfap2a (show TFAP2A Proteins)-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage
we also found that FGF8 increased the expression of YAP1 (show YAP1 Proteins) and knockdown of YAP1 (show YAP1 Proteins) eliminated the upregulation of EGFR (show EGFR Proteins) and the resistance to EGFR (show EGFR Proteins) inhibition induced by FGF8. Our study provides evidence that FGF8 plays an important role in the resistance to EGFR (show EGFR Proteins) inhibition of human hepatocellular carcinoma cells
Genetic testing identified a de novo, heterozygous mutation in fibroblast growth factor receptor 1 (FGFR1 (show FGFR1 Proteins) p.L630P). L630 resides on the ATP binding cleft of the FGFR1 (show FGFR1 Proteins) tyrosine kinase (show TXK Proteins) domain, and L630P is predicted to cause a complete loss of receptor function. Cell-based assays confirmed that L630P abolishes FGF8 signaling activity
Bonferroni adjusted p-value: 0.04). No statistically significant associations were identified in the other ethnic groups. In conclusion, variant/s in FGF2 and FGF8 may predispose diabetics with CKD to LEA.
in one holoprosencephaly (HPE) family, a deleterious FGFR1 (show FGFR1 Proteins) allele was transmitted from one parent and a loss-of-function allele in FGF8 from the other parent to both affected daughters. This family is one of the clearest examples to date of gene:gene synergistic interactions causing HPE in humans.
Fgf8 activates Ras-ERK (show EPHB2 Proteins) pathway to specify hindbrain. Downstream of ERK (show EPHB2 Proteins), Pea3 (show ETV4 Proteins) specifies isthmus (rhombomere 0, r0), and Irx2 (show IRX2 Proteins) may specify r1, where the cerebellum is formed.
Regulation of neurogenesis by Fgf8a requires Cdc42 (show CDC42 Proteins) signaling and a novel Cdc42 effector (show FNBP1L Proteins) protein
Our results link FGF8, c-Abl (show ABL1 Proteins) and p300 (show EP300 Proteins) in a regulatory pathway that controls DeltaNp63alpha protein stability and transcriptional activity.
Data indicate that overexpression of fibroblast growth factor 8 (FGF8) correlates with lymph node metastasis and poor prognosis in colorectal cancer (CRC (show CALR Proteins)).
FGF8 mutations (p.Gly29_Arg34dup and p.Pro26Leu) contribute to the formation of the VATER/VACTERL association.
FGF8 and FGF18 (show FGF18 Proteins) signal through divergent pathways in ovarian granulosa cells, despite reportedly similar receptor activation patterns.
These results suggest that polymorphisms discovered in DECR1 (show DECR1 Proteins), CBFA2T1 (show RUNX1T1 Proteins), and FGF8 may play a role in the lipid metabolism pathway affecting carcass quality traits in beef cattle.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.
, androgen-induced growth factor
, heparin-binding growth factor 8
, fibroblast growth factor 8 (androgen-induced)
, fibroblast growth factor 8
, fibroblast growth factor-8
, fibroblast growth factor 8 (androgen-induced) isoform 1
, fibroblast growth factor 8 (androgen-induced) isoform 2
, fibroblast growth factor 8 (androgen-induced) isoform 3