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Human FGFR1 Protein expressed in Insect Cells - ABIN1589526
Lohr, Mock, Beckhove, Herold-Mende: Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature. in Anticancer research 2015
Show all 3 Pubmed References
Human FGFR1 Protein expressed in Human Cells - ABIN2003140
Soker, Takashima, Miao, Neufeld, Klagsbrun: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. in Cell 1998
Show all 5 Pubmed References
These results suggest that bFGF (show FGF2 Proteins) activation of neuronal FGFR1 generates filopodial processes in neurons that promote nerve-muscle interaction and facilitate NMJ establishment.
in FGFR1 signalling JNK1 (show MAPK8 Proteins) phosphorylation depends on ERK2 (show MAPK1 Proteins)
Mactosylceramide, an early product in GSL (show CTSA Proteins) biosynthesis, prevents inappropriate activation of insulin (show INS Proteins) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
identify two transcriptional regulators that function downstream of Heartless signaling in lymph gland progenitors, the ETS protein, Pointed, and the Friend-of-GATA protein, U-shaped, which are required for this Heartless-induced differentiation response
We show that salivary gland posterior migration requires the activities of genes that position the visceral mesoderm precursors, such as heartless, thickveins, and tinman (show MSH2 Proteins), but does not require a differentiated visceral mesoderm.
the signal provided by the CAMs acts via the Heartless fibroblast growth factor receptor (FGFR) as outgrowth is reduced to basal levels in the presence of an FGFR (show FGFR2 Proteins) inhibitor or if Heartless function is missing from the neurons.
Study finds infrequent BRAF (show BRAF Proteins) alterations but enriched FGFR (show FGFR2 Proteins) alterations in adults as compared with that reported in pediatric pilocytic astrocytomas. In addition, coexistent BRAF (show BRAF Proteins) and FGFR (show FGFR2 Proteins) alterations and a significant association of FGFR (show FGFR2 Proteins) alterations with age and tumor location were noted.
SNP rs17182023 was correlated to reduced breast cancer risk, and was associated with FGFR1 protein expression. High FGFR1 protein expression was an independent risk factor of breast cancer, and resulted in poor prognosis.
Besides RET (show RET Proteins) and HRAS (show HRAS Proteins), FGFR1 is only the third protooncogene found to be recurrently mutated in pheochromocytomas.
For the treatment of patients with breast cancer and FGFR1 amplifications.
presentation of the atomic structure of a 1:1:1 ternary complex that consists of the shed extracellular domain of alpha-klotho (show KL Proteins), the FGFR1c ligand-binding domain, and FGF23 (show FGF23 Proteins); in this complex, alpha-klotho (show KL Proteins) simultaneously tethers FGFR1c by its D3 domain and FGF23 (show FGF23 Proteins) by its C-terminal tail, thus implementing FGF23 (show FGF23 Proteins)-FGFR1c proximity and conferring stability
Study identified FGFR1, a promoter of glycolysis-related enzyme, as the target of miR (show MLXIP Proteins)-361 that promoted glycolysis and repressed oxidative phosphorylation in breast cancer cells. FGFR1 mediated the anti-glycolytic function of miR (show MLXIP Proteins)-361 by regulating the activity of PDHK1 and LDHA (show LDHA Proteins).
FGFR1 and/or FGF3 (show FGF3 Proteins) gene amplification correlated with a lower pathologic complete response in patients with HER2 (show ERBB2 Proteins)(+) early breast cancer treated with neoadjuvant anti-HER2 (show ERBB2 Proteins) therapy.
Data demonstrated that FOXC1 (show FOXC1 Proteins) binds to an Fgfr1 upstream regulatory region and that FOXC1 (show FOXC1 Proteins) activates an Fgfr1 promoter element. Furthermore, elevated expression of Foxc1 (show FOXC1 Proteins) led to increased Fgfr1-IIIc transcript promoting invasion after TGFbeta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins).
These results suggest that FGFR1 gene amplification is a frequent alteration in squamous cell carcinoma of the lung and appears not to be a negative but rather a favorable prognostic marker for women and particularly for patients with advanced disease
These data suggest the ERalpha (show ESR1 Proteins) pathway remains active in estrogen-deprived ER(+)/FGFR1-amplified breast cancers. Therefore, these tumors are endocrine resistant and should be candidates for treatment with combinations of ER and FGFR (show FGFR2 Proteins) antagonists.
Oligodendroglial FGFR1 deficient mice (-/-) showed a significantly ameliorated disease course in MOG35-55 -induced experimental autoimmune encephalomyelitis. Less myelin and axonal loss, and reduced lymphocyte and macrophage/microglia infiltration were found in Fgfr1(-/-) mice. Reduction in disease severity in Fgfr1(ind-/-) mice was accompanied by ERK (show EPHB2 Proteins)/AKT (show AKT1 Proteins) phosphorylation, and increased expression of BDNF (show BDNF Proteins) and TrkB (show NTRK2 Proteins).
Suboptimal FGFR (show FGFR2 Proteins) activation by a weak FGF1 (show FGF1 Proteins)-FGFR (show FGFR2 Proteins) dimer is sufficient to evoke a metabolic response, whereas full FGFR (show FGFR2 Proteins) activation by stable and sustained dimerization is required to elicit a mitogenic response.
the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta (show TGFB1 Proteins)/smad (show SMAD1 Proteins) signaling and EndMT associated with MAP4K4 (show MAP4K4 Proteins) phosphorylation (P-MAP4K4 (show MAP4K4 Proteins)) in endothelial cells.
FGFR1 is a driver oncogene (show RAB1A Proteins) in de novo, FGFR1-overexpressing acute myeloid leukemia (show BCL11A Proteins)
Visceral adipose tissue-derived factors stimulate cell transformation through FGFR-1.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
CDC42 (show CDC42 Proteins) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (show MAPK1 Proteins) cascades participate in osteogenesis, but only the ERK (show EPHB2 Proteins) signaling pathway responds to FGFR1.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (show FGFR2 Proteins) 2, in the oligodendr
data suggest that FGF2 (show FGF2 Proteins) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Proteins) expression, an effect that is likely receptor mediated, albeit not by FGFR1, FGFR2 (show FGFR2 Proteins), and FGFR3 (show FGFR3 Proteins).
activation of FGFR1 and FGFR2 (show FGFR2 Proteins) by uterine- and endometrial-derived FGF2 (show FGF2 Proteins) stimulates PI3K/AKT (show AKT1 Proteins) and mitogen-activated protein kinase (show MAPK1 Proteins) pathways for development of the porcine uterus and improvement of litter size
Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
mRNA and protein expression of FGFR-1, FGFR-2 (show FGFR2 Proteins) in the porcine umbilical cord during pregnancy.
Here we demonstrate that of the nine FGFR1 mutations recently detected in our screen of over 200 HPE probands by next generation sequencing, only five distinct mutations in the kinase domain behave as dominant-negative mutations in zebrafish over-expression assays
we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
Data indicate that fgf20a, fgf24, FGF receptor (show FGFR2 Proteins) fgfr1 are expressed in normal and regenerating barbel tissue.
Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish.
fgfr (show FGFR2 Proteins) expression is directly or indirectly regulated by FGF signaling during epiboly and at the end of somitogenesis.
we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1).
knock-down of Fgfr1, but not muscle segment homeobox B, affected the blastemal expression of msxc, suggesting this technique can be used to determine epistasis in genetic pathways affecting regeneration
Bmp and Fgf signaling are essential for liver specification in zebrafish.
The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Proteins) and its receptors, fgfr1 and fgfr4 (show FGFR4 Proteins), using combined spectroscopy methods are reported.
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
fibroblast growth factor receptor
, fibroblast growth factor receptor-1
, basic fibroblast growth factor receptor 1
, FGF receptor
, fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, ibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
, basic fibroblast growth factor receptor 1-like
, FGFR1/PLAG1 fusion
, FMS-like tyrosine kinase 2
, fms-related tyrosine kinase 2
, heparin-binding growth factor receptor
, hydroxyaryl-protein kinase
, proto-oncogene c-Fgr
, FGF receptor-1
, cek1 protein
, tyrosine kinase receptor CEK1
, basic fibroblast growth factor receptor 1-A
, fibroblast growth factor receptor 1-A