Browse our FGFR2 Proteins (FGFR2)

Full name:: Fibroblast Growth Factor Receptor 2 Proteins (FGFR2)

On www.antibodies-online.com are 45 Fibroblast Growth Factor Receptor 2 (FGFR2) Proteins from 14 different suppliers available. Additionally we are shipping FGFR2 Antibodies (343) and FGFR2 Kits (29) and many more products for this protein. A total of 448 FGFR2 products are currently listed.

Synonyms:: AU043015, AW556123, BBDS, Bek, BFR-1, CD332, CEK3, CFD1, DKFZp469H1521, ECT1, fc56c05, FGF-R, FGFR, Fgfr-2, Fgfr-7, FGFR2, FGFR2IIIb, Fgfr7, fgfr72IIIb, JWS, K-SAM, KGFR, KGFRTr, svs, TK14, TK25, wu:fc56c05, xfgfr2

list all proteins	Gene Name	GeneID	UniProt
	FGFR2	2263	P21802
	FGFR2	14183	P21803
Rat FGFR2	FGFR2	25022
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FGFR2 Proteins (FGFR2) by Origin

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Human Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

provide a comprehensive update on FGFR2-related syndromic craniosynostosis
The mutations were not present in any of the unaffected family members or unrelated control subjects. These findings expand the mutation spectrum of FGFR2, and are valuable for genetic counseling in addition to prenatal diagnosis in patients with Crouzon syndrome.
Fibroblast growth factor receptor 2 (FGFR2) splice site variants were identified in eight patients with Crouzon or Pfeiffer syndrome.
Data suggest that the SOX9 transcription factor (SOX9 (show SOX9 Proteins))-fibroblast growth factor receptor 2 (FGFR2b) feed-forward loop has a lineage dependency role in pancreatic ductal adenocarcinoma (PDAC).
Studies indicate that switching from fibroblast growth factor receptor 2 (FDFR-2) IIIb to IIIc variants correlates with the aggressiveness of the cancers via epithelial-mesenchymal transition [Review].
These results unveil the complexity of ER regulation by FGFR2-mediated signaling likely to be associated with BCa (show BLNK Proteins) resistance to endocrine therapy.
Study report that 5-10% of epidermal nevi harbor embryonic postzygotic FGFR2 activating mutations.
this study identified an FGFR2 in two Chinese patients with syndromic craniosynostosis. The finding expands the reported mutation spectrum of FGFR2, and is of great value for genetic counseling and prenatal diagnosis in families with syndromic craniosynostosis.
Through a stratification analysis, 5q11.2/MAP3K1 (show MAP3K1 Proteins) (rs16886034, rs16886364, rs16886397, rs1017226, rs16886448) and 7q32.3/LINC-PINT (rs4593472) were associated with Luminal A, and 10q26.1/FGFR2 (rs35054928) was associated with Luminal B.
SNORD126 activates the PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) pathway by upregulation of FGFR2.

Mouse (Murine) Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

gain-of-function mutation in FGFR2 exerts a Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-dependent anabolic effect on trabecular bone by promoting bone formation.
small interfering RNA knockdown of FGFR2 suppressed PI3K/Akt (show AKT1 Proteins) pathway activation by FGF10 (show FGF10 Proteins) and abolished its anti-apoptotic and neurite repair effects in vitro.
Testis determination involves FGFR2c-mediated repression of both the WNT4 (show WNT4 Proteins)- and FOXL2 (show FOXL2 Proteins)-driven ovarian-determining pathways.
the localization of FGF9 and its receptors at different embryonic and postnatal stages in mice testes, was examined.
FGFR2 signalling correlates with maintenance of expression of a key transcription factor for basal cell self-renewal and differentiation: SOX2 (show SOX2 Proteins).
Fgfr2 is seen within submucosal glandular epithelial cells. The medial nasal glands were missing in Fgfr2b mutants.
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor 2, in the oligodendr
data suggest that FGF2 (show FGF2 Proteins) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Proteins) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (show FGFR1 Proteins), FGFR2, and FGFR3 (show FGFR3 Proteins).
Results show that Fgfr2 regulates both the formation and resolution of tetrads and rosettes in the mouse embryo, possibly in part by spatially restricting atypical protein kinase C, a negative regulator of non-muscle myosin IIB.
FGFR2c signaling regulates branching morphogenesis through the activation of FGFR2b signaling via increased FGF10 (show FGF10 Proteins) autocrine. These results provide new insight into the mechanisms by which crosstalk between FGFR2b and FGFR2c results in efficient branching morphogenesis.

Pig (Porcine) Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

mRNA and protein expression of FGFR-1 (show FGFR1 Proteins), FGFR-2 in the porcine umbilical cord during pregnancy.
EGFR (show EGFR Proteins), VEGFR (show KDR Proteins) and FGFR are expressed in porcine oviduct and endometrium during the time of implantation [review]
analysis of regulation of endometrial fibroblast growth factor 7 (FGF-7 (show FGF7 Proteins)) and its receptor FGFR2IIIb

Cow (Bovine) Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

FGFR2 signaling appears to be associated with the regulation of inner cell mass development and proliferation during blastocyst formation in cattle.
activation of FGFR1 (show FGFR1 Proteins) and FGFR2 by uterine- and endometrial-derived FGF2 (show FGF2 Proteins) stimulates PI3K/AKT (show AKT1 Proteins) and mitogen-activated protein kinase (show MAPK1 Proteins) pathways for development of the porcine uterus and improvement of litter size
it is highly likely that the missense mutation in the FGFR2 gene caused the bovine facial dysplasia syndrome phenotype in a dominant mode of inheritance.
FGF10 (show FGF10 Proteins) and its receptor FGFR2b are more expressed in subordinate follicles; FGF10 (show FGF10 Proteins) acts as an important regulator of follicular growth in cattle.
Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
These data support a role for FGF10 (show FGF10 Proteins) and fibroblast growth factor receptor 2B in signaling to granulosa cells from theca cells and/or the oocyte.(fibroblast growth factor receptor 2B)
FGF10 (show FGF10 Proteins) mRNA expression did not change during functional luteolysis, whereas FGFR2B mRNA abundance decreased significantly at 2, 4, and 12 hr after PGF2alpha, and returned to pretreatment levels for the period 24-64 hr post-PGF2alpha

Zebrafish Fibroblast Growth Factor Receptor 2 (FGFR2) interaction partners

we show that minimal amounts of Fgfr1a or Fgfr2 are required to initiate a regulatory cascade in pharyngeal endoderm reducing expression of fsta, thereby allowing correct BMP signaling to the maturing chondrocytes of the head cartilage.
the roles of Fgfr2 signaling in zebrafish left-right asymmetry

FGFR2 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Alternative names and synonyms associated with FGFR2

fibroblast growth factor receptor 2 (FGFR2)
fibroblast growth factor receptor 2 (LOC100084641)
fibroblast growth factor receptor 2 (fgfr2)
fibroblast growth factor receptor 2 (Fgfr2)
fibroblast growth factor receptor 2 L homeolog (fgfr2.L)

AU043015 protein
AW556123 protein
BBDS protein
Bek protein
BFR-1 protein
CD332 protein
CEK3 protein
CFD1 protein
DKFZp469H1521 protein
ECT1 protein
fc56c05 protein
FGF-R protein
FGFR protein
Fgfr-2 protein
Fgfr-7 protein
FGFR2 protein
FGFR2IIIb protein
Fgfr7 protein
fgfr72IIIb protein
JWS protein
K-SAM protein
KGFR protein
KGFRTr protein
svs protein
TK14 protein
TK25 protein
wu:fc56c05 protein
xfgfr2 protein

Protein level used designations for FGFR2

fibroblast growth factor receptor 2 , bacteria-expressed kinase , keratinocyte growth factor receptor , fibroblast growth factor receptor 2 IIIb , fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) , BEK fibroblast growth factor receptor , FGF receptor , FGFR-2 , hydroxyaryl-protein kinase , protein tyrosine kinase, receptor like 14 , soluble FGFR4 variant 4 , FGF-7 receptor 2IIIb , fgf receptor , chicken tyrosine kinase (cek3) , receptor tyrosine kinase , tyrosine kinase receptor CEK3 , fibroblast growth factor receptor-2

GENE ID	SPECIES
443548	Ovis aries
466220	Pan troglodytes
715949	Macaca mulatta
100033956	Equus caballus
100084641	Ornithorhynchus anatinus
100124910	Xenopus (Silurana) tropicalis
100171540	Pongo abelii
100468267	Ailuropoda melanoleuca
2263	Homo sapiens
14183	Mus musculus
25022	Rattus norvegicus
415125	Canis lupus familiaris
396762	Sus scrofa
404193	Bos taurus
396259	Gallus gallus
399325	Xenopus laevis
100009417	Oryctolagus cuniculus
100379152	Cavia porcellus
352940	Danio rerio

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